How BspC from Streptococcus agalactiae Interacts with Host Vimentin during Meningitis [0.03%]
BspC蛋白介导的肠球菌与宿主中间丝蛋白 Vimenten 的相互作用及其对脑膜炎感染的影响研究
Concetta Beninati,Agata Famà,Giuseppe Teti
Concetta Beninati
Streptococcus agalactiae meningitis is a frequent neonatal disease associated with high mortality and permanent neurological damage. Deng et al. (PLoS Pathog., 2019) now show that interactions between the bacterial protein BspC and host cel...
Geneviève Lajoie,Steven W Kembel
Geneviève Lajoie
There is an increasing interest in applying trait-based approaches to microbial ecology, but the question of how and why to do it is still lagging behind. By anchoring our discussion of these questions in a framework derived from epistemolo...
Bystander Selection for Antimicrobial Resistance: Implications for Patient Health [0.03%]
抗菌药抗性的旁观者选择：对患者健康的影响
Valerie J Morley,Robert J Woods,Andrew F Read
Valerie J Morley
Antimicrobial therapy promotes resistance emergence in target infections and in off-target microbiota. Off-target resistance emergence threatens patient health when off-target populations are a source of future infections, as they are for m...
Fluidic Force Microscopy Captures Amyloid Bonds between Microbial Cells [0.03%]
流体力学生物力学检测微生物细胞间的淀粉样蛋白相互作用
Jérôme Dehullu,Julia A Vorholt,Peter N Lipke et al.
Jérôme Dehullu et al.
Fluidic force microscopy (FluidFM) is a recent force-controlled pipette technology that enables manipulation of single cells. FluidFM can be used for quantification of forces between single cells, and a novel mode of cell-cell adhesion was ...
Bing Chen
Bing Chen
HIV-1 envelope glycoprotein [Env; trimeric (gp160)3 cleaved to (gp120/gp41)3] attaches the virion to a susceptible cell and induces fusion of viral and cell membranes to initiate infection. It interacts with the primary receptor CD4 and cor...
Tanita Wein,Devani Romero Picazo,Frances Blow et al.
Tanita Wein et al.
Symbiotic interactions between eukaryotes and prokaryotes are widespread in nature. Here we offer a conceptual framework to study the evolutionary origins and ecological circumstances of species in beneficial symbiosis. We posit that mutual...
Making the Best of Aggression: The Many Dimensions of Bacterial Toxin Regulation [0.03%]
化弊为利：细菌毒素调控的多种维度
Diego Gonzalez,Despoina A I Mavridou
Diego Gonzalez
Most bacteria use toxins to exclude competitors. As the synthesis and delivery of these molecules entail considerable costs for the producers, their expression is tightly regulated, often by molecular systems detecting physiological stresse...
Qiu Sun,Xiao Du,Wei Cheng
Qiu Sun
Structures of the multiple arthritogenic alphavirus receptor MXRA8 as well as MXRA8 in complex with chikungunya virus (Song et al., Cell, 2019; Basore et al., Cell, 2019) have revealed the mechanism underlying viral invasion and could facil...
Fangfang Li,Aiming Wang
Fangfang Li
RNA silencing is a fundamental, evolutionarily conserved mechanism that regulates gene expression in eukaryotes. It also functions as a primary immune defense in microbes, such as viruses in plants. In addition to RNA silencing, RNA decay a...
Guillaume Duménil
Guillaume Duménil
In the age of antibiotic resistance, strategies targeting virulence traits of bacteria are the focus of intense study. Two such studies came out independently a week apart showing that bacterial type IV pili are a promising therapeutic targ...