Chemical recognition of phytochemicals and microbiota-derived metabolites in the gut and implication for physiological function in the body [0.03%]
肠道中植物化学物质和微生物菌群衍生代谢物的化学识别及其对体内生理功能的影响
Atsukazu Kuwahara
Atsukazu Kuwahara
The gastrointestinal (GI) tract serves as a dynamic chemosensory interface that integrates signals from dietary phytochemicals and microbiota-derived metabolites to regulate host physiology. Beyond digestion and absorption, specialized epit...
Micheliolide alleviates oxygen-glucose deprivation/reoxygenation-evoked inflammation and ROS production in H9c2 cells [0.03%]
米契立醇通过减轻H9c2细胞中葡萄糖和氧气剥夺/复氧引起的炎症及ROS产生发挥保护作用
Qu Jin,Jinzhu Yin,Zhaozheng Liu et al.
Qu Jin et al.
Myocardial ischemia/reperfusion (I/R) injury can lead to substantial cardiac damage and pose a significant threat to human health and survival. Micheliolide (MCL), a sesquiterpene lactone extracted from Michelia (Magnoliaceae), has been rep...
Distribution and possible function of transient receptor potential melastatin-7 in the rat cranial sensory ganglia [0.03%]
大鼠颅神经感觉ganglion中瞬时受体电位锚蛋白7的分布及可能功能
Hiroka Tsumaki,Tomohiro Fukunaga,Kaori Takahashi et al.
Hiroka Tsumaki et al.
The distribution of transient receptor potential melastatin 7 (TRPM7) was investigated in the trigeminal (TG), petrosal (PG), jugular (JG), and nodose ganglia (NG) in a rat model. Approximately half of the sensory neurons contained TRPM7-im...
Muscular USP2 is dispensable for MASLD-associated disorders in the liver and skeletal muscle in mice [0.03%]
USP2的肌细胞功能与肝脏和骨骼肌MASLD相关障碍发展的关系较小
Aya Iida,Masaki Fujimoto,Hiroshi Kitamura
Aya Iida
We investigated the roles of muscular ubiquitin-specific protease (USP) 2 in the integrity of liver and muscle in metabolic dysfunction-associated steatotic liver disease (MASLD) using a mouse model. Choline-deficient, L-amino acid-defined,...
Fatty amines and 1-monoglycerides with cytotoxic activity serve as ligands for a multipurpose receptor CD36 [0.03%]
具有细胞毒活性的脂肪胺和1-单甘油酯是多功能受体CD36配体
Satoshi Tsuzuki,Masayuki Yamasaki,Tatsuya Sugawara et al.
Satoshi Tsuzuki et al.
Cluster of differentiation 36 (CD36) is a cell-surface receptor that exhibits multifunctional properties with diverse ligands. A short segment of CD36, consisting of amino acids 149-168 (CD36149-168), has been shown to constitute a site for...
Remimazolam and dexmedetomidine prevent cognitive decline by affecting lipopolysaccharide-induced brain injury in mice: Possible involvement of the vagus nerve pathway [0.03%]
瑞米扎莫尔和右美托咪啶通过影响脂多糖诱导的小鼠脑损伤预防认知衰退：迷走神经通路的可能作用
Wei Wang,Yosuke Uchida,Yuji Morimoto
Wei Wang
Sepsis-associated encephalopathy (SAE) is a critical neurological complication of sepsis with limited therapeutic options. This study investigated the neuroprotective potential of remimazolam (REMI) and dexmedetomidine (DEX) in a lipopolysa...
The translocator protein ligand Ro5-4864 inhibits RANKL-induced osteoclastogenesis in mice [0.03%]
Ro5-4864抑制鼠类RANKL诱导的破骨细胞生成作用
Nobutaka Matsuura,Kazuyoshi Takeda,Yuka Sendai et al.
Nobutaka Matsuura et al.
The translocator protein (TSPO) is a mitochondrial outer membrane protein that is constitutively expressed in various immune cells, including macrophages, dendritic cells, T cells, and B cells. TSPO has been implicated in mitochondrial func...
Age-dependent changes of the perineuronal net in the mouse basal ganglia nuclei [0.03%]
小鼠基底神经节核团中随年龄变化的围神经细胞网状结构的变化规律
Fuyuki Karube,Linsen Lu,Fumino Fujiyama
Fuyuki Karube
Aging promotes mild but progressive decline of motor behaviors and cognitive functions, related to loss of plasticity. Recovery of neural plasticity may become a possible clinical treatment against aging. Perineuronal net (PNN) is the extra...
Methionine oxidation of TRPV2 regulates thermogenesis in brown adipocytes [0.03%]
蛋氨酸氧化反应在TRPV2调节棕色脂肪细胞产热中的作用
Mari Iwase,Satoko Kawarasaki,Tsuyoshi Goto et al.
Mari Iwase et al.
Transient receptor potential vanilloid 2 (TRPV2) is a non-selective cation channel activated by mechanical stimuli and temperatures above 52°C. Although we have previously reported that TRPV2 regulates non-shivering thermogenesis through f...
Disturbance on drug efficacy of dapagliflozin, an SGLT2 inhibitor, in mice [0.03%]
钠-葡萄糖协同转运蛋白2抑制剂达格列净的干扰研究小鼠效力障碍
Hiroki Yoshioka,Fumiya Amano,Aiko Yano et al.
Hiroki Yoshioka et al.
This study aimed to investigate the efficacy of dapagliflozin administration time using light-dark cycle-disrupted mice. Five-week-old male C57BL/6J mice were fed a control diet or high-fat diet (HFD) for 8-weeks under a disrupted light-dar...