Dina Raafat,Michael Otto,Kevin Reppschläger et al.
Dina Raafat et al.
Staphylococcus aureus (S. aureus) is a notorious pathogen and one of the most frequent causes of biofilm-related infections. The treatment of S. aureus biofilms is hampered by the ability of the biofilm structure to shield bacteria from ant...
Crossing the Intestinal Barrier via Listeria Adhesion Protein and Internalin A [0.03%]
利用李斯特菌粘附蛋白和内收蛋白穿越肠屏障
Rishi Drolia,Arun K Bhunia
Rishi Drolia
The intestinal epithelial cell lining provides the first line of defense, yet foodborne pathogens such as Listeria monocytogenes can overcome this barrier; however, the underlying mechanism is not well understood. Though the host M cells in...
Integrated Signaling Pathways Mediate Bordetella Immunomodulation, Persistence, and Transmission [0.03%]
整合信号通路调节伯氏菌免疫调节、持久性和传播性
M C Gestal,L T Whitesides,E T Harvill
M C Gestal
The mammalian immune system includes a sophisticated array of antimicrobial mechanisms. However, successful pathogens have developed subversive strategies to detect, modulate, and/or evade immune control and clearance. Independent disciplin...
RTX Adhesins are Key Bacterial Surface Megaproteins in the Formation of Biofilms [0.03%]
RTX粘附分子是细菌生物被膜形成的关键表面巨蛋白
Shuaiqi Guo,Tyler D R Vance,Corey A Stevens et al.
Shuaiqi Guo et al.
Gram-negative bacteria produce repeats-in-toxin adhesion proteins (RTX adhesins) to facilitate microbial adhesion. These large, multidomain proteins share a common architecture comprised of four regions. First to emerge from the bacterium, ...
Chung-Yin Leung,Joshua S Weitz
Chung-Yin Leung
Commensal bacteria have been identified as critical drivers of host resilience to pathogen invasion. The resulting 'competitive exclusion' of pathogens by commensals can arise via multiple mechanisms, including direct competition for sites ...
Ashley Best,Yousef Abu Kwaik
Ashley Best
The host is a nutrient-rich niche for microbial pathogens, but one that comes with obstacles and challenges. Many intracellular pathogens like Legionella pneumophila, Coxiella burnetii, Listeria monocytogenes, and Chlamydia trachomatis have...
Interplay between Influenza Virus and the Host RNA Polymerase II Transcriptional Machinery [0.03%]
流感病毒与宿主RNA聚合酶II转录装置的相互作用
Alexander P Walker,Ervin Fodor
Alexander P Walker
The influenza virus RNA-dependent RNA polymerase (RdRP) cleaves the 5' end of nascent capped host RNAs and uses the capped RNA fragment to prime viral transcription in a mechanism called 'cap snatching'. Cap snatching requires an intimate a...
Nicolas Papon,Brad M Binder
Nicolas Papon
Ethylene is a gas and a plant hormone with wide ranging effects and a well defined signaling pathway. The recent identification of ethylene receptors in various microorganisms provides new insights into the early propagation of the ethylene...
Research, Innovation, and Policy: An Alliance Combating Antimicrobial Resistance [0.03%]
研究、创新与政策合力对抗微生物耐药性
Arjon J van Hengel,Laura Marin
Arjon J van Hengel
The surge in antimicrobial resistance (AMR) has created a crisis that has become top priority for public health and global policy. Researchers, developers, innovators, funders, and policymakers need to curb AMR's rising trend by acting syne...
Ménage à trois: Virus, Host, and Microbiota in Experimental Infection Models [0.03%]
三元关系：病毒、宿主和微生物群在实验感染模型中的相互作用
Beryl Mazel-Sanchez,Soner Yildiz,Mirco Schmolke
Beryl Mazel-Sanchez
Infections of mammals with pathogenic viruses occur mostly in the polymicrobial environment of mucosal surfaces or the skin. In recent years our understanding of immune modulation by the commensal microbiota has increased dramatically. The ...