Gastric biopsy-derived cell line and its utility in assessing tumor cell drug sensitivity [0.03%]
胃黏膜活检衍生细胞系及其在评估肿瘤细胞药物敏感性方面的应用价值
Masato Hayashi,Rei Noguchi,Makoto Abe et al.
Masato Hayashi et al.
Gastric cancer (GC) has benefited from treatment improvements such as minimally invasive surgery, molecular-targeted drugs, and immune check point inhibitors. However, the prognosis of advanced GC is still unfavorable. Minimally invasive pr...
Green coffee bean extract rich in chlorogenic acids prevents muscle capillary regression via inhibiting oxidative stress and enhancing angiogenesis [0.03%]
富含绿咖啡豆提取物氯原酸通过抑制氧化应激和促进血管生成来预防肌肉微血管退行性改变
Jihao Xing,Hao Lin,Ryosuke Nakanishi et al.
Jihao Xing et al.
Reactive oxygen species (ROS) production in disused skeletal muscle induces capillary regression, which disrupts the balance of pro- and anti-angiogenic factors. We tested whether green coffee bean extract containing rich chlorogenic acid, ...
Mycophenolate mofetil reduces cell viability associated with the miR-205-PAX9 pathway in human lip fibroblast cells [0.03%]
麦考酚酸莫耶酯通过miR-205-PAX9信号途径降低人唇成纤维细胞活力
Hiroki Yoshioka,Hanane Horita,Yosuke Tsukiboshi et al.
Hiroki Yoshioka et al.
Cleft lip is a birth defect associated with environmental and genetic factors. Recently, microRNAs (miRNAs) have been reported to play a crucial role in lip formation, with the disruption of miRNAs influencing the development of cleft lip. ...
Propranolol and landiolol inhibit cell proliferation enhanced by noradrenaline in human lung adenocarcinoma cells [0.03%]
普萘洛尔和兰尼洛尔抑制去甲肾上腺素促进的人肺腺癌细胞增殖
Masahiro Tomihari,Masae Iwasaki,Masashi Ishikawa
Masahiro Tomihari
Previous clinical data have shown that perioperative β-blocker administration can improve lung cancer prognosis, possibly by blocking autonomic nervous system responses. This study aimed to investigate the anticancer mechanisms of the β-b...
Modulation of myocardial injury in polymicrobial sepsis: The dual role of interleukin-13 in cardiac inflammation and stress [0.03%]
多微生物感染性休克中心肌损伤的调节：白细胞介素-13在心脏炎症和应激中的双重作用
Tsuyoshi Suzuki,Natsuo Yamamoto,Rie Zenda et al.
Tsuyoshi Suzuki et al.
Polymicrobial sepsis is associated with a poor prognosis due to severe type-1 innate inflammation triggered by immune cells, such as dendritic cells and macrophages. This immune response frequently leads to damage in the heart. Although int...
Serotonin reuptake inhibitor suppresses the activation of human platelets by a combination of thrombopoietin and collagen through inhibition of Rac and Rho/Rho-kinase [0.03%]
血小板衍生生长因子通过活化Rac和Rho小G蛋白诱导内皮细胞迁移及参与血管新生
Haruhiko Tokuda,Takamitsu Hori,Takashi Onuma et al.
Haruhiko Tokuda et al.
Tramadol and duloxetine, reuptake inhibitors of serotonin and noradrenaline, are widely used analgesics. Cytoplasmic serotonin in human platelets reportedly regulates the activity of low-molecular-weight GTP-binding proteins via serotonylat...
Analgesic effects of linalyl acetate via nociceptive TRPV1 inhibition in mice [0.03%]
牻牛儿醇乙酸酯通过抑制小鼠伤害性感觉的TRPV1产生镇痛作用
Miho Hashimoto,Kenji Takahashi,Toshio Ohta
Miho Hashimoto
Transient receptor potential vanilloid 1 (TRPV1) is primarily expressed in sensory neurons and functions as a nociceptive channel. TRPV1 is activated by capsaicin, acidic pH, and noxious heat. Compounds inhibiting TRPV1 have been explored t...
Efficacy of 1,5-anhydro-D-fructose on reducing mental stress: a randomized, double-blind, placebo-controlled trial-a pilot study [0.03%]
1,5-脱氢-D-果糖减压作用的随机双盲安慰剂对照试验——一项试点研究
Kiyoshi Kikuchi,Ryoji Kiyama,Kazuhiro Yoshinaga
Kiyoshi Kikuchi
Brain-derived neurotrophic factor (BDNF) plays an important role in mental stress. We have previously reported that 1,5-anhydro-D-fructose (1,5-AF) increases brain BDNF in vivo. The present randomized, controlled, double-blind study aimed t...
Randomized Controlled Trial
Biomedical research (Tokyo, Japan). 2024;45(5):209-216. DOI:10.2220/biomedres.45.209 2024
Quercetin protects human coronary artery endothelial cells against hypoxia/reoxygenation-induced mitochondrial apoptosis via the Nrf2/HO-1 axis [0.03%]
染料木素通过Nrf2/HO-1信号轴抑制缺氧/复氧诱导的人冠状动脉内皮细胞线粒体凋亡
Jiejin Song,Shuang Li,Boyong Zhang et al.
Jiejin Song et al.
Our study explored the therapeutic effect and the mechanism of quercetin against hypoxia/reoxygenation (H/R)-induced injury in human coronary artery endothelial cells (CAECs). Quercetin was selected as a potential component for the BuShenKa...
Bone regeneration-enhancing effects of extremely low-frequency electromag- netic fields: Analysis using fish scales as a bone model [0.03%]
极低频电磁场促骨再生作用的分析及其鱼鳞骨模型的研究
Nobuo Suzuki,Makiko Kakikawa,Yuta Oda et al.
Nobuo Suzuki et al.
Electromagnetic fields (EMFs) noninvasively promote fracture healing, prevent osteoporosis, promote diaphyseal growth, enhance differentiation, and stimulate cell division. However, no good model systems for analyzing bone regeneration have...