The Keio HBOC Center: A Model of Hereditary Breast and Ovarian Cancer Management [0.03%]
庆应义塾大学HBOC中心：遗传性乳腺癌和卵巢癌管理的典范
Yusuke Kobayashi,Kenta Masuda,Tomoko Seki et al.
Yusuke Kobayashi et al.
The management of hereditary breast and ovarian cancer (HBOC) in Japan has changed drastically with the expansion of indications for poly ADP-ribose polymerase inhibitors, the increase in diagnostic opportunities with the spread of companio...
Community Pharmacists' Perceptions and Needs Regarding Oral Healthcare Advice in Japan [0.03%]
日本药房从业人员关于口腔保健意识和需求的调查
Hiroki Iwata,Rintaro Yoshida,Naoko Hayashi et al.
Hiroki Iwata et al.
It is desirable for community pharmacists to be involved in promoting and maintaining the oral health of local residents. In this study, we conducted a questionnaire survey of Japanese community pharmacists to understand the actual conditio...
Pemphigus: An Autoimmune Disease Model for Understanding the Role of Autoreactive T Cells [0.03%]
自身免疫病 pemphigus 与自反应性T细胞的作用机制研究
Hayato Takahashi
Hayato Takahashi
Finding cures is the ultimate goal of research on autoimmune diseases. Pemphigus is an autoantibody-mediated autoimmune skin disease in which specific autoantibodies target desmogleins 1 and 3 as autoantigens. The condition leads to painful...
Prognosis Prediction by 18F-fluorodeoxyglucose Positron Emission Tomography Parameters in Patients Undergoing Chemoradiation Therapy for Esophageal Cancer [0.03%]
化疗联合放疗的食管癌患者中氟脱氧葡萄糖正电子发射断层显像参数对其预后的预测价值
Yusuke Motomura,Junichi Fukada,Tadaki Nakahara et al.
Yusuke Motomura et al.
The aim of this study was to identify 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) parameters that could predict the prognosis of patients with esophageal cancer before and after undergoing chemor...
Diabetic Ketoacidosis as the Initial Presenting Symptom of Pancreatic Cancer: A Comprehensive Review [0.03%]
糖尿病酮症酸中毒作为胰腺癌的首发症状：全面回顾
Khaled Saad,Mustafa Mahmoud,Mahmoud M Younes et al.
Khaled Saad et al.
Recent studies have indicated that diabetic ketoacidosis (DKA) can be the primary presenting symptom of pancreatic cancer. This comprehensive review assesses the existing research on the incidence of DKA as an initial symptom of pancreatic ...
Pancreatic Cancer in Hereditary Breast and Ovarian Cancer Syndrome: Is Early Detection Possible? [0.03%]
遗传性乳腺癌和卵巢癌综合症中的胰腺癌：早期检测有可能吗？
Kodai Abe,Minoru Kitago,Yusuke Kobayashi et al.
Kodai Abe et al.
A program of recruiting families with hereditary pancreatic cancer and hereditary breast and ovarian cancer (HBOC) syndrome as high-risk individuals for pancreatic cancer surveillance using magnetic resonance cholangiopancreatography (MRCP)...
Exploring Breast Cancer Risk Management in HBOC Patients: Image Surveillance Versus Risk-reducing Surgery [0.03%]
遗传性乳腺癌卵巢癌患者风险评估和管理的研究：影像监测与预防性手术的比较
Tomoko Seki,Yusuke Kobayashi,Kenta Masuda et al.
Tomoko Seki et al.
In Japan, the rising incidence of hereditary breast and ovarian cancer syndrome (HBOC) follows partial insurance coverage introduced in 2020. Compared with the general population (~11% lifetime risk), individuals with HBOC face a significan...
Poorly Differentiated Carcinoma with only Clear Glandular Differentiation Arising from the Bladder Trigone: A Case of Adenocarcinoma or Urothelial Carcinoma? [0.03%]
仅表现出明显腺体分化的分化不良的 carcinoma 起源于三角膀胱区：是一例腺癌或尿路上皮癌？
Kaoru Furihata,Atsushi Kurabayashi,Waka Iwashita et al.
Kaoru Furihata et al.
Invasive urothelial carcinoma (UC) has diverse morphological presentations. Here, we describe the case of a Japanese woman aged in her early 60s with UC with unclear differentiation. The patient presented with distinct glandular differentia...
Current Situation and Future Directions of Risk-reducing Salpingo-oophorectomy [0.03%]
预防性卵巢输卵管切除术的现状及未来方向
Kenta Masuda,Yusuke Kobayashi,Tomoko Seki et al.
Kenta Masuda et al.
High-grade serous carcinoma (HGSC), the most aggressive subtype of epithelial ovarian cancer, is strongly associated with hereditary breast and ovarian cancer (HBOC) syndrome and is primarily linked to germline BRCA1/2 pathogenic variants (...
Pioneering the Future of Cancer Immunotherapy: A New Era of Synthetic Immunology through Computational Modeling [0.03%]
开拓癌症免疫治疗的未来：通过计算建模进入合成免疫学的新时代
Taisuke Kondo
Taisuke Kondo
Chimeric Antigen Receptor (CAR) T-cell immunotherapy has revolutionized the treatment of hematological malignancies. However, its application to solid tumors has been hindered by poor specificity and potential toxicity to healthy tissues. T...