Results of a Phase 1 Open-Label, Dose-Escalation Study of Gene Therapy With AAV2-hAQP1 for Grade 2 and 3 Radiation-Induced Late Xerostomia and Parotid Gland Hypofunction [0.03%]
AAV2-hAQP1基因疗法治疗2级和3级放射性口干症和腮腺功能减退I期开放标签剂量递增研究结果
Michael T Brennan,Michael J Passineau,Deborah Saunders et al.
Michael T Brennan et al.
Purpose: Grade 2 and 3 late xerostomia is a chronic, debilitating complication of radiation therapy for head and neck cancers. We assessed the safety and efficacy of AAV2-hAQP1 gene therapy as a treatment for this conditi...
Radiation Quality and Workflow in NRG GY017: Anti PD-L1 (Atezolizumab) as an immune primer or concurrently with RT for node positive locally advanced cervical cancer [0.03%]
NRG GY017放疗质子与免疫治疗（阿特朱单抗）的流程和质量控制：在淋巴结阳性的局部晚期宫颈癌患者中使用抗PD-L1 (阿特朱单抗)进行免疫启动或同步放化疗
Jyoti Mayadev,Wei Deng,Hayeon Kim et al.
Jyoti Mayadev et al.
Objectives: Advances in radiation (RT) treatment planning enhance the need for uniform quality oversight on clinical trials. NRG GY-017 was a randomized trial of the anti PD-L1 antibody, atezolizumab, before and concurren...
Defining the Role of SABR in Head and Neck Cancer: Results from a Multi-institutional Delphi Consensus [0.03%]
SABR在头颈癌中作用的定义：一项多中心共识调查的结果
Claire Petit,Jack Phan,Sweet Ping Ng et al.
Claire Petit et al.
Background: The role of stereotactic ablative radiotherapy (SABR) in head and neck cancer remains uncertain. Historically used mainly for re-irradiation, its application in other clinical scenarios has expanded with recen...
Proton beam therapy for large localized hepatocellular carcinomas in western patients [0.03%]
西方患者的大型局限性原发性肝细胞癌的质子治疗
Kanokphorn Thonglert,Matthew D Greer,Stephanie K Schaub et al.
Kanokphorn Thonglert et al.
Purpose/objectives: Optimal management of large, unresectable hepatocellular carcinoma (HCC) remains uncertain. Proton beam therapy (PBT) offers dosimetric advantages for sparing normal liver. Clinical outcomes for these ...
Radiation dose-dependent skin toxicity and therapeutic advantage of FLASH radiotherapy via immune modulation [0.03%]
剂量依赖性皮肤放射毒性及FLASH放疗通过免疫调节获得治疗优势
Salomé Paillas,Chee Kin Then,Alejandro Suárez-Bonnet et al.
Salomé Paillas et al.
Background: FLASH radiotherapy shows promise in reducing normal tissue toxicity compared to conventional radiotherapy. Although several studies report skin-sparing effects of FLASH, few have quantitatively assessed this e...
Elective Nodal Radiotherapy in Localized Prostate Cancer: A Meta-Analysis [0.03%]
局限性前列腺癌选择性淋巴结放疗的meta分析
Soumyajit Roy,Angela Y Jia,Nicholas G Zaorsky et al.
Soumyajit Roy et al.
Purpose: Recently, results from NRG/RTOG 0924, the largest randomized trial to evaluate the benefit of whole-pelvic radiotherapy (WPRT) in localized prostate cancer, were presented. We conducted an aggregate meta-analysis...
Longitudinal Plasma Proteomics Reveals an Immuno-thrombotic Signature that Predicts Radiation Pneumonitis in Lung Cancer [0.03%]
纵向血浆蛋白质组学揭示了预测肺癌放射性肺炎的免疫-血栓特征
Wu Lingyun,Masaki Nakamura,Mukohara Toru et al.
Wu Lingyun et al.
Purpose: Radiation pneumonitis (RP) is a dose-limiting toxicity in lung cancer radiotherapy, often poorly predicted by static clinical and dosimetric models. We aimed to identify a robust, blood-based proteomic signature ...
Long-term outcomes after proton therapy vs. intensity-modulated photon radiotherapy with concurrent chemotherapy for locally advanced non-small-cell lung cancer: post-hoc analysis of a prospective randomized trial [0.03%]
前瞻性随机试验的事后分析：局部晚期非小细胞肺癌患者质子治疗和同期化疗的长期结局与调强光子放疗的对比研究
Tingshi Su,Ting Xu,Mei Chen et al.
Tingshi Su et al.
Purpose: To report long-term toxicity and disease outcomes from a randomized trial comparing passive-scattering proton therapy (PSPT) and intensity-modulated photon radiotherapy (IMRT), both with concurrent chemotherapy, ...
Radiotherapy de-escalation in breast cancer patients with pathologic complete response: An integrated analysis using real-world and simulated data [0.03%]
乳腺癌病理完全缓解患者放射治疗减量化：真实世界与模拟数据的综合分析
Jian Wang,Jing Ning,Simona F Shaitelman et al.
Jian Wang et al.
Background: Advances in neoadjuvant chemotherapy (NAC) have markedly increased pathologic complete response (pCR) rates in breast cancer, prompting reevaluation of the need for adjuvant radiotherapy (RT) in patients with ...
External Beam Radiotherapy (EBRT) & Immunotherapy (IO) in the Management of Hepatobiliary Malignancies: A Meta-analysis of Treatment Response Rates [0.03%]
外照射放射治疗（EBRT）与免疫检查点抑制剂在肝胆恶性肿瘤综合治疗中疗效的荟萃分析研究：一项系统评价和Meta分析研究
J J Juarez Vignon Whaley,M L Peters,M J Abrams
J J Juarez Vignon Whaley
Purpose: To evaluate in a meta-analysis the efficacy of external beam radiotherapy (EBRT) with immunotherapy (IO) in hepatobiliary malignancies, including hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), and i...