Casting Light on Life [0.03%]
生命闪光
Atsushi Miyawaki
Atsushi Miyawaki
The behavior of biochemical molecules moving around in cells makes me think of a school of whales wandering in the ocean, captured by the Argus system on the artificial satellite. When bringing a whale back into the sea --- with a transmitt...
Aviv Regev
Aviv Regev
The recent advent of methods for high-throughput single-cell and spatial profiling have opened the way to complete the 150-year-old endeavor of identifying all cell types in the human body, by their distinctive molecular profiles, and to re...
Iori Kisu,Kouji Banno,Yusuke Matoba et al.
Iori Kisu et al.
Uterus transplantation (UTx) has seen increasing global adoption as an alternative for women with uterine factor infertility to achieve pregnancy. However, several medical, ethical, and social issues need to be addressed before UTx can be a...
Hospital Preparedness for COVID-19: The Known and The Known Unknown [0.03%]
医院对新型冠状病毒肺炎的应对准备：已知和未知的准备
Daiki Kaito,Kazuki Matsumura,Ryo Yamamoto
Daiki Kaito
In late March 2020, we faced a nosocomial outbreak of novel coronavirus disease 2019 (COVID-19) at Keio University Hospital, Tokyo, Japan. Presently, COVID-19 is an unprecedented worldwide biohazard, and a nosocomial outbreak can occur in a...
Development of Cardiac Regenerative Medicine Using Human iPS Cell-derived Cardiomyocytes [0.03%]
利用人iPS源心脏细胞开发心脏再生医学
Jun Fujita
Jun Fujita
Heart failure is a life-threatening disease prevalent worldwide. Cardiac transplantation is the last resort for patients with severe heart failure, but donor shortages represent a critical issue. Cardiac regenerative therapy is beneficial, ...
Syndrome of Inappropriate Secretion of Antidiuretic Hormone Caused by Very Short-term Use of Proton Pump Inhibitor [0.03%]
质子泵抑制剂短期应用所致的抗利尿激素异常分泌综合征
Sae Aratani,Takeshi Matsunobu,Takahiro Kawai et al.
Sae Aratani et al.
Proton pump inhibitors (PPIs) are widely used medicines worldwide. However, a rare etiology of syndrome of inappropriate secretion of antidiuretic hormone (SIADH) related to PPI was recently reported. Therefore, the putative role of PPIs in...
Antifungal Agent Luliconazole Inhibits the Growth of Mouse Glioma-initiating Cells in Brain Explants [0.03%]
抗真菌剂Luliconazole抑制脑组织移植物中鼠胶质母细胞瘤起始细胞的生长
Hideaki Nagashima,Naoyoshi Koike,Kazunari Yoshida et al.
Hideaki Nagashima et al.
Imidazole antifungal compounds exert their antipathogenic effects through inhibition of sterol biosynthesis. These drugs have also recently been identified as candidate anticancer agents for several solid tumors including glioblastoma. Howe...
Recent Advances in the Definition and Management of Functional Dyspepsia [0.03%]
近期关于功能性消化不良定义和治疗的进展
Hidekazu Suzuki
Hidekazu Suzuki
In 2016, the Rome criteria were updated as Rome IV, and only minor changes were introduced for functional dyspepsia (FD). The major symptoms of FD now include not only postprandial fullness, but also epigastric pain and burning, and early s...
Seitaro Fujishima
Seitaro Fujishima
Juntaro Matsuzaki,Takahiro Ochiya
Juntaro Matsuzaki
Early detection of cancer is crucial for its ultimate control and the prevention of malignant progression. In Japan, a nationwide project was conducted between 2014 and 2019 to develop novel cancer detection tools using serum microRNAs (miR...