Viscoelastic characterization of diabetic and non-diabetic human adipose tissue [0.03%]
糖尿病和非糖尿病人的脂肪组织的黏弹特性研究
Benjamin A Juliar,Clarissa Strieder-Barboza,Monita Karmakar et al.
Benjamin A Juliar et al.
Background: Obesity-induced chronic inflammation and fibrosis in adipose tissue contributes to the progression of type 2 diabetes mellitus (DM). While fibrosis is known to induce mechanical stiffening of numerous tissue t...
Daniele Borin,Brisa Peña,Matthew R G Taylor et al.
Daniele Borin et al.
Background: Laminopathies are genetic diseases caused by mutations in the nuclear lamina. Objective: Given the clinical impact of lamin...
Herbert Lipowsky
Herbert Lipowsky
Relative shedding of glycosaminoglycans from the endothelial glycocalyx during inflammation and their contribution to stiffness of the glycocalyx [0.03%]
炎症过程中内皮糖萼甘露聚糖相对脱落及其对糖萼刚度的贡献
Herbert H Lipowsky
Herbert H Lipowsky
Background: The endothelial (EC) surface layer (glycocalyx) has been shown to act as a barrier to transvascular exchange of solutes, and adhesion of leukocytes (WBCs) during the inflammatory process. It is a labile struct...
Nitrite may serve as a combination partner and a biomarker for the anti-cancer activity of RRx-001 [0.03%]
亚硝酸盐可能是抗癌药物RRx-001的联合作用因子及其抗肿瘤活性的生物标志物
Selma Cirrik,Elif Ugurel,Ali Cenk Aksu et al.
Selma Cirrik et al.
Background: RRx-001 is an anti-cancer immunotherapeutic that increases the sensitivity of drug resistant tumors via multiple mechanisms which involve binding to hemoglobin and enhancing nitrite reductase activity of deoxy...
Nguyen Ngoc Minh,Hiromichi Obara,Kenji Shimokasa et al.
Nguyen Ngoc Minh et al.
Background: Bile, which is secreted by the liver, is essential for digesting fat and maintaining homeostasis. Although the rheology of bile is very important to its flow, its extensional viscosity has not been studied. ...
Correlation of the cell mechanical behavior and quantified cytoskeletal parameters in normal and cancerous breast cell lines [0.03%]
正常和癌变乳腺细胞系中细胞机械性能与量化细胞骨架参数的相关性研究
Mohammad Tabatabaei,Mohammad Tafazzoli-Shadpour,Mohammad Mehdi Khani
Mohammad Tabatabaei
Background: Cancerous transformation of cells affects their mechanical behavior and cytoskeleton structure. Objective: The objective of...
Comparative Study
Biorheology. 2019;56(4):207-219. DOI:10.3233/BIR-190214 2019
Peter J Butler,Amit Bhatnagar
Peter J Butler
Background: Endothelial cells (ECs) sense the forces from blood flow through the glycocalyx, a carbohydrate rich luminal surface layer decorating most cells, and through forces transmitted through focal adhesions (FAs) on...
Sen Lu,Shusheng Zhang
Sen Lu
Background: Atherosclerotic lesions develop preferentially at certain sites in the human arterial system, such as the inner wall of curved segments and the outer wall of bifurcations. Local wall shear stress (WSS) and con...
The cancer cell glycocalyx proteoglycan Glypican-1 mediates interstitial flow mechanotransduction to enhance cell migration and metastasis [0.03%]
癌细胞糖萼蛋白聚糖Glypican-1介导流体流动的力学信号转导以增强细胞迁移和转移
Heriberto Moran,Limary M Cancel,Mariya A Mayer et al.
Heriberto Moran et al.
Background: Previous studies have demonstrated that the glycosaminoglycans (GAGs) heparan sulfate (HS) and hyaluronic acid (HA) are mechanosensors for interstitial flow on cancer cells. The proteins that link the GAGs to ...