Kenta Maruyama
Kenta Maruyama
The sensory and immune systems have been studied independently for a long time, whereas the interaction between the two has received little attention. We have carried out research to understand the interaction between the sensory and immune...
Yutaka Shimomura
Yutaka Shimomura
The hair follicle is an appendage of the skin that undergoes hair cycles throughout life. Recently, numerous genes expressed in the hair follicles have been identified, and variants in some of these genes are now known to underlie hereditar...
Recent Advances in Clinical Research on Rare Intractable Hereditary Skin Diseases in Japan [0.03%]
日本难治性遗传性皮肤罕见病的临床研究新进展
Masashi Akiyama,Takuya Takeichi,Shigaku Ikeda et al.
Masashi Akiyama et al.
Our Research Group for Rare and Intractable Skin Diseases operates within the Project for Research on Intractable Diseases of the Ministry of Health, Labour, and Welfare of Japan and is conducting research on eight rare intractable skin dis...
Targeting DNA Methylation in Podocytes to Overcome Chronic Kidney Disease [0.03%]
靶向系膜细胞DNA甲基化以克服慢性肾脏疾病
Kaori Hayashi
Kaori Hayashi
The number of patients with chronic kidney disease (CKD) is on the rise worldwide, and there is urgent need for the development of effective plans against the increasing incidence of CKD. Podocytes, glomerular epithelial cells, are an integ...
Yoshihiro Kawaoka
Yoshihiro Kawaoka
Emerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host resp...
The Unlikely Development of CAR T Cells: a Brief History and Prospects for the Future [0.03%]
CAR-T细胞疗法的前世今生：历史回顾与未来展望
Carl H June
Carl H June
The quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. C...
Multiple Mutations within Individual Oncogenes: Examples and Clinical Implications [0.03%]
单个癌基因内的多个突变：实例与临床意义
Keisuke Kataoka,Yuki Saito
Keisuke Kataoka
Gain-of-function mutations had been believed to function as a single mutation in oncogenes, although some secondary mutations, such as EGFR T790M mutations, are frequently acquired in patients that are resistant to tyrosine kinase inhibitor...
Network Approaches to Uncover Pathogenesis and Therapeutic Targets of Inflammatory Bowel Diseases [0.03%]
网络方法揭示炎症性肠病发病机制和治疗靶点
Yohei Mikami,Takanori Kanai
Yohei Mikami
Inflammatory bowel diseases (IBD) are currently recognized to involve chronic intestinal inflammation in genetically susceptible individuals. Patients with IBD mainly develop gastrointestinal inflammation, but it is sometimes accompanied by...
Clinical Complete Response of Recurrent Gastric Cancer after Third-line CPT-11 Chemotherapy [0.03%]
三线使用伊立替康治疗的胃癌复发灶的临床完全消失
Masato Hayashi,Takeshi Fujita,Hisayuki Matsushita
Masato Hayashi
A 75-year-old man underwent distal gastrectomy for advanced gastric cancer in September 2018. During the adjuvant chemotherapy, computed tomography (CT) revealed recurrence sites in the liver and para-aortic lymph nodes. Therefore, chemothe...
Pupil Dynamics-derived Sleep Stage Classification of a Head-fixed Mouse Using a Recurrent Neural Network [0.03%]
基于 pupil dynamics 的小鼠睡眠分期及其递归神经网络模型
Goh Kobayashi,Kenji F Tanaka,Norio Takata
Goh Kobayashi
The standard method for sleep state classification is thresholding the amplitudes of electroencephalography (EEG) and electromyography (EMG) data, followed by manual correction by an expert. Although popular, this method has some shortcomin...