Distribution and anti-nociceptive function of endomorphin-1 in the rat cranial sensory ganglia [0.03%]
大鼠颅神经感觉神经节中内脑啡肽-1的分布和镇痛功能
Shun Sato,Tadasu Sato,Takehiro Yajima et al.
Shun Sato et al.
Distribution of endomorphin-1 (EM-1) was immunohistochemically investigated in the rat cranial sensory ganglia. Small to medium-sized neurons in the trigeminal (TG), petrosal (PG), and jugular ganglia (JG) expressed EM-1-immunoreactivity. H...
Tenascin-X is increased with decreased expression of miR-378a-5p and miR-486-5p in mice fed a methionine-choline-deficient diet that induces hepatic fibrosis [0.03%]
蛋氨酸胆碱缺乏饮食诱导肝纤维化的机制与小鼠Tenascin-X的上调及miR-378a-5p和miR-486-5p的下调有关
Ken-Ichi Matsumoto,Takuma Higuchi,Mirei Umeki et al.
Ken-Ichi Matsumoto et al.
We previously reported that tenascin-X (Tnxb) aggravates hepatic fibrosis in mice fed a high-fat and high-cholesterol diet with high levels of phosphorus and calcium (HFCD). In this study, we investigated Tnxb expression in livers with fibr...
Indoxyl sulfate contributes to colorectal cancer cell proliferation and increased EGFR expression by activating AhR and Akt [0.03%]
吲哚硫酸盐通过激活AhR和Akt促进结直肠癌细胞增殖和EGFR表达上调
Yu Ichisaka,Shozo Yano,Kohji Nishimura et al.
Yu Ichisaka et al.
Although patients with chronic kidney disease (CKD) have a higher risk of colorectal cancer (CRC) aggravation, the connection between these two diseases is not well understood. Recent studies have shown that both CKD and CRC aggravation are...
Involvement of interaction of Cav3.2 and nociceptive TRPA1 in pathological pain transmission [0.03%]
Cav3.2与痛觉感受TRPA1的相互作用在病理性疼痛传递中的作用
Minami Nakagawa,Kenji Takahashi,Yuki Nishizawa et al.
Minami Nakagawa et al.
T-type Ca2+ channels and TRPA1 expressed in sensory neurons are involved in pain. We previously demonstrated a functional interaction of these channels under physiological conditions. Here we investigated the possible involvement of these c...
Fish oil consumption prevents hepatic lipid accumulation induced by high-cholesterol feeding in obese KK mice [0.03%]
鱼油消耗预防高胆固醇饲料诱导的肥胖KK小鼠肝脏脂质积聚
Satoshi Hirako,HyounJu Kim,Yuzuru Iizuka et al.
Satoshi Hirako et al.
Fish oil (FO) is rich in the n-3 polyunsaturated fatty acids. It has been demonstrated that FO intake possesses lipid-lowering properties. Conversely, a high-cholesterol (CH) diet promotes lipid accumulation in the liver and induces fatty l...
Cell cycle dependence of cell survival following exposure to X-rays in synchronous HeLa cells expressing fluorescent ubiquitination-based cell cycle indicators [0.03%]
同步HeLa细胞中荧光泛素化细胞周期指示剂表达后的X射线照射依赖细胞周期的生存率
Ryosuke Seino,Hiroto Uno,Kevin M Prise et al.
Ryosuke Seino et al.
The cell cycle dependence of radiosensitivity has yet to be fully determined, as it is technically difficult to achieve a high degree of cell cycle synchronization in cultured cell systems and accurately detect the cell cycle phase of indiv...
Rutin promotes M2 phenotype microglia polarization by suppressing the JAK/STAT3 signaling to protect against retinal ischemia-reperfusion injury [0.03%]
rutin通过抑制JAK / STAT3信号传导促进M2表型小胶质细胞极化以保护免受视网膜缺血再灌注损伤
An-Le Su,Shuai Zhao,Hong-Na Zhu et al.
An-Le Su et al.
We aimed to investigate the neuroprotective effect of rutin on retinal ganglion cells (RGCs) under ischemia-reperfusion (I/R) conditions and the underlying mechanisms involving microglia polarization and JAK/STAT3 signaling. RGCs isolated f...
Epigenetic modification of histone acetylation in the sensorimotor cortex after intracerebral hemorrhage [0.03%]
脑出血后感觉运动皮层组蛋白乙酰化修饰的表观遗传变化
Taichi Nishio,Takahiro Inoue,Yasuyuki Takamatsu et al.
Taichi Nishio et al.
Epigenetic regulation is involved in post-stroke neuroplasticity. We investigated the effects of intracerebral hemorrhage (ICH) on histone acetylation and gene expression related to neuronal plasticity in the bilateral sensorimotor cortices...
Fractalkine's dual role in inflammation and hard tissue formation in cultured human dental pulp cells [0.03%]
人类牙髓细胞培养中 fractalkine 在炎症和硬组织形成中的双重作用
Natsuko Gomyo-Furuya,Naoto Kamio,Takahiro Watanabe et al.
Natsuko Gomyo-Furuya et al.
This study aimed to explore the potential roles of fractalkine/CX3CR1, primarily expressed in vascular endothelial cells and has recently been identified in dental pulp cells at sites of pulp tissue inflammation, not only in inflammation bu...
Hypoxia-induced endothelial cell-derived exosome stimulates vascular smooth muscle cell proliferation and migration [0.03%]
缺氧诱导的内皮细胞源性外泌体刺激血管平滑肌细胞增殖和迁移
Qinggen Xiong,Fei Lu,Xiaoming Xie et al.
Qinggen Xiong et al.
This study mainly used human VSMCs and ECs cultured in vitro to investigate whether exosomes (Exos) are involved in the communication between ECs and VSMCs under hypoxia, and to explore the role and mechanism of ECs-derived exosomes in the ...