Zsolt Boldogkői,Norbert Moldován,Zsolt Balázs et al.
Zsolt Boldogkői et al.
Long-read sequencing (LRS) has become increasingly popular due to its strengths in de novo assembly and in resolving complex DNA regions as well as in determining full-length RNA molecules. Two important LRS technologies have been developed...
Maren Wehrs,Deepti Tanjore,Thomas Eng et al.
Maren Wehrs et al.
Systems biology and synthetic biology are increasingly used to examine and modulate complex biological systems. As such, many issues arising during scaling-up microbial production processes can be addressed using these approaches. We review...
Gail Teitzel
Gail Teitzel
Efflux-Pump Upregulation: From Tolerance to High-level Antibiotic Resistance? [0.03%]
外排泵上调表达：从抗生素耐受性到高水品的抗生素抗性？
Jakob Frimodt-Møller,Anders Løbner-Olesen
Jakob Frimodt-Møller
A recent study shows that high expression of the efflux-pump AcrAB-TolC, which increases antibiotic tolerance, reduces DNA mismatch repair in Escherichia coli to promote spontaneous mutations. Because mutations in target genes can lead to h...
Caressa N Tsai,Brian K Coombes
Caressa N Tsai
The complex infection environment within hosts exerts unique stresses across tissues and cell types, selecting for phenotypic heterogeneity in bacterial populations. Pathogens maintain variability during infection as a strategy to cope with...
Erin P Price,Derek S Sarovich
Erin P Price
Bacterial infections are the primary cause of respiratory decline and mortality in cystic fibrosis (CF) patients. In a recent study, Diaz Caballero and colleagues [1] (PLoS Pathog. 2018;14:e1007453) catalogued the molecular adaptation of a ...
Hepatitis C Virus [0.03%]
丙型肝炎病毒
Thomas Pietschmann,Richard J P Brown
Thomas Pietschmann
Hepatitis C virus (HCV) is an enveloped, RNA virus transmitted through blood-to-blood contact. It infects humans only and primarily targets liver cells. HCV evades innate and adaptive immunity and establishes chronic infections in 70% of ca...
Madhusmita Dehingia,Atanu Adak,Mojibur R Khan
Madhusmita Dehingia
Global research is focused on understanding the factors affecting human gut microbiota vis-à-vis health. Brooks et al. [PLoS Biol. (2018) 16, e2006842] has reported a group of microbial taxa that vary across ethnicity in the USA (AGP and H...
Alternatives to Conventional Antibiotics in the Era of Antimicrobial Resistance [0.03%]
抗生素耐药时代替代传统抗生素的方法
Chandradhish Ghosh,Paramita Sarkar,Rahaf Issa et al.
Chandradhish Ghosh et al.
As more antibiotics are rendered ineffective by drug-resistant bacteria, focus must be shifted towards alternative therapies for treating infections. Although several alternatives already exist in nature, the challenge is to implement them ...
The Road Not Taken: The Rumen Microbiome, Functional Groups, and Community States [0.03%]
未选择的路： rumen微生物组、功能群和社区状态
Sarah Moraïs,Itzhak Mizrahi
Sarah Moraïs
The rumen ecosystem represents a classic example of host-microbiome symbiosis. In this obligatory relationship, the host feeds on plant fibers that can only be degraded through a set of complex metabolic cascades, exclusively encoded in rum...