Mitochondrial epigenetic remodeling and integrated stress response induced by Microcystin-LR: Experimental evidence and preliminary PP2A structural targeting [0.03%]
微囊藻毒素LR诱导的线粒体表观遗传重编程和整合应激反应：实验依据及PP2A结构靶向研究初步
Nikita Soni,Apoorva Chouksey,Vikas Gurjar et al.
Nikita Soni et al.
MC-LR, a potent cyanotoxin produced by specific kinds of cyanobacteria, is widely acknowledged for its cytotoxic effects; however, its role in mitochondrial-mediated epigenetic regulation remains poorly characterized. This study examined th...
Patentability of natural products from Venomous Organisms: A guide for life science researchers [0.03%]
毒液生物中天然产物的专利性：生命科学领域研究者的指南
Maria P Ikonomopoulou,Gregor Anderluh,Sahin Coskun et al.
Maria P Ikonomopoulou et al.
This report is built on insights gathered during the European Venom Network (EUVEN) workshop on the patentability of natural compounds, with a particular focus on venom-derived molecules, held online on June 10, 2022. The program explored k...
Venoms and toxins that induce anticoagulation in vitro do not cause major alterations in coagulation parameters in vivo in a mouse model [0.03%]
一种模型中体内实验所用的使凝血参数产生较大变化的毒液及毒素在体外实验中并不诱导抗凝血作用
Erika Camacho,Gabriel Ramírez-Vargas,Karol Vargas et al.
Erika Camacho et al.
Snake venoms exert profound effects on blood coagulation, mostly associated with consumption coagulopathy due to the procoagulant activity of venom proteinases, which result in drastic alterations of laboratory clotting tests. In addition, ...
Isolation, characterization, and peptide synthesis of fragments from the first phospholipase A2 identified in Rhinella diptycha toad poison [0.03%]
从Rhinella diptycha毒液中鉴定并表征的第一种磷脂酶A2的分离、定性和肽合成
Elisa Naomi Suzuki de Andrade Loureiro,Francielle Almeida Cordeiro,Gisele Adriano Wiezel et al.
Elisa Naomi Suzuki de Andrade Loureiro et al.
Toad poison is composed of a range of molecules, such as alkaloids, bufotoxin, proteins, and peptides, including phospholipases A2 (PLA2). PLA2s are responsible for catalyzing the hydrolysis of the ester bonds of phospholipids, which are on...
Snake Venom Meets Oncology: Unraveling the Anticancer Potential of Crotamine [0.03%]
蛇毒与肿瘤学碰撞：解码crotoxin的抗癌潜力
Beatriz Jacob,João Alberghini-Dos-Santos,Isabela Ferreira et al.
Beatriz Jacob et al.
Cancer remains a significant global health challenge, prompting the search for novel therapeutic strategies that minimize the limitations of current treatments. Crotamine, a cationic myotoxin isolated from the venom of Crotalus durissus spp...
Two-year real-world retrospective safety evaluation with onabotulinumtoxinA across multiple therapeutic indications: findings from the SYNCHRONIZE study [0.03%]
一种肉毒杆菌毒素A两年期真实世界回顾性安全评估：多项治疗适应证的同步研究结果分析
Grace Forde,Kimberly Becker Ifantides,Angeli Mayadev et al.
Grace Forde et al.
OnabotulinumtoxinA (onabotA) is approved for the treatment of various therapeutic indications, which require retreatment. In clinical practice, many patients receive onabotA for multiple therapeutic indications concomitantly over extended t...
Contaminants in organic products: 26-year analysis of EU RASFF notifications [0.03%]
欧盟RASFF通报的有机产品污染物26年分析
Fawzy Eissa,Mahmoud Al-Sisi,Osama Elhamalawy et al.
Fawzy Eissa et al.
This study analyzes 26 years of European Union Rapid Alert System for Food and Feed (RASFF) notifications concerning mycotoxins (354 notifications), pathogenic microorganisms (311), and pesticide residues (300) in organic products from 1999...
Effects of cyanobacterial oligopeptides: microginin-FR1, anabaenopeptin-B, aeruginosins 98A and 98B on caspase 3/7, HSP70, cAMP and tyrosine phosphatase activity in RTgill-W1 cells [0.03%]
微藻寡肽：微囊素-FR1，安美阿普丁-B，类红球菌素98A和98B对RTgill-W1细胞中半胱天冬酶3/7、HSP70、cAMP及酪氨酸磷酸酶活性的影响
Adam Bownik,Barbara Pawlik-Skowrońska
Adam Bownik
We aimed to determine the effects of linear cyanobacterial oligopeptides: microginin-FR1 (MG-FR1), anabaenopeptin-B (ANA-B), aeruginosin 98A (AER-A), aeruginosin 98B (AER-B) and their binary and quaternary mixtures on RTgill-W1 cell line. T...
Bioactivity profiling of spider venoms reveals predominant hyaluronidase activities [0.03%]
蜘蛛毒液的生物活性谱分析发现透明质酸酶是其主要功能蛋白质
Josephine Dresler,Volker Herzig,Lennart Schulte et al.
Josephine Dresler et al.
Spider venoms are primarily composed of small neurotoxic peptides. However, recent studies suggested a hitherto overlooked diversity of spider venom enzymes, although their functional space still remains largely unexplored. We tested 10 spi...
Computational model-informed comparative evaluation of botulinum toxin a formulations: A 20-year simulation of onset, diffusion, duration, and immunogenicity [0.03%]
肉毒杆菌毒素A配方的计算模型信息比较评估：起效、弥散、持续时间和免疫原性的20年模拟
Eqram Rahman,Alain Michon,Parinitha Rao et al.
Eqram Rahman et al.
Comparative evaluation of botulinum neurotoxin type A (BoNT/A) formulations is limited by short clinical trials and lack of long-term safety data. This study applied a validated multiscale computational model (AesthetiSIM™) to simulate 20 ...