Drug interaction studies on new drug applications: current situations and regulatory views in Japan [0.03%]
日本新药申请中的药物相互作用研究及其监管看法
Naomi Nagai
Naomi Nagai
Drug interaction studies on new drug applications (NDAs) for new molecular entities (NMEs) approved in Japan between 1997 and 2008 are examined in the Pharmaceuticals and Medical Devices Agency (PMDA). The situations of drug interaction stu...
Update on prediction of drug metabolizing enzyme- and transporter-based drug interactions [0.03%]
基于代谢酶和转运体的药物相互作用预测研究进展
Kiyomi Ito,Miki Nakajima
Kiyomi Ito
Genetic polymorphisms of copper- and platinum drug-efflux transporters ATP7A and ATP7B in Japanese cancer patients [0.03%]
日本癌症患者铜和铂类药物外排转运蛋白ATP7A和ATP7B的基因多态性
Hiromi Fukushima-Uesaka,Yoshiro Saito,Keiko Maekawa et al.
Hiromi Fukushima-Uesaka et al.
ATP7A and ATP7B are involved in cellular resistance to platinum compounds such as cisplatin. By sequencing ATP7A, 38 genetic variations, including 30 novel ones were detected from 203 Japanese cancer patients. Of these, seven nonsynonymous ...
Genetic variations in the HGPRT, ITPA, IMPDH1, IMPDH2, and GMPS genes in Japanese individuals [0.03%]
日本人体内HGPRT、ITPA、IMPDH1、IMPDH2和GMPS基因的遗传变异
Mutsumi Kudo,Yuka Saito,Takamitsu Sasaki et al.
Mutsumi Kudo et al.
Thiopurines (such as azathioprine and 6-mercaptopurine) are widely used for the treatment of patients suffering from malignancies, rheumatic disease, inflammatory bowel disease and solid organ transplant rejection. These drugs are activated...
Ethnic differences of two non-synonymous single nucleotide polymorphisms in CDA gene [0.03%]
CDA基因两个非同义单核苷酸多态性的民族差异分析
Emiko Sugiyama,Su-Jun Lee,Sang Seop Lee et al.
Emiko Sugiyama et al.
Cytidine deaminase, encoded by the CDA gene, catalyzes anti-cancer drugs gemcitabine and ara-C into their respective inactive metabolites. In CDA, two functionally significant non-synonymous polymorphisms, 79A>C (Lys27Gln) and 208G>A (Ala70...
Bonitos with low content of malodorous trimethylamine as palliative care for self-reported Japanese trimethylaminuria subjects [0.03%]
提高品质的马鲛鱼作为日本自发性三甲胺尿症患者的辅助疗法
Makiko Shimizu,Marie Kozono,Norie Murayama et al.
Makiko Shimizu et al.
Trimethylaminuria is caused by excessive malodorous trimethylamine excreted via urine and body secretion by decreased hepatic flavin-containing monooxygenase 3 (FMO3) metabolic capacity for transforming non-odorous trimethylamine N-oxide. T...
Influence of the genetic polymorphisms in the 5' flanking and exonic regions of CYP2C19 on proguanil oxidation [0.03%]
CYP2C19基因5’启动子和外显子多态性与普鲁甘啶氧化的关系
Chakradhara Rao Uppugunduri Satyanarayana,Anichavezhi Devendran,Muthukumaran Jayaraman et al.
Chakradhara Rao Uppugunduri Satyanarayana et al.
CYP2C19 is a polymorphic enzyme which metabolizes several clinically important drugs including proguanil. Variation in the 5' regulatory region may influence CYP2C19 activity. This study evaluates the relationship between proguanil metaboli...
mRNA expression of MDR1 and major metabolising enzymes in human fetal tissues [0.03%]
人胎盘组织中MDR1及主要代谢酶的基因表达研究
May Fakhoury,Tiphaine de Beaumais,Fabien Guimiot et al.
May Fakhoury et al.
Metabolising enzymes and transport proteins are largely expressed in human tissues. They have major impact on drug disposition and effects. We studied mRNA expression of phase I and II metabolising enzymes and transporters in fetal tissues ...
Identification of human UDP-glucuronosyltransferase isoforms responsible for the glucuronidation of glycyrrhetinic acid [0.03%]
甘草酸葡糖醛酸化的负责的人体UDP-葡萄糖醛酸转移酶同工酶的鉴定
Yang Lu,Jing Zhu,Xijing Chen et al.
Yang Lu et al.
Glycyrrhetinic acid, the active metabolite of glycyrrhizin, is primarily eliminated by glucuronidation reaction in vivo. In spite of the widespread clinical use of glycyrrhizin, UDP-glucuronosyltransferase (UGT) isoforms involved in the glu...
Biotransformation profiling of [(14)C]ixabepilone in human plasma, urine and feces samples using accelerator mass spectrometry (AMS) [0.03%]
采用加速器质谱法测定依喜替康在人血浆、尿和粪便中的生物转化谱分布研究
S Nilgün Cömezoğlu,Van T Ly,Donglu Zhang et al.
S Nilgün Cömezoğlu et al.
Ixabepilone (BMS-247550, Ixempra is a semi-synthetic analog of the natural product epothilone B and marketed for its use in the treatment of cancer. A conventional human ADME study using decay counting methods for (14)C detection could not ...