Serum cell-free DNA concentration as a possible prognostic marker in newly diagnosed diffuse large B-cell lymphoma [0.03%]
新诊断弥漫大B细胞淋巴瘤患者血清游离DNA浓度的预后价值研究
Yuko Shirouchi,Yuko Mishima,Tomoko Takayama et al.
Yuko Shirouchi et al.
Cell-free DNA (cfDNA) is a fragment of DNA circulating in the blood, and its concentration is often elevated in cancer patients. To investigate the relationships between serum cfDNA concentration and clinical characteristics, including prog...
Early reperfusion with hemoglobin vesicles into tracheal subepithelial capillaries in a mouse tracheal transplant model [0.03%]
在小鼠气管移植模型中通过气管亚上皮微血管早期再灌注输运血红蛋白囊泡
Hiroto Onozawa,Mitsutomo Kohno,Ryo Hashimoto et al.
Hiroto Onozawa et al.
Hemoglobin vesicles (HbVs), liposomes containing concentrated hemoglobin extracted from outdated human red blood cells (RBC), are artificial oxygen carriers with a small particle size. To evaluate the reperfusion of capillaries with HbVs in...
Effects of ANP and BNP on the generation of respiratory rhythms in brainstem-spinal cord preparation isolated from newborn rats [0.03%]
心房利钠肽和脑利钠肽对新生大鼠延髓脊髓分离制备呼吸节律的影响
Shino Katsuki,Shinichiro Ota,Shunya Yoda et al.
Shino Katsuki et al.
Natriuretic peptides (NPs) are a family of peptide hormones produced in cardiac muscle cells and consist mainly of three types: atrial NP (ANP), B-type (or brain) NP (BNP), and C-type NP. We herein report the effects of ANP and BNP on centr...
Development of two 410-cancer-gene panel tests for solid tumors and liquid biopsy based on genome data of 5,143 Japanese cancer patients [0.03%]
基于日本5,143名癌症患者基因组数据的两种固体肿瘤和液体活检410个癌基因检测的研发
Yuji Shimoda,Takeshi Nagashima,Kenichi Urakami et al.
Yuji Shimoda et al.
Next-generation sequencing (NGS) is an integral part of precision medicine, and its power for detecting comprehensive genetic alterations may contribute to treatment decisions for patients with advanced, recurrent, or metastatic cancer. An ...
Novel cell-based system to assay cell-cell fusion during myotube formation [0.03%]
一种全新的细胞融合分析系统用于检测肌管形成过程中的细胞融合现象
Mari Isobe,Yumika Suzuki,Hideshi Sugiura et al.
Mari Isobe et al.
A live assay tool has been established to uncover the precise molecular mechanisms underlying complex cell fusion events in myoblasts. The novel cell-based assay, HiMy (HiBiT-based myoblast fusion), utilizes a recently developed split-lucif...
Meis1 plays roles in cortical development through regulation of cellular proliferative capacity in the embryonic cerebrum [0.03%]
Meis1通过调节胚胎大脑的细胞增殖能力在皮层发育中发挥作用
Eriko Isogai,Kazuhiro Okumura,Megumi Saito et al.
Eriko Isogai et al.
Meis1 (myeloid ecotropic insertion site 1) is known to be related to embryonic development and cancer. In this study, to analyze the function of Meis1 in neural stem cells, we crossed Meis1fl/fl (Meis1 floxed) mice with Nestin-Cre mice. The...
Ca2+-based neural activity recording for rapidly screening behavioral correlates of the claustrum in freely behaving mice [0.03%]
基于钙离子的神经活动记录快速筛查自由行为小鼠脑隔区相关行为学表型关联性
Jing Qin,Wu-Shuang Huang,Hao-Ran DU et al.
Jing Qin et al.
The claustrum has been hypothesized to participate in high-order brain functions, but experimental studies to demonstrate these functions are currently lacking. Neural activity recording of the claustrum in freely-behaving animals allows fo...
Shotgun proteomic investigation of methyltransferase and methylation profiles in lipopolysaccharide stimulated RAW264.7 murine macrophages [0.03%]
利用基因转移蛋白质组学方法研究脂多糖刺激的小鼠RAW264.7巨噬细胞甲基化酶及甲基化图谱
Yumi Aizawa,Masaru Mori,Tsukasa Suzuki et al.
Yumi Aizawa et al.
Arginine methylation is a common post-translational modification which functions as an epigenetic regulator of transcription and plays a key role in various cell signaling pathways. The methylation of arginine residues is catalyzed by prote...
Disposal of intestinal apoptotic epithelial cells and their fate via divergent routes [0.03%]
肠上皮凋亡细胞的清除及其迥异的命运
Toshihiko Iwanaga,Hiromi Takahashi-Iwanaga
Toshihiko Iwanaga
Gut epithelial cells are characterized by rapid, constant cell renewal. The disposal of aging epithelial cells around the villus tips of the small intestine occurs so regularly that it has been regarded as a consequence of well-controlled c...
Suncus murinus as a novel model animal that is suitable for elucidating the mechanism of daily torpor [0.03%]
Suncus murinus作为用于阐明日常蛰眠机制的新模型动物
Yuuki Horii,Kanako Okadera,Shingo Miyawaki et al.
Yuuki Horii et al.
Torpor, a state of lowered body temperature due to active reduction of the metabolic rate, has potential medical benefits. The aim of this study was to establish a novel laboratory animal that enter torpor without imposing complex condition...