The Role of Integrative and Conjugative Elements in Antibiotic Resistance Evolution [0.03%]
整合和接合元件在抗生素抗性进化中的作用
João Botelho,Hinrich Schulenburg
João Botelho
Mobile genetic elements (MGEs), such as plasmids and integrative and conjugative elements (ICEs), are main drivers for the spread of antibiotic resistance (AR). Coevolution between bacteria and plasmids shapes the transfer and stability of ...
Valerie Betting,Ronald P Van Rij
Valerie Betting
RNA interference (RNAi) is a powerful host defense mechanism against viruses. As a counter-defense, many viruses encode suppressors of RNAi, which - in plants - has provoked counter-counter-defense strategies. Recently, a mechanism was prop...
Carriage of Colibactin-producing Bacteria and Colorectal Cancer Risk [0.03%]
产生coliбактิน的菌株与结直肠癌风险的关系
Vadim Dubinsky,Iris Dotan,Uri Gophna
Vadim Dubinsky
Colibactin is a genotoxic molecule, produced primarily by Escherichia coli. Colibactin causes DNA damage that may lead to colorectal cancer. Here we review recent advances in the study of colibactin and propose a focus on patients with infl...
Spiking Pandemic Potential: Structural and Immunological Aspects of SARS-CoV-2 [0.03%]
刺突蛋白的流行潜力：SARS-CoV-2的结构和免疫学方面
Ying-Ting Wang,Sara Landeras-Bueno,Li-En Hsieh et al.
Ying-Ting Wang et al.
SARS-Coronavirus-2 (SARS-CoV-2) causes Coronavirus disease 2019 (COVID-19), an infectious respiratory disease causing thousands of deaths and overwhelming public health systems. The international spread of SARS-CoV-2 is associated with the ...
Xu Peng,David Mayo-Muñoz,Yuvaraj Bhoobalan-Chitty et al.
Xu Peng et al.
Anti-CRISPR (Acr) proteins are natural inhibitors of CRISPR-Cas immune systems. To date, Acrs inhibiting types I, II, III, V, and VI CRISPR-Cas systems have been characterized. While most known Acrs are derived from bacterial phages and pro...
New Paradigms of Pilus Assembly Mechanisms in Gram-Positive Actinobacteria [0.03%]
革兰氏阳性放线菌菌毛装配机制的新范式
Nicholas A Ramirez,Asis Das,Hung Ton-That
Nicholas A Ramirez
Adhesive pili in Gram-positive bacteria represent a variety of extracellular multiprotein polymers that mediate bacterial colonization of specific host tissues and associated pathogenesis. Pili are assembled in two distinct but coupled step...
Chronic Immune Activation in TB/HIV Co-infection: (Trends in Microbiology 28, 619-632; 2020) [0.03%]
HIV/TB共感染的慢性免疫激活：《微生物学趋势》(Trends in Microbiology 28, 619-632; 2020)
Riti Sharan,Allison N Bucşan,Shashank Ganatra et al.
Riti Sharan et al.
Published Erratum
Trends in microbiology. 2020 Aug;28(8):699. DOI:10.1016/j.tim.2020.05.006 2020
Jon T Skare,Brandon L Garcia
Jon T Skare
The complement system is an ancient arm of the innate immune system that plays important roles in pathogen recognition and elimination. Upon activation by microbes, complement opsonizes bacterial surfaces, recruits professional phagocytes, ...
Zhijie Zhang,Mark van Kleunen,Lutz Becks et al.
Zhijie Zhang et al.
Understanding the general rules of microbial interactions is central for advancing microbial ecology. Recent studies show that interaction range, interaction strength, and community context determine bacterial interactions and the coexisten...