Jararaca GPIb-binding protein from Bothrops jararaca snake venom induces intense thrombocytopenia in mice [0.03%]
Bothrops jararaca毒蛇 venom中的 Jararaca GPIb结合蛋白可诱发小鼠严重血小板减少症
Adrielly Viveiros Torres,Natacha Ferreira de Oliveira,Eduardo Oliveira Venancio de Lima et al.
Adrielly Viveiros Torres et al.
Snakes of the genus Bothrops are responsible for most snakebites in Latin America, frequently associated with hemostatic disorders. Among venom components, C-type lectin-like proteins (CTLPs) stand out for their ability to interact with pla...
Computational modelling the impact of GLP-1 receptor agonists on botulinum toxin A: Evidence for reduced treatment durability across neurologic and aesthetic indications [0.03%]
计算GLP-1受体激动剂对肉毒杆菌毒素A影响的模型：证据表明其会降低治疗持久性（神经学和美容应用）
Eqram Rahman,Alain Michon,Parinitha Rao et al.
Eqram Rahman et al.
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have transformed metabolic and aesthetic medicine, yet their potential influence on botulinum toxin type A (BoNT-A) pharmacodynamics remains unexplored. Using the AesthetiSIM™ microsimu...
Edgar Neri-Castro
Edgar Neri-Castro
Despite Mexico's unique diversity of venomous snakes, the neurotoxic components of their venoms have remained understudied. Fifteen years ago, no formal records existed of neurotoxic viper species in the country, and while Mexican elapids w...
Unveiling the Inflammatory Response in Macrophages Induced by Micrurus lemniscatus Venom [0.03%]
秘鲁树锦蛇毒液诱导的巨噬细胞炎症反应研究
Sulamita da S Setúbal,Larissa Faustina Cruz,Valdison P Dos Reis et al.
Sulamita da S Setúbal et al.
The coral snakes (Micrurus, Elapidae) are an important etiologic agent of snakebites in Brazil. While envenomation is usually associated with neurotoxic effects, numerous experimental studies have shown that Micrurus venom can also cause in...
Dual Substrate Catalytic Detoxification of Aflatoxin B1 and Zearalenone by a Novel Enzyme PsCopA from Pseudomonas for Food and Feed Safety [0.03%]
来源于假单胞菌的PsCopA酶对食品和饲料中黄曲霉毒素B1和玉米赤霉烯酮的联合催化解毒作用
Ranran Ma,Fred Mwabulili,Weiwei Peng et al.
Ranran Ma et al.
Fungal mycotoxins pose a serious threat to human and animal health, especially due to their co-occurrence in food and feed, causing synergistic toxicity. Current enzymatic detoxification strategies often depend on redox mediators, limiting ...
Ustiloxins induce kidney injury via the TLR2/MAPK/NF-κB pathway [0.03%]
通过TLR2 / MAPK / NF-κB途径诱导肾脏损伤的USTILOXINS
Yingchun Du,Guomei Zhang,Xuming Zhou et al.
Yingchun Du et al.
Ustiloxins levels are associated with abnormal renal function indicators, suggesting that ustiloxins may be risk factors for kidney damage. Given limited evidence on the underlying mechanisms, this study investigated the mechanisms linking ...
Molecular Monitoring, Identification of the Microcystin Synthetase (mcy) Gene and Toxic Potential of Microcystis aeruginosa in Indian Freshwater Blooms [0.03%]
印度淡水水华中微囊藻分子检测、合成酶（mcy）基因的鉴定及其毒性潜势
Priyanka Jayam Rajendran,Sumathy Shunmugam,Chandraleka Saravanan et al.
Priyanka Jayam Rajendran et al.
Toxicological assessment and DNA-based microcystin synthetase gene identification were used to examine the occurrence, distribution, and toxicity of cyanobacteria from 30 freshwater bloom samples, India. Microcystis aeruginosa was the most ...
Anabaenopeptin-A, anabaenopeptin-B, aeruginosin-98B, their binary and ternary mixtures alter biochemical biomarkers, tyrosine phosphatase and HSP70 heat shock protein of Daphnia magna [0.03%]
安氨肽素-A、安氨肽素-B和98B藻毒素，及其二元或三元混合物可改变水蚤(Daphniamaiga)的生化生物标志物、酪氨酸磷酸酶和HSP70热休克蛋白
Adam Bownik,Barbara Pawlik-Skowrońska
Adam Bownik
The aim of the present study was to assess the effects of three cyanobacterial metabolites anabaenopeptin-A (ANA-A), anabaenopeptin-B (ANA-B) and aeruginosin-B (AER-B) on biochemical responses: hemoglobin and total nitric oxide (NO) levels,...
Complying with ARRIVE 2.0: Reporting essentials for animal models of envenoming therapeutic efficacy testing [0.03%]
遵循ARRIVE 2.0：动物毒液模型中验证疗法有效性的实验报告要点
Amy E Marriott,Stuart Ainsworth
Amy E Marriott
Preclinical murine models remain the primary method for assessing the efficacy of antivenoms, yet the quality and transparency of reporting in these studies is often varied and inconsistent. This undermines reproducibility, limits the poten...
Should snakes used in antivenom production be retired? An analysis of Bothrops moojeni venom at different ages [0.03%]
毒蛇使用于抗蛇毒血清生产中的年限问题——以莫仁锯鳞蛇为例分析不同年龄个体的毒素差异
M I Moitas,G M Reis,E O V Lima et al.
M I Moitas et al.
Accidents involving venomous snakes in Brazil are mostly caused by the Bothrops genus. Snake venoms, just like Bothrops moojeni venom, one of the snake species used to produce the antibotropic serum, may have variations in its venom due to ...