Concerning the harm-benefit ratio of escitalopram for pediatric generalized anxiety disorder. A critical viewpoint on the evidence and approval process [0.03%]
从证据和审批过程的角度看艾司西酞普兰治疗儿童广泛性焦虑障碍的风险获益比——一种批判性的观点
Martin Plöderl,Mark Horowitz,Florian Naudet et al.
Martin Plöderl et al.
In this commentary we review the recent approval of escitalopram for generalized anxiety disorder (GAD) in children and adolescents. We critically discuss the FDA approval document and the approval trial. In the approval trial, efficacy was...
Medical science and the madness of crowds; context for our COVID pandemic years [0.03%]
医学与群体疯狂；新冠疫情年间的背景分析
Peter Rhodes
Peter Rhodes
Individual autonomy is fragile.We must ask whether we have been swept up with ' a crowd '; perhaps trapped within a ' thought window ', carried by mass narrative, or entranced by the certainty of the totalitarised mind.Loss of the individua...
Association between obesity/overweight in adolescents and low food safety knowledge and practice [0.03%]
肥胖青少年食物安全感知与行为之间的关系
Ghada Mahmoud Khafagy,Raghda Selet,Mai D Sarhan
Ghada Mahmoud Khafagy
BackgroundObesity among adolescents is one of the most prevalent noncommunicable disorders. Currently, around 17% of teenagers are obese and are vulnerable to long-term consequences. Obesity pathophysiology is complicated, varied, and not f...
Adverse drug reactions to the nine-month all-oral and 18-month regimens for multidrug-resistant tuberculosis in Indonesia [0.03%]
印度尼西亚耐多药结核病九个月全口服方案和十八个月方案的不良反应分析
Nina Mariana,Anggi Gayatri,Indah Suci Widyahening et al.
Nina Mariana et al.
BackgroundThe treatment of multidrug-resistant (MDR) tuberculosis (TB) requires the long-term administration of multiple second-line drugs in combination therapy.ObjectiveWe investigated the ADRs to a 9-month all-oral regimen (i.e., pyrazin...
Batch-dependent safety signal: Nationwide analysis of suspected adverse events following COVID-19 vaccination in Germany [0.03%]
基于批次的安全信号：德国对新冠肺炎疫苗接种后疑似不良事件的全国分析
Vibeke Manniche,Vít Karásek,Max Schmeling et al.
Vibeke Manniche et al.
BackgroundPreliminary reports have suggested a batch-dependent safety signal for COVID-19 vaccines. It is important to establish if these findings can be replicated.MethodsWe used publicly available nationwide data from Germany spanning the...
Prevalence and predictors of self-medication among adults in Mbeya Urban, Tanzania [0.03%]
坦桑尼亚姆贝拉市成年人自我药疗的流行率及影响因素
Salum Manguja,Theresia Estomih Nkya
Salum Manguja
BackgroundSelf-medication is a common health-seeking behavior in low- and middle-income countries, influenced by easy drug access and limited health insurance. In Tanzania, particularly in urban areas such as Mbeya, empirical evidence remai...
Trusted evidence for better health: Achievements and barriers over the 10 years of Cochrane Russia [0.03%]
更佳健康的可信证据：Cochrane俄罗斯10年的成就与障碍
Liliya Eugenevna Ziganshina
Liliya Eugenevna Ziganshina
Excess mortality, statistical significance, and causation: Analyzing controversies in COVID-19 vaccine research [0.03%]
超额死亡、统计学意义和因果关系：分析COVID-19疫苗研究中的争议问题
Raphael Lataster
Raphael Lataster
Many thanks to the editors of the International Journal of Risk & Safety in Medicine for inviting me to provide commentary and context on the academic discourses around 4 articles published herein that provide a more balanced view of COVID-...
Comparison of hematological adverse reactions in patients with epilepsy on monotherapy versus polytherapy [0.03%]
单药与多药治疗癫痫患者的血液学不良反应比较分析
Ogunjimi Luqman,Ogunjimi Olabisi,Kasali Adeola et al.
Ogunjimi Luqman et al.
BackgroundThis study compared the effects of anti-seizure medication (ASM) monotherapy and polytherapy on hematological parameters in patients with epilepsy (PWE).ObjectiveTo compare hematological parameters and derived inflammatory indices...
Drug-induced methemoglobinemia in a child with comorbidity and polypragmasia: Case report [0.03%]
合并多种疾病和多种药物治疗的儿童药物所致高铁血红蛋白血症1例报告
Alina B Strok,Maria N Kostyleva,Anna V Kostina
Alina B Strok
Background: The article describes a case of methemoglobinemia in a 4-year-old child with nephrotic syndrome with simultaneous use of therapeutic doses of three drugs that cause methemoglobinemia: lidocaine (topically), benzocaine (topically...