Development and application of 3D cardiac tissues derived from human pluripotent stem cells [0.03%]
基于人多能干细胞的三维心脏组织的开发及其应用
Masatoshi Ohno,Hidenori Tani,Shugo Tohyama
Masatoshi Ohno
Recently human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) have become an attractive platform to evaluate drug responses for cardiotoxicity testing and disease modeling. Moreover, three-dimensional (3D) cardiac models, such as e...
Global expansion of microphysiological systems (MPS) and Japan's initiatives: Innovation in pharmaceutical development and path to regulatory acceptance [0.03%]
微型生理系统(MPS)的全球扩展及日本的倡议：药物开发中的创新及其监管认可之路
Daiju Yamazaki,Seiichi Ishida
Daiju Yamazaki
Microphysiological systems (MPS) are gaining global attention as potential game-changers in pharmaceutical development. Since 2013, MPS suppliers from university laboratories in the United States and Europe have competed to develop these de...
Development of intestinal organoids and microphysiological systems and their application to drug discovery [0.03%]
肠类器官和微生理系统的发展及其在药物发现中的应用
Takahiro Iwao,Tamihide Matsunaga
Takahiro Iwao
The intestines are an important organ with a variety of functions. For drug discovery research, experimental animals and Caco-2 cells derived from a human colon carcinoma may be used to evaluate the absorption and safety of orally administe...
Micro-physiological system of human lung: The current status and application to drug discovery [0.03%]
人肺微生理系统：现状与药物发现应用
Naoyuki Sone,Shimpei Gotoh
Naoyuki Sone
Various attempts have been made to elucidate the mechanisms of human lung development, its physiological functions, and diseases, in the hope of new drug discovery. Recent technological advancements in experimental animals, cell culture, ge...
Organoids and microphysiological systems for pharmaceutical research of viral respiratory infections [0.03%]
病毒性呼吸道感染药物研究的类器官和微生理系统
Sayaka Deguchi,Fuki Yokoi,Kazuo Takayama
Sayaka Deguchi
In the pharmaceutical research of viral respiratory infections, cell culture models have traditionally been used to evaluate the therapeutic effects of candidate compounds. Although cell lines are easy to handle and cost-effective, they do ...
The refined CYP2B6-Template system for studies of its ligand metabolisms [0.03%]
精制的CYP2B6模板体系用于研究其底物代谢
Yasushi Yamazoe,Kouichi Yoshinari
Yasushi Yamazoe
The previously reported Template system for the prediction of human CYP2B6-mediated reactions (Drug Metab Pharmacokinet 26 309-330, 2011) has been refined with the introduction of ideas of allowable width, Trigger-residue and the residue-in...
Population pharmacokinetics of blonanserin in Japanese adolescent and adult patients with schizophrenia [0.03%]
日籍青少年及成人精神分裂症患者使用布南色林的人群药代动力学研究
Daisuke Nemoto,Takeshi Takagaki,Atsushi Kitamura et al.
Daisuke Nemoto et al.
The second-generation antipsychotic blonanserin is a highly selective, full antagonist of dopamine D2 and D3 and serotonin 5-HT2A receptors. It is currently prescribed for patients with schizophrenia in Japan. We aimed to develop a populati...
Population pharmacokinetic and exposure-response analysis to support a dosing regimen of CPX-351 (NS-87) in Japanese adult and pediatric patients with untreated high-risk acute myeloid leukemia [0.03%]
支持CPX-351（NS-87）在日本成人及儿童高危急性髓系白血病初治患者中给药方案的群体药代动力学和暴露-效应关系分析
Shunji Imai,Ayane Kitada,Aya Ogura et al.
Shunji Imai et al.
CPX-351 (NS-87; Vyxeos®) has a characteristic liposomal formulation and contains cytarabine and daunorubicin at a 5:1 molar ratio, which demonstrates synergistic activity in both in vitro and in vivo animal models. It has been approved in ...
Effect of obesity on pharmacokinetics of transdermal fentanyl: Single-center retrospective study and animal study [0.03%]
肥胖对透皮芬太尼药动学影响的单中心回顾性研究与动物实验研究
Satoshi Mizuno,Shintaro Gake,Makiko Takabayashi et al.
Satoshi Mizuno et al.
A retrospective study and an animal study were conducted to investigate factors affecting the transdermal fentanyl dose to achieve adequate pain relief in patients switched from other opioids. In the retrospective study, patient factors wer...
Vincenzo Paolillo,Mahendran Jayakumar,Colton Sheperd et al.
Vincenzo Paolillo et al.
Areca nut (AN) is a substance of abuse consumed by millions worldwide, in spite of established oral and systemic toxicities associated with its use. Previous research demonstrates methyl ester alkaloids in the AN, such as arecoline and guva...