Iminium ion metabolites are formed from nintedanib by human CYP3A4 [0.03%]
人CYP3A4代谢生成尼替尼引起的伊米鎓离子代谢产物形成
Shimon Nakashima,Tatsuki Fukami,Takashi Kudo et al.
Shimon Nakashima et al.
Nintedanib is used to treat idiopathic pulmonary fibrosis, systemic sclerosis, interstitial lung disease, and progressive fibrotic interstitial lung disease. It is primarily cleared via hepatic metabolism, hydrolysis, and glucuronidation. I...
Quantitative prediction of CYP3A induction-mediated drug-drug interactions in clinical practice [0.03%]
临床实践中CYP3A诱导型药物相互作用的定量预测
Haruka Tsutsui,Motohiro Kato,Shino Kuramoto et al.
Haruka Tsutsui et al.
There have been no reports on the quantitative prediction of CYP3A induction-mediated decreases in AUC and Cmax for drug candidates identified as a "victims" of CYP3A induction. Our previous study separately evaluated the fold-induction of ...
Kazuya Maeda,Masayo Oishi
Kazuya Maeda
Corrigendum to "Utility of Göttingen minipigs for the prediction of human pharmacokinetic profiles after intravenous drug administration" [Drug Metabol Pharmacokinet 41 (2021) 100408] [0.03%]
“哥廷根迷你猪对预测人类静脉给药后的药物动力学特征的适用性”的勘误( Drug Metab Pharmokinet 41 (2021) 100408 )
Ning Ding,Syunsuke Yamamoto,Ikumi Chisaki et al.
Ning Ding et al.
Published Erratum
Drug metabolism and pharmacokinetics. 2023 Apr 1:57:100508. DOI:10.1016/j.dmpk.2023.100508 2023
DMPK perspective on quantitative model analysis for chimeric antigen receptor cell therapy: Advances and challenges [0.03%]
嵌合抗原受体细胞治疗定量模型分析的药物代谢动力学视角：进展与挑战
Akihiko Goto,Yuu Moriya,Miyu Nakayama et al.
Akihiko Goto et al.
Chimeric antigen receptor (CAR) cells are genetically engineered immune cells that specifically target tumor-associated antigens and have revolutionized cancer treatment, particularly in hematological malignancies, with ongoing investigatio...
Beyond the basics: A deep dive into parameter estimation for advanced PBPK and QSP models [0.03%]
超越基础：高级PBPK和QSP模型参数估计的深入探讨
Kota Toshimoto
Kota Toshimoto
Physiologically-based pharmacokinetic (PBPK) models and quantitative systems pharmacology (QSP) models have contributed to drug development strategies. The parameters of these models are commonly estimated by capturing observed values using...
Insights into drug development with quantitative systems pharmacology: A prospective case study of uncovering hyperkalemia risk in diabetic nephropathy with virtual clinical trials [0.03%]
定量系统药理学在药物研发中的见解——通过虚拟临床试验发现糖尿病肾病患者用药后高钾血症风险的案例研究
Ryuta Saito,Tomohisa Nakada
Ryuta Saito
The quantitative systems pharmacology (QSP) approach is widely applied to address various essential questions in drug discovery and development, such as identification of the mechanism of action of a therapeutic agent, patient stratificatio...
Impact of miR-222-3p-mediated downregulation of arylacetamide deacetylase on drug hydrolysis and lipid accumulation [0.03%]
microRNA-222-3p通过下调芳基乙酰胺脱乙酰酶对药物水解及脂质累积的影响
Yoshiyuki Sakai,Tatsuki Fukami,Shinsaku Tokumitsu et al.
Yoshiyuki Sakai et al.
Arylacetamide deacetylase (AADAC) is involved in drug hydrolysis and lipid metabolism. In 23 human liver samples, no significant correlation was observed between AADAC mRNA (19.7-fold variation) and protein levels (137.6-fold variation), su...
Applications of model simulation in pharmacological fields and the problems of theoretical reliability [0.03%]
模型模拟在药学领域中的应用及其理论可靠性问题分析
Yoshiaki Kariya,Masashi Honma
Yoshiaki Kariya
The use of mathematical models has become increasingly prevalent in pharmacological fields, particularly in drug development processes. These models are instrumental in tasks such as designing clinical trials and assessing factors like effi...
Practical QSP application from the preclinical phase to enhance the probability of clinical success: Insights from case studies in oncology [0.03%]
从临床前阶段到增强临床成功的实用QSP应用见解：来自肿瘤学案例研究的启示
Masayo Oishi,Hiroyuki Sayama,Kota Toshimoto et al.
Masayo Oishi et al.
Quantitative Systems Pharmacology (QSP) has emerged as a promising modeling and simulation (M&S) approach in drug development, with potential to improve clinical success rates. While conventional M&S has significantly contributed to quantit...