Opioid and α2-adrenoceptors interaction on the lethality, antinociception, antinociceptive tolerance, and precipitated withdrawal in mice treated with fentanyl and xylazine [0.03%]
阿片受体和α_2肾上腺素受体对喷他佐辛和氯胺酮致小鼠死亡、镇痛、镇痛耐受及戒断反应的影响
Damaris Albores-García,Silvia L Cruz
Damaris Albores-García
Background: Xylazine, an α2-adrenoceptor agonist approved for veterinary use, has increasingly been identified as an adulterant in illicit fentanyl supplies and is associated with increased overdose mortality. We previou...
Fentanyl, xylazine, and bromazolam: Urine toxicology trends in a San Francisco safety net opioid treatment patient cohort 2023-2025 [0.03%]
芬太尼、木聚糖和溴唑仑：旧金山安全网阿片类治疗患者群体中毒理学趋势（2023-2025年）
John C Halifax,Lilly Lim,Jennifer Ahern et al.
John C Halifax et al.
Objectives: To gain insights on the illicit drug supply in San Francisco using urine toxicology of opioid use disorder intake patients to assess temporal trends and co-occurrence patterns and detect emerging compounds of ...
Alcohol and pregnancy: Benefits and harms of pregnancy-specific alcohol policies among maternal-infant dyads covered by Medicaid [0.03%]
酒精与怀孕：针对Medicaid覆盖的母婴对群体的孕期特定饮酒政策的好处和危害
Sarah C M Roberts,Emily Dennis,Meenakshi Subbaraman et al.
Sarah C M Roberts et al.
Background: Previous research finds pregnancy-specific alcohol policies are associated with adverse infant/maternal outcomes among people covered by commercial insurance. Here, we examine whether findings generalize to pe...
Cannabis use disorder risk among midlife adults reporting medical and nonmedical cannabis use, 2019-2024 [0.03%]
2019年至2024年自我报告的大麻医疗和非医疗使用者中成年中期人群大麻使用障碍的风险
Yvonne M Terry-McElrath,Megan E Patrick
Yvonne M Terry-McElrath
Background: High-frequency cannabis use is a key cannabis use disorder (CUD) risk factor that also is associated with medical (vs. nonmedical) use. This analysis examined overall and sex- and age-stratified associations b...
Adolescents view cannabis as less harmful than cigarettes, nicotine vapes, and alcohol: Findings from two California school surveys [0.03%]
加州两所学校的调查结果表明青少年认为大麻的危害小于香烟、尼古丁电子烟和酒精
Deepti Agarwal,Jijiang Wang,Shuwen Li et al.
Deepti Agarwal et al.
Background: Perceptions that substances are harmful help protect against their use. The purpose of this study was to investigate adolescent perceptions of the harmfulness of everyday and occasional use of cannabis compare...
Perceived harmfulness of e-cigarettes and heated tobacco products compared to cigarettes: Findings from the 2020 ITC Malaysia survey [0.03%]
基于2020年国际烟草控制项目马来西亚调查的电子烟和加热烟草制品相较于传统卷烟的危害性感知研究
Muhamad Alfakri Mat Noh,Farizah Mohd Hairi,Amer Siddiq Amer Nordin et al.
Muhamad Alfakri Mat Noh et al.
Introduction: Misperceptions about nicotine product harms may influence product use and switching behaviors. Methods: Data were from th...
The effects of acute and repeated M1 agonist VU0364572 administration on cocaine-vs-food choice in male and female Sprague-Dawley rats [0.03%]
急性及重复给予M1激动剂VU0364572对Sprague-Dawley大鼠可卡因与食物选择的影响
Samuel A Marsh,Matthew L Banks
Samuel A Marsh
Cocaine use disorder (CUD) represents a public health crisis for which there are currently no pharmacotherapies. Repeated administration of the muscarinic agonist xanomeline significantly decreased cocaine self-administration. However, the ...
Frequent police contact and nonfatal overdose among people who use drugs in rural Appalachia [0.03%]
阿巴拉契亚农村地区吸毒者与警察的频繁接触及非致命性药物过量事件
Javier A Cepeda,Talia Loeb,Zach R Salazar et al.
Javier A Cepeda et al.
Introduction: Police contact shapes subsequent health practices and outcomes among people who use drugs (PWUD). However, the relationship between police encounters with overdose remains under-researched. We evaluated how ...
Beneficial effects of the rapid vs. standard procedure for injection naltrexone initiation operate through increased adjunctive medication use [0.03%]
快速注射纳曲酮起始程序相对于常规程序的益处在于其能增加辅助药物的使用量
Kara E Rudolph,Shodai Inose,Nicholas T Williams et al.
Kara E Rudolph et al.
Objective: To estimate the extent to which increased use of clonidine and benzodiazepines is associated with the beneficial effect of the rapid versus standard procedure for induction onto extended-release injectable nalt...
GHSR antagonist LEAP2 concentrations negatively correlate with alcohol craving and are modulated by alcohol exposure: Evidence from human and rat studies [0.03%]
人和大鼠研究证据表明GHSR拮抗剂LEAP2浓度与酒精渴求负相关并受酒精暴露调节
Andras H Leko,Mehdi Farokhnia,Elizabeth H Tressler et al.
Andras H Leko et al.
Background: Despite its clinical significance, pharmacological treatment options for alcohol use disorder (AUD) remained limited, which highlights the need for novel therapeutic targets. The ghrelin system has emerged as ...