Identification of membrane proteins targeted by small-molecule compounds using nanomagnetic beads [0.03%]
利用纳米磁珠鉴定小分子化合物的作用膜蛋白目标
Yasufumi Kikuchi,Takayuki Ando,Tadashi Ashizawa et al.
Yasufumi Kikuchi et al.
In drug discovery research, it is important to identify target proteins of bioactive small-molecule compounds and analyse their functions. In this study, we examined whether target membrane proteins could be captured by compounds that bind ...
Inhibition of skeletal muscle differentiation by calciprotein particles in human primary myoblasts [0.03%]
钙蛋白颗粒通过作用于人原代肌管抑制骨骼肌分化
Shohei Kohno,Eisuke Uno,Kazuto Goishi et al.
Shohei Kohno et al.
Sarcopenia is a common complication of chronic kidney disease (CKD) and has a detrimental effect on prognosis. Previous studies have explored the role of secondary calciprotein particles (CPP2) in determining the progression of complication...
Effects of inactivity and exercise intervention on brain-derived neurotrophic factor in mice: Comparison of kinetics in serum, skeletal muscle, and brain [0.03%]
运动干预对小鼠脑源性神经营养因子影响的实验研究及血流milan、骨骼肌和大脑中动力学比较研究
Azusa Miki,Masahiro Aihara,Hikaru Kawaguchi et al.
Azusa Miki et al.
Exercise training increases brain-derived neurotrophic factor (BDNF) expression and improves cognitive function. However, the dynamics of BDNF during inactivity and the effects of exercise intervention on BDNF levels have rarely been examin...
Comparative Study
Biomedical research (Tokyo, Japan). 2024;45(4):163-172. DOI:10.2220/biomedres.45.163 2024
Effects of linalool on respiratory neuron activity in the brainstem-spinal cord preparation from newborn rats [0.03%]
香茅醇对新生大鼠脑干脊髓准备呼吸神经元活性的影响
Yuka Shibuya,Kayo Tsuzawa,Hiroshi Onimaru et al.
Yuka Shibuya et al.
Linalool and linalyl acetate are major components of lavender essential oil. These substances possess many biological activities, such as anti-inflammatory activity, analgesic and anxiolytic effects, and anticonvulsant properties, and they ...
Copper-induced renal toxicity controlled by period1 through modulation of Atox1 in mice [0.03%]
Period1通过调节Atox1控制铜诱导的肾毒性
Sarah Tominaga,Hiroki Yoshioka,Satoshi Yokota et al.
Sarah Tominaga et al.
Copper (Cu) is known to induce oxidative stress and apoptosis in the liver, kidney, and brain. We previously demonstrated the molecular mechanism underlying the Cu-induced hepatic diurnal variation. However, the cellular molecule(s) involve...
The characteristics and prevalence of patent foramen ovale in Japanese people: a study using material from forensic autopsies [0.03%]
日本人的房间隔缺损的特点和流行病学特征——一项基于法医尸体解剖材料的研究
Yoshiko Miyawaki,Masahito Hitosugi,Arisa Takeda et al.
Yoshiko Miyawaki et al.
Racial and ethnic differences in the prevalence of patent foramen ovale have been suggested, but there are insufficient data to confirm the situation. Studies have also not investigated detailed morphological changes in the fossa ovalis by ...
Linalyl acetate exerts analgesic effects by inhibiting nociceptive TRPA1 in mice [0.03%]
肉桂酸乙酯通过在小鼠中抑制伤害性TRPA1产生镇痛作用
Miho Hashimoto,Kenji Takahashi,Toshihiro Unno et al.
Miho Hashimoto et al.
Clary sage essential oil (CSEO) is utilized in perfumery, aromatherapy, and skincare. Linalyl acetate (LA), a primary component of CSEO, possesses sedative, anxiolytic, and analgesic properties. However, the mechanism of its analgesic actio...
Blockade of CD80/CD86-CD28 co-stimulation augments the inhibitory function of peptide antigen-specific regulatory T cells [0.03%]
阻断CD80/CD86-CD28协同刺激可增强肽特异性调节性T细胞的抑制功能
Yui Maehara,Kazuyoshi Takeda,Kyoko Tsuji-Yogo et al.
Yui Maehara et al.
Mixed lymphocyte culture under the blockade of CD80/CD86-CD28 co-stimulation induces anergic (completely hyporesponsive) T cells with immune suppressive function (inducible suppressing T cells: iTS cells). Previously, iTS cell therapy has d...
Calcium phosphate controls nucleation and growth of calcium oxalate crystal phases in kidney stones [0.03%]
磷酸钙控制肾结石中草酸钙晶体相的成核和生长
Uta Michibata,Mihoko Maruyama,Yutaro Tanaka et al.
Uta Michibata et al.
Kidney stone disease is a serious disease due to the severe pain it causes, high morbidity, and high recurrence rate. Notably, calcium oxalate stones are the most common type of kidney stone. Calcium oxalate appears in two forms in kidney s...
Using hemoglobin vesicles to treat operative hemorrhagic shock after pneu- monectomy in dog models: an experimental study [0.03%]
用人血红蛋白-vesicle治疗犬肺叶切除术后出血性休克的实验研究
Kei Nakano,Mitsutomo Kohno,Hiroto Onozawa et al.
Kei Nakano et al.
Hemoglobin vesicles (HbVs), considered as red blood cell substitutes, are liposomes encapsulating purified hemoglobin, with a phospholipid bilayer membrane (diameter: 250 nm; P50, 28 Torr). In this study, we aimed to investigate HbV functio...