Oncolytic Viral Therapy under Type I Interferon Regulation: Mathematical Modeling and Analysis [0.03%]
一类干扰素调节下的溶瘤病毒疗法的数学建模与分析
Prathibha Ambegoda,Hsiu-Chuan Wei,Sophia R-J Jang
Prathibha Ambegoda
We present and analyze a delay differential equation model of oncolytic viral therapy (OVT) that incorporates tumor-immune-virus interactions, type I interferon (IFN-I) dynamics, and a discrete time delay representing the viral infection cy...
A stochastic reaction-diffusion HIV/AIDS model with implications for long-Acting ART [0.03%]
具有长效抗逆转录病毒疗法意义的随机反应扩散HIV/AIDS模型
Baozhou Gao,Yantao Luo,Long Zhang et al.
Baozhou Gao et al.
This study proposes a stochastic reaction-diffusion model for HIV/AIDS transmission to uncover the foundational mechanisms behind disease extinction and project the future trajectory of the pandemic. For the proposed model, we initially app...
Dynamical analysis of a spatially heterogeneous disease model with degenerate structure [0.03%]
具退化迁徙结构的时空传染病模型的动力学分析
Yuwei Feng,Jinliang Wang,Yixiang Wu
Yuwei Feng
This study analyzes a reaction-diffusion model for cocoa black pod disease (CBPD) with space-dependent parameters and partial degeneracy, which assumes that susceptible and infected cocoa pods remain immobile within the region. Spores produ...
Persistence for a class of nonautonomous systems of differential equations with unbounded delays [0.03%]
具有无界时滞的一类非自治微分方程的持久性
Teresa Faria,José J Oliveira
Teresa Faria
For a family of nonautonomous systems of differential equations with unbounded delays, sufficient conditions for their persistence are established. In general, these systems are non-cooperative, so the usual techniques for monotone systems ...
Sensitivity and uncertainty analyses for model of olfaction using Dempster-Shafer theory and neural networks [0.03%]
基于 Dempster-Shafer 理论和神经网络的嗅觉模型的敏感性和不确定性分析
Y He,L Waldrop
Y He
Olfactory systems in arthropods rely on arrays of chemosensory hairs (sensilla) that interact with the surrounding fluid to capture odor cues. The fluid dynamics depend on both morphological parameters and flow conditions, and variability i...
Stability and bifurcation of Mpox transmission model with population heterogeneity and booster vaccination [0.03%]
考虑人群异质性和加强免疫的猴痘传播模型的稳定性及分岔分析
Xiong Lei,Xin-You Meng,Jiao-Guo Wang
Xiong Lei
In this paper, we consider a novel mpox virus transmission model with human interactions, hospitalization rates, vaccination coverage (single-dose and two-dose), and vaccine efficacy, where the susceptible individuals are divided into low-r...
Combining model-based and data-driven models: an application to synthetic biology resource competition [0.03%]
模型与数据驱动模型的结合——合成生物学中的资源竞争分析案例研究
Atefe Darabi,Zheming An,Muhammad Ali Al-Radhawi et al.
Atefe Darabi et al.
This work explores the integration of machine learning (ML) and mechanistic models (MM). While ML has demonstrated remarkable success in data-driven modeling across engineering, biology, and other scientific fields, MM remain essential for ...
The impact of migration-mediated multi-threshold control strategies on disease spread of a Filippov patch epidemic model [0.03%]
迁移介导的多阈值控制策略对Filippov补丁传染病模型疾病传播的影响
Cunjuan Dong,Long Zhang,Zhidong Teng
Cunjuan Dong
In this paper, a two-patch epidemic model incorporating migration-mediated multi-threshold control strategies is proposed to explore the effect of migration and adaptive interventions (e.g, lockdown) on disease transmission. If the numbers ...
Tumor growth and immune response: on the impact of the space-structuration of the tumor microenvironment [0.03%]
肿瘤生长与免疫反应：肿瘤微环境空间结构化的影响
Christian Tayou Fotso,Fabienne Anjuère,Véronique M Braud et al.
Christian Tayou Fotso et al.
We use a model inspired from mixture theory to describe tumor growth, its interaction with the environment, its needs of nutrients and oxygen supply, and the effects of the immune response. The latter might have a dual nature, since the exp...
Wangyang Wu,Shumin Tan,Moxun Tang et al.
Wangyang Wu et al.
We study periodic gene transcription in a tandem gene system, where an external periodic signal modulates the expression of an upstream gene, whose products subsequently regulate the expression of a downstream gene. For the external signal ...