Prasun Kumar,Jin-Hyung Lee,Haluk Beyenal et al.
Prasun Kumar et al.
Fatty acids (FAs) have emerged as a potential alternative to conventional antibiotics. Since many microbes respond differently to a variety of natural and synthetic FAs, substantial efforts have been made to understand the unique features o...
Alexander Kehl,Janina Noster,Michael Hensel
Alexander Kehl
Salmonella enterica is an important gastrointestinal and facultative intracellular pathogen. After invasion of host cells, it resides in a specialized, replication-permissive compartment, the Salmonella-containing vacuole (SCV). During matu...
Synthetic Biology for Manipulating Quorum Sensing in Microbial Consortia [0.03%]
合成生物学在操纵微生物菌群中的群体感应方面的应用
Kristina Stephens,William E Bentley
Kristina Stephens
Bacteria exist as communities in diverse multispecies environments. Quorum sensing, a process for cell-cell communication, allows individual bacteria to glean information about their surroundings and coordinate activities with their neighbo...
Microbiome in Colorectal Cancer: How to Get from Meta-omics to Mechanism? [0.03%]
结直肠癌中的微生物组：如何从元组学研究入手揭示机制？
Dominik Ternes,Jessica Karta,Mina Tsenkova et al.
Dominik Ternes et al.
Mounting evidence from metagenomic analyses suggests that a state of pathological microbial imbalance or dysbiosis is prevalent in the gut of patients with colorectal cancer. Several bacterial taxa have been identified of which representati...
Contact-Dependent Interbacterial Antagonism Mediated by Protein Secretion Machines [0.03%]
由蛋白质分泌机器介导的接触依赖性菌间拮抗作用
Timothy A Klein,Shehryar Ahmad,John C Whitney
Timothy A Klein
To establish and maintain an ecological niche, bacteria employ a wide range of pathways to inhibit the growth of their microbial competitors. Some of these pathways, such as those that produce antibiotics or bacteriocins, exert toxicity on ...
The Evolution of Protein Secretion Systems by Co-option and Tinkering of Cellular Machineries [0.03%]
利用细胞机器的宏扩展和改造而产生的蛋白质分泌系统的进化
Rémi Denise,Sophie S Abby,Eduardo P C Rocha
Rémi Denise
Protein secretion is important for many biotic and abiotic interactions. The evolution of protein secretion systems of bacteria, and related nanomachines, occurred by the co-option of machineries for motility, conjugation, injection, or adh...
Plastic Circuits: Regulatory Flexibility in Fine Tuning Pathogen Success [0.03%]
塑料电路：调节灵活性以微调病原体的成功率
Nicky O&#x;Boyle,Natasha C A Turner,Andrew J Roe et al.
Nicky O&#x;Boyle et al.
Bacterial pathogens employ diverse fitness and virulence mechanisms to gain an advantage in competitive niches. These lifestyle-specific traits require integration into the regulatory network of the cell and are often controlled by pre-exis...
The crAss-like Phage Group: How Metagenomics Reshaped the Human Virome [0.03%]
crAss样噬菌体群：元基因组学如何重塑人类病毒组
Eugene V Koonin,Natalya Yutin
Eugene V Koonin
Metagenomics is currently the primary means for identifying new viruses. One of the most impactful metagenomic discoveries is that of crAssphage, the most abundant human-associated virus that is found in about 50% of human gut viromes where...
Kate Ligthart,Clara Belzer,Willem M de Vos et al.
Kate Ligthart et al.
Cell-surface-located proteinaceous appendages, such as flagella and fimbriae or pili, are ubiquitous in bacterial communities. Here, we focus on conserved type IV pili (T4P) produced by bacteria in the intestinal tract, one of the most dens...
Amy D Willis,Samuel S Minot
Amy D Willis
Manipulating the microbiome has enormous potential to treat important human diseases. Microbiome surveys are often used to identify potential therapeutic targets by finding associations between microbial elements and disease status. We argu...