Jiaqi Fu,Zhao-Qing Luo,Jiazhang Qiu
Jiaqi Fu
Protein post-translational modifications (PTMs) serve as essential molecular switches that dynamically modulate cell signaling in response to developmental or external cues. Effective interference with host signaling is critical for success...
Pathobiont immune tuning: the untold consequences of Staphylococcus aureus exposure on host immunity [0.03%]
病原菌对免疫的调节作用——金黄色葡萄球菌接触对宿主免疫的未被充分认知的影响
Seán C Cahill,Elisabetta Soldaini,Rachel M McLoughlin
Seán C Cahill
Staphylococcus aureus is a formidable pathogen and major challenge to human health. However, the bacterium is dichotomous and also acts as an asymptomatic coloniser. Given its ubiquity, every individual has been exposed to the bacterium, wh...
Xia Shu,Yunpeng Liu
Xia Shu
Stable SynCom design remains challenging due to unpredictable microbial interactions. Contrary to the traditional focus on broad-spectrum strains, Wang et al. revealed that narrow-spectrum bacteria act as metabolic hubs, promoting cooperati...
Boyang Song,Wencheng Shi,Dingjiacheng Jia
Boyang Song
Beyond the commonly considered factor of diet, small-molecule drugs have been identified as effectors of microbiota composition. Recently, two studies (Grießhammer et al. and Kumar et al.) reported that non-antibiotics, like antibiotics, c...
RNA modifications in plant pathogenic fungi: from epitranscriptomics to antifungal strategies [0.03%]
植物病原真菌中的RNA修饰：从表观转录组学到抗真菌策略
Hong Hu,Yinan Li,Ziwei Lv et al.
Hong Hu et al.
Traditional antifungal agents such as polyene, azole, and echinocandin antifungals are restricted because of antifungal resistance and off-target effects. Given these limitations, there is an urgent need to explore novel antifungal strategi...
Tobias Baril,Daniel Croll
Tobias Baril
Recent research on human and crop fungal pathogens has highlighted a set of unexpected and seemingly unrelated mechanisms fuelling adaptation to drugs and the host immune system. These mechanisms include the loss of RNA interference (RNAi) ...
Luna Eresta Jaya,Ilana L Brito
Luna Eresta Jaya
Antibiotic use can significantly alter the gut microbiome, impacting health outcomes across diverse regions. Geographic differences in baseline microbiome composition, antibiotic-resistance gene (ARG) carriage, antibiotic usage patterns, an...
Geographic diversity in inflammatory bowel disease genetics and microbiome [0.03%]
炎症性肠病遗传学及微生物群的地域差异性
Fangjia Hao,Wenyi Zhu,Jiaying Zheng et al.
Fangjia Hao et al.
Inflammatory bowel disease (IBD) is characterized by dysregulation of the immune response to gut microbiota, a phenomenon that intertwines with environmental influences and manifests as intestinal inflammation in genetically susceptible hos...
Jinal N Bhiman,Jennifer Serwanga,Chinedu A Ugwu et al.
Jinal N Bhiman et al.
The Global Immunology and Immune Sequencing for Epidemic Response (GIISER) network, established in 2021, exemplifies the power of South-South collaboration in pandemic preparedness and response. Emerging from the COVID-19 crisis, GIISER int...
Francisco Rodriguez-Valera,Carmen Molina-Pardines
Francisco Rodriguez-Valera
The prokaryotic pangenome, the full complement of genes within a species, is strikingly large. To understand how ecological forces shape this diversity, it is useful to examine the variable gene pool within a single population, defined as c...