Multihormone-producing capabilities of normal pancreatic islet cells-spatial transcriptomics analysis using Xenium [0.03%]
正常胰岛细胞的多激素分泌能力-Xenium空间转录组分析
Akane Naruoka,Ken Yamaguchi,Takashi Sugino et al.
Akane Naruoka et al.
The aim of this study is to clarify whether adult pancreatic islet cells would strictly maintain the ability to produce a single pancreatic hormone, or whether they would retain the plasticity to produce two or more pancreatic hormones simu...
The distinct effect between Amyloid β (1‒40) and Amyloid β (1‒42) on the TRAP-stimulated platelet activation in diabetes mellitus [0.03%]
糖尿病患者血小板活化过程中淀粉样蛋白β（1-40）和淀粉样蛋白β（1-42）的不同影响
Takuya Omura,Chika Usui,Rie Matsushima-Nishiwaki et al.
Takuya Omura et al.
Amyloid β (Aβ) (1‒40) is the major form in amyloid plaques, while Aβ (1‒42) is predominant in neuronal plaques. Anti-Aβ antibodies are clinically accepted for Alzheimer's disease treatment to remove Aβ from neuronal plaques; however,...
Pro-gastrin-releasing peptide expression in Ewing sarcoma cells in vitro and in vivo demonstrates its availability as a valuable tumor marker [0.03%]
异位表达胃泌素释放肽在尤因肉瘤细胞中的体内外研究证实其可作为有价值的肿瘤标志物
Kouji Maruyama,Koji Muramatsu,Hidee Ishii et al.
Kouji Maruyama et al.
Pro-gastrin-releasing peptide (ProGRP) is the precursor of gastrin-releasing peptide (GRP), a neuropeptide hormone with diverse biological activities. ProGRP is an established tumor marker for small cell lung carcinoma (SCLC). Recently, we ...
The balance among radiation-induced cell death pathways in the p53-mutant human glioblastoma cell line T98G: A preliminary study [0.03%]
p53突变的人胶质母细胞瘤T98G细胞系中放射诱导的各条死亡通路之间的平衡：初步研究
Hisashi Nakano,Juri Kidachi,Mitsuki Imazato et al.
Hisashi Nakano et al.
The specific contributions of apoptosis, necrosis, autophagy, and cellular senescence pathways in malignant tumor cells (especially p-53 defective or mutated tumors) are unclear. We evaluated the cell viability, apoptosis, autophagic cell d...
Changes in 5-hydroxytryptamine and its metabolite, 5-hydroxyindole-acetic acid, levels in the brain of rats administered with methotrexate [0.03%]
甲氨蝶呤干预大鼠脑内5-羟色胺及其代谢产物5-羟吲哚乙酸水平的变化
Sachiko Hiraide,Takuji Machida,Mina Yamada et al.
Sachiko Hiraide et al.
During the delayed emesis phase, methotrexate tended to increase 5-hydroxytryptamine (5-HT) levels in midbrain and significantly increased 5-hydroxyindole-acetic acid (5-HIAA), a metabolite of 5-HT, levels in the area postrema and in the ce...
The mouse experimental periodontitis by silk-ligature placement triggers systemic inflammation potentially exacerbating pulmonary inflammation [0.03%]
丝线结扎诱导的小鼠实验性牙周炎引发全身炎症或加重肺部炎症反应
Shingo Kawai,Hiroyuki Oguchi,Mayumi Endo et al.
Shingo Kawai et al.
Periodontitis, a chronic inflammatory disease driven by oral microbiota dysbiosis, is associated with systemic diseases; however, the mechanisms remain poorly understood. Using a silk-ligation-induced periodontitis mouse model, we investiga...
Intragastric administration of cuminaldehyde, a natural TRPA1 agonist, enhanced carbohydrate oxidation and reduced body fat accumulation in mice [0.03%]
胃内给药肉桂醛，一种TRPA1激动剂，增强小鼠碳水化合物氧化并减少体内脂肪积累
Fuminori Kawabata,Ren Fukai,Taiga Miyagi et al.
Fuminori Kawabata et al.
Transient receptor potential ankyrin 1 (TRPA1) is a nociceptive receptor activated by chemical compounds such as allyl isothiocyanate, cinnamaldehyde, and carvacrol, found in spices and herbs. Since the intake of some TRPA1 agonists inhibit...
Possible involvement of neuropeptide Y sub-receptor 1 (NPY-Y1) in the anti-viral response of SARS-CoV-2 infection in Syrian hamster [0.03%]
神经肽Y亚受体1(NPY-Y1)可能参与了叙利亚仓鼠SARS-CoV-2感染的抗病毒反应
Haruka Nishimura,Kohei Araki,Chihomi Mitsuoka et al.
Haruka Nishimura et al.
Co-administration of Molnupiravir and Remdesivir, treatments for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), inhibits viral replication and infectivity. Previous studies indicate that the neuropeptide Y sub-receptor 1 (NPY...
Mitochondrial DNA copy number variations in Epstein-Barr virus-transformed B cells after exposure to radiation: A possible biomarker for dose assessment [0.03%]
放射线照射后的EB病毒转化的B细胞中线粒体DNA拷贝数的变化：可能用于剂量评估的生物标志物
Hitomi Muramatsu,Ryosuke Seino,Hisanori Fukunaga
Hitomi Muramatsu
Following accidental radiation exposure due to a radiological or nuclear emergency, a dose assessment should be performed based on biological samples from exposed individuals. Although previous biological dose assessment approaches have foc...