Microbial Control of Intestinal Homeostasis via Enteroendocrine Cell Innate Immune Signaling [0.03%]
肠内分泌细胞固有免疫信号通过肠道微生物控制肠道稳态
Paula I Watnick,Bat-Erdene Jugder
Paula I Watnick
A community of commensal microbes, known as the intestinal microbiota, resides within the gastrointestinal tract of animals and plays a role in maintenance of host metabolic homeostasis and resistance to pathogen invasion. Enteroendocrine c...
Joana Castro,Kimberly K Jefferson,Nuno Cerca
Joana Castro
Gardnerella vaginalis has been considered a pivotal player in the progression of bacterial vaginosis (BV), a condition associated with serious health complications. However, G. vaginalis is also commonly found in asymptomatic or BV-negative...
Rachel Fearns
Rachel Fearns
Respiratory syncytial virus (RSV) inflicts a significant toll on human life. An essential element of the virus is its polymerase, a complex capable of transcribing and replicating the viral genome. In an exciting new advance, Gilman et al. ...
Influenza A Virus Hemagglutinin-Neuraminidase-Receptor Balance: Preserving Virus Motility [0.03%]
流感病毒血凝素-神经氨酸酶-受体平衡：保持病毒运动能力
Erik de Vries,Wenjuan Du,Hongbo Guo et al.
Erik de Vries et al.
Influenza A viruses (IAVs) occasionally cross the species barrier and adapt to novel host species. This requires readjustment of the functional balance of the sialic acid receptor-binding hemagglutinin (HA) and the receptor-destroying neura...
Trends in Systems Biology for the Analysis and Engineering of Clostridium acetobutylicum Metabolism [0.03%]
系统生物学在分析和工程研究溶剂产生菌丁酸梭菌代谢中的应用趋势分析
Minyeong Yoo,Ngoc-Phuong-Thao Nguyen,Philippe Soucaille
Minyeong Yoo
Clostridium acetobutylicum has received renewed interest worldwide as a promising producer of biofuels and bulk chemicals such as n-butanol, 1,3-propanediol, 1,3-butanediol, isopropanol, and butyrate. To develop commercial processes for the...
Alessandra De Leo,Abram Calderon,Paul M Lieberman
Alessandra De Leo
The human DNA tumor viruses Epstein-Barr virus (EBV), Kaposi's sarcoma-associated herpesvirus (KSHV), and human papillomavirus (HPV) share the common property of persisting as multicopy episomes in the nuclei of rapidly dividing host cells....
Glutamylation of Bacterial Ubiquitin Ligases by a Legionella Pseudokinase [0.03%]
利斯特氏菌假激酶对细菌泛素连接酶的谷氨酰胺化作用
Alan G Sulpizio,Marena E Minelli,Yuxin Mao
Alan G Sulpizio
Legionella pneumophila encodes a family of phosphoribosyl ubiquitination ligases (SidE) essential for the bacterium to establish successful infection. Four independent studies now show that the SidE family of ubiquitin ligases are regulated...
Filipe M Cerqueira,Amanda L Photenhauer,Rebecca M Pollet et al.
Filipe M Cerqueira et al.
Starch is a polymer of glucose and is one of the most abundant carbohydrates in a Western diet. Resistant starch escapes digestion by host small intestinal glucoamylases and transits the colon where it is degraded by the combined efforts of...
Natural Host-Induced Gene Silencing Offers New Opportunities to Engineer Disease Resistance [0.03%]
自然诱发的基因沉默在疾病抗性育种中大有可为
Yingnan Hou,Wenbo Ma
Yingnan Hou
RNA silencing is an essential gene-regulation mechanism in eukaryotic organisms. Guided by small RNAs (sRNAs) of 20-25 nt in length, RNA silencing broadly governs a wide range of biological processes. In addition to regulating endogenous ge...
Margarida C Gomes,Serge Mostowy
Margarida C Gomes
Zebrafish (Danio rerio) larvae are widely recognized for studying host-pathogen interactions in vivo because of their optical transparency, genetic manipulability, and translational potential. The development of the zebrafish immune system ...