Antimicrobial efflux and biofilms: an interplay leading to emergent resistance evolution [0.03%]
抗菌剂外排与生物膜：导致获得性耐药进化的一种相互作用
Silvia Vareschi,Valerie Jaut,Srinivasan Vijay et al.
Silvia Vareschi et al.
The biofilm mode of growth and drug efflux are both important factors that impede the treatment of bacterial infections with antimicrobials. Decades of work have uncovered the mechanisms involved in both efflux and biofilm-mediated antimicr...
Héloïse Rytter,Hannah Sturgeon,Benoit Chassaing
Héloïse Rytter
The intestinal microbiota plays a crucial role in maintaining host health by participating in various beneficial functions. However, under certain conditions, it can contribute to the development of inflammatory bowel disease (IBD) and othe...
Philip S Stewart
Philip S Stewart
A quantitative framework is proposed for analyzing bacterial dynamics at the site of a biofilm infection. A key parameter in this analysis is the bacterial specific growth rate. The literature was surveyed for quantitative measurements of b...
Pedro F Vale
Pedro F Vale
Laura Toribio-Celestino,Alvaro San Millan
Laura Toribio-Celestino
Antimicrobial resistance (AMR) is one of the most pressing global health problems, with plasmids playing a central role in its evolution and dissemination. Over the past decades, many studies have investigated the ecoevolutionary dynamics b...
Advances in host-directed therapy for tuberculosis and HIV coinfection: enhancing immune responses [0.03%]
宿主导向疗法治疗结核病和艾滋病双重感染研究进展：增强免疫反应方面
Preena Prasanna,Bianca Herrera,Larry S Schlesinger et al.
Preena Prasanna et al.
Tuberculosis (TB) and HIV coinfection present a significant global health challenge worldwide. While most individuals infected with Mycobacterium tuberculosis (Mtb) have clinically asymptomatic latent TB infection (LTBI), those with immunos...
Symbiotic bacteria and pest control: plant toxins, chemical pesticides, and fungal entomopathogens [0.03%]
互利共生细菌与害虫控制：植物毒素、化学农药和真菌杀虫剂
Joshua A Thia,Ashritha P S Dorai,Ary A Hoffmann
Joshua A Thia
Bacterial symbionts in pests are being increasingly investigated to assess their potential uses for sustainable control approaches. We undertook a review and analysis of the impacts of endosymbionts and gut symbionts on responses to toxins ...
Cutting-edge tools for structural biology: bringing AlphaFold to the people [0.03%]
结构生物学的前沿工具：让AlphaFold惠及大众
Christoph Elfmann,Jörg Stülke
Christoph Elfmann
The recent application of artificial intelligence-based prediction of protein and protein complex structures by AlphaFold has revolutionized biology. Here, we give an overview of the tools that make this revolution accessible to experimenta...
Bacterial lectins: multifunctional tools in pathogenesis and possible drug targets [0.03%]
细菌凝集素：病原作用的多功能工具及潜在药物靶点
Mario Fares,Anne Imberty,Alexander Titz
Mario Fares
Glycans are vital macromolecules with diverse biological roles, decoded by lectins - specialized carbohydrate-binding proteins crucial in pathogenesis. The WHO identifies bacterial antimicrobial resistance (AMR) as a critical global health ...
Dong Zhang,Jiang Tao Gao,Shun Gui Zhou
Dong Zhang
Electric fields in sediments and soils are critical yet overlooked drivers of microbial ecology. This review examines the importance of electrotaxis in shaping microbial community dynamics and ecology models, surpassing traditional framewor...