N-terminal domains and site-specific glycosylation regulate the secretion of avian melanocortin inverse agonists, agouti signaling protein (ASIP) and agouti-related protein (AGRP) [0.03%]
N端结构域和特异性糖基化调节禽类黑皮质素受体拮抗剂(如ASIP和AGRPR蛋白)的分泌作用
Hibiki Fukuchi,Ryoya Watanabe,Yuna Iida et al.
Hibiki Fukuchi et al.
Agouti signaling protein (ASIP) and agouti-related protein (AGRP) are paralogous inverse agonists of melanocortin receptors with distinct physiological roles, but their structural and biochemical properties in birds remain poorly understood...
Dietary genistein mitigated arsenic-induced growth inhibition, oxidative stress, inflammation, apoptosis, disruption of tight junction proteins, and intestinal histomorphological damage in Nile tilapia [0.03%]
饮食性大豆异黄酮缓解了砷引起的尼罗罗非鱼生长抑制、氧化应激、炎症、凋亡、紧密连接蛋白紊乱和肠组织形态损害
Badriyah S Alotaibi,Amany Abdel-Rahman Mohamed,Saed A Althobaiti et al.
Badriyah S Alotaibi et al.
Arsenic is a widespread trace element that adversely affects fish health and growth. This study investigated the potential of a genistein-fortified diet (500 mg/kg) to mitigate effects of arsenic exposure in Oreochromis niloticus. The 60-d ...
Taurine in Ruditapes philippinarum: tissue distribution, developmental dynamics and metabolic mechanism [0.03%]
菲律宾贻贝（褶纹冠蚌）中的牛磺酸：组织分布、发育动态及代谢机制
Yang Liu,Kai Liao,Yang Zhang et al.
Yang Liu et al.
Bivalves, although often overlooked as a source of taurine in the diet, have tissue levels of taurine that are notably higher than those in most vertebrates. However, the handling and metabolism of taurine in bivalves is still poorly unders...
Delta/notch signaling regulates blastema formation during limb regeneration in Eriocheir sinensis [0.03%]
秀丽隐杆线虫肢体再生过程中Delta/Notch信号调节芽体形成
Hao Li,Weijia Liu,Lei Zhu et al.
Hao Li et al.
Limb autotomy and regeneration represent specialized adaptive responses employed by crustaceans to cope with threats from other animals or environmental stress. However, the molecular regulatory mechanisms underlying these adaptations remai...
Myomaker is regulated by miR-489 and miR-24-3p, and controls fusion of myoblasts in the gynogenetic blunt snout bream [0.03%]
miR-489和miR-24-3p通过调节肌节蛋白myomaker控制锯盖鱼渐变态过程中肌细胞融合
Siyao Weng,Mingguang Hu,Wangwang Ji et al.
Siyao Weng et al.
The fusion process of myoblasts constitutes a critical phase in skeletal muscle myogenesis. The recently identified transmembrane protein Myomaker, which is muscle-specific, plays an indispensable role in myoblast fusion. However, the regul...
Combined physiological effects of high temperature and salinity stress on genetically improved farmed tilapia (Oreochromis niloticus) reared in inland saline water [0.03%]
高溫鹽度復合胁迫对尼罗罗非鱼遗传改良品系生理的综合影响
Shivangi Bhatt,N P Sahu,Subodh Gupta et al.
Shivangi Bhatt et al.
Freshwater scarcity and increasing salinisation of inland water bodies pose significant challenges to aquaculture. Using inland saline water (ISW) for aquaculture offers a promising option to expand farming into salt-affected and non-arable...
Transcriptomic analysis of the comprehensive immune responses induced by recombinant interferon γ and characterization of antiviral Mx2 protein in black rockfish Sebastes schlegelii [0.03%]
黑斑侧带鱼重组干扰素γ诱导的全面免疫应答转录组分析及抗病毒蛋白Mx2特征研究
Hao Jing,Kai Yang,Yue Wang et al.
Hao Jing et al.
Interferon-gamma (IFNγ) is a key immune regulator in teleost fish, yet its mechanisms of action remain poorly understood. In this study, we investigated the immunomodulatory role of recombinant Sebastes schlegelii IFNγ (rSsIFNγ) in intes...
Effects of salinity on the regulation of long-chain polyunsaturated fatty acid biosynthesis in the polychaete Platynereis dumerilii [0.03%]
盐度对环节动物Platynereis dumerilii长链多不饱和脂肪酸生物合成调控的影响机制研究
Khalida Bainour,Óscar Monroig,Marc Ramos-Llorens et al.
Khalida Bainour et al.
Polychaetes are promising sources of n-3 long-chain (≥C20) polyunsaturated fatty acid (LC-PUFA) due to their ability to synthesise these essential nutrients through elongases, front-end desaturases (Fed), and methyl-end desaturases. Salini...
Transcriptional and epigenetic responses to acute hypoxia exposure in rainbow trout (Oncorhynchus mykiss) [0.03%]
虹彩 trout(Oncorhynchus mykiss)应对急性缺氧暴露的转录和表观遗传反应
William Johnston,Sally Adil,Jan A Mennigen
William Johnston
Rainbow trout, which are comparatively intolerant to low oxygen, face increasing hypoxic events. This study investigated their metabolic and molecular responses to acute hypoxia and investigated whether O2-dependent epigenetic marks mediate...
Dietary thiamine supplementation enhances the growth performance, digestive enzyme activity, intestine development, immunity and anti-inflammatory gene expression of juvenile olive flounder (Paralichthys olivaceus) [0.03%]
硫胺素补充对皱壳扁虾虎鱼（Paralichthys olivaceus）生长性能、消化酶活性、肠道发育、免疫及抗炎基因表达的影响
Yeonji Lee,Suhyeok Kim,Mirasha Hasanthi et al.
Yeonji Lee et al.
This research aimed to determine the dietary requirement of thiamine and evaluate its effects on olive flounder (Paralichthys olivaceus). Control diet (Con) was formulated without thiamine supplementation, while four additional diets were f...