The Unlikely Development of CAR T Cells: a Brief History and Prospects for the Future [0.03%]
CAR-T细胞疗法的前世今生：历史回顾与未来展望
Carl H June
Carl H June
The quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. C...
Multiple Mutations within Individual Oncogenes: Examples and Clinical Implications [0.03%]
单个癌基因内的多个突变：实例与临床意义
Keisuke Kataoka,Yuki Saito
Keisuke Kataoka
Gain-of-function mutations had been believed to function as a single mutation in oncogenes, although some secondary mutations, such as EGFR T790M mutations, are frequently acquired in patients that are resistant to tyrosine kinase inhibitor...
Network Approaches to Uncover Pathogenesis and Therapeutic Targets of Inflammatory Bowel Diseases [0.03%]
网络方法揭示炎症性肠病发病机制和治疗靶点
Yohei Mikami,Takanori Kanai
Yohei Mikami
Inflammatory bowel diseases (IBD) are currently recognized to involve chronic intestinal inflammation in genetically susceptible individuals. Patients with IBD mainly develop gastrointestinal inflammation, but it is sometimes accompanied by...
Clinical Complete Response of Recurrent Gastric Cancer after Third-line CPT-11 Chemotherapy [0.03%]
三线使用伊立替康治疗的胃癌复发灶的临床完全消失
Masato Hayashi,Takeshi Fujita,Hisayuki Matsushita
Masato Hayashi
A 75-year-old man underwent distal gastrectomy for advanced gastric cancer in September 2018. During the adjuvant chemotherapy, computed tomography (CT) revealed recurrence sites in the liver and para-aortic lymph nodes. Therefore, chemothe...
Pupil Dynamics-derived Sleep Stage Classification of a Head-fixed Mouse Using a Recurrent Neural Network [0.03%]
基于 pupil dynamics 的小鼠睡眠分期及其递归神经网络模型
Goh Kobayashi,Kenji F Tanaka,Norio Takata
Goh Kobayashi
The standard method for sleep state classification is thresholding the amplitudes of electroencephalography (EEG) and electromyography (EMG) data, followed by manual correction by an expert. Although popular, this method has some shortcomin...
Masayuki Akashi
Masayuki Akashi
Food protein-induced enterocolitis syndrome (FPIES) is a type of non-IgE-mediated gastrointestinal food allergy. FPIES is characterized by repetitive vomiting without classic IgE-mediated allergic skin or respiratory symptoms 1-4 h after ca...
Reoperative Aortic Valve Replacement for Structural Valve Deterioration through a Lower Hemisternotomy after a Previous Bentall Procedure in a Patient with Tracheostomy [0.03%]
之前接受过Bentall手术的气管切开术患者经下部半胸骨劈开术治疗主动脉瓣置换术后结构瓣衰败
Kaori Katsumata,Yujiro Kawai,Tsutomu Ito et al.
Kaori Katsumata et al.
Patients with tracheostomy who undergo a full sternotomy have an increased risk of mediastinitis and sternal infection. This report describes a reoperative aortic valve replacement (re-AVR) for structural valve deterioration (SVD) through a...
Age Group Differences in Daily Life Changes among Community Residents during the COVID-19 Pandemic: A Pilot Study on Intergenerational Comparison [0.03%]
COVID-19疫情期间社区居民日常生活变化的年龄差异：一项代际比较的初步研究
Natsuki Yamamoto-Takiguchi,Eiko Uchiyama,Hiroki Fukahori et al.
Natsuki Yamamoto-Takiguchi et al.
This study investigated lifestyle changes and the self-reported mental health status of Japanese community residents during the COVID-19 pandemic. Differences in demography, daily lifestyle changes, and approaches to problem solving were an...
Shinya Sugimoto,Eiji Kobayashi,Takanori Kanai et al.
Shinya Sugimoto et al.
Our understanding of the biology of the intestinal epithelium has advanced since the establishment of an organoid culture system. Although organoids have enabled investigation of the mechanism of self-renewal of human intestinal stem cells ...
Targeting Tumor Microenvironment in Liver Cancers: Rationale, Current Progress, and Future Perspective [0.03%]
肝癌肿瘤微环境治疗的理性思考、现状及未来展望
Dan G Duda
Dan G Duda
Surgical treatments offer the chance for cure in primary or metastatic liver cancers. However, many patients experience disease progression after surgical interventions, or cannot undergo surgery as they present with unresectable disease at...