Pregnancy-induced mechanisms regulating central and peripheral leptin sensitivity: lessons from sheep [0.03%]
妊娠诱发的调控中枢和外周瘦素敏感性的机制——来自羊的启示
Malgorzata Szczesna,Katarzyna Kirsz,Dorota A Zieba
Malgorzata Szczesna
This review describes various aspects of the leptin resistance phenomenon and related physiological mechanisms that occur in pregnant sheep. Its main aim is to analyze the mechanisms that determine the occurrence of pregnancy-induced leptin...
Active immunization with a novel recombinant GnRH vaccine inhibits reproductive function in male goats [0.03%]
新型促性腺激素释放激素重组疫苗的主动免疫抑制公山羊的生殖功能
Moyan Di,Xinbao Gong,Yanyun Zhu et al.
Moyan Di et al.
Gonadotropin-releasing hormone (GnRH) vaccines have been widely used to effectively inhibit gonadal development and reproductive function. To improve the immunogenicity of GnRH, we developed and evaluated the effects of GnRH6-kisspeptin-CRM...
Poor maternal nutrition during gestation in sheep alters key hormonal systems involved in energy homeostasis and appetite in the offspring [0.03%]
母羊怀孕期间营养不良影响后代体内关键激素系统及摄食行为
Nicole M Tillquist,Kristen E Govoni,Steven A Zinn et al.
Nicole M Tillquist et al.
Disturbances in maternal nutrient availability through increased or decreased abundance of specific or total nutrients during pre-natal development can have negative impacts on offspring growth. These changes are likely mediated, at least i...
17β-estradiol inhibits lipopolysaccharide-induced inflammation and pyroptosis of Leydig cells of the domestic yak (Bos grunniens) via the SIRT1/Nox4/ROS pathway [0.03%]
雌二醇通过SIRT1/Nox4/ROS信号途径抑制牦牛(Leydig细胞的脂多糖诱导的炎症和焦亡反应
Junyuan Ma,Yanmei Yang,Lin He et al.
Junyuan Ma et al.
Estradiol (E2) secreted by Leydig cells (LCs) can accumulate in the testes due to constriction of the reproductive lumen. Estrogen is not only important for reproduction, but also protects against inflammation. In this study, the role of py...
Correlation of Anti-Müllerian hormone serum concentration measured in proestrus and estrus with the litter size as a fertility marker in bitches [0.03%]
抗穆勒管激素血清浓度与母狗生育力标志物及胎仔数量的相关性研究
Theresa Hornberger,Sven Reese,Klaus Perbandt et al.
Theresa Hornberger et al.
The use of the anti-Müllerian hormone (AMH) serum concentration as a fertility marker has been shown in cows, sheep and mares and has been indicated in one study in female dogs. The aim of this study was to investigate the connection betwe...
Evaluation of serum insulin-like growth factor 1 concentrations in non-diabetic cats with chronic kidney disease [0.03%]
评估非糖尿病慢性肾脏病猫血清胰岛素样生长因子1浓度
J P Rey Amunategui,E M Molina,G A Pompili et al.
J P Rey Amunategui et al.
Feline hypersomatotropism (HST) can develop in both diabetic and non-diabetic cats, but studies evaluating the prevalence of HST in cats without diabetes mellitus (DM) are lacking. The aims of the study were to evaluate circulating insulin-...
The structure of the porcine uterine-conceptus interface is associated with gestational day, fetal size and sex [0.03%]
妊娠天数、胎儿大小和性别与猪子宫-概念株接口结构相关性研究
Tailine Rayane Lima Reis,João Vitor Lopes-Ferreira,Karen Beatriz Guerra et al.
Tailine Rayane Lima Reis et al.
This study aimed to characterize histological changes of the maternal-conceptus interface in feto-placental units associated with fetal weight and sex throughout pregnancy. Pregnant Large-White X Landrace gilts(n=18) were euthanized and hys...
Distribution and sequence analysis of the melanocortin 2 receptor in horses and ponies [0.03%]
马和矮马的促黑激素2受体的分布及序列分析
Christina M Cash,Melody A de Laat
Christina M Cash
The melanocortin 2 receptor (MC2R) has relevance to equine pituitary pars intermedia dysfunction (PPID), as it is the primary binding site for ACTH, which circulates at elevated concentrations in animals affected by PPID. Despite this, litt...
Short-term clinical and biochemical responses following treatment with dapagliflozin or ertugliflozin in horses with hyperinsulinemia: A retrospective case series [0.03%]
回顾性病例系列研究马匹高胰岛素血症接受达格列净或特哥列净治疗后的短期临床和生化反应
Tania Sundra,Edd Knowles,David Rendle et al.
Tania Sundra et al.
The metabolic and lipid profiles of horses treated with sodium-glucose cotransporter 2 inhibitors are not well understood. This retrospective study evaluated blood parameters in hyperinsulinemic horses treated with either ertugliflozin (0.0...
F Frers,J Delarocque,K Feige et al.
F Frers et al.
The underlying molecular mechanisms leading to insulin dysregulation are poorly understood in horses. Therefore, this study aimed to determine if insulin dysregulation is associated with an altered basal expression and extent of phosphoryla...