Isaac M Klimasmith,Angela D Kent
Isaac M Klimasmith
While large inputs of synthetic nitrogen fertilizers enable our current rate of crop production and feed a growing global population, these fertilizers come at a heavy environmental cost. Driven by microbial processes, excess applied nitrog...
Machine-learning approaches prevent post-treatment resistance-gaining bacterial recurrences [0.03%]
机器学习方法可防止获得耐药性的治疗后细菌复发
Marwan Osman,Rafael Mahieu,Matthieu Eveillard
Marwan Osman
Despite susceptibility testing, recurrent infections are common and are associated with resistance. Using whole-genome sequencing, Stracy et al. demonstrated that recurrence is often driven by a different strain than the original infection....
Connecting the dots: understanding how human mobility shapes TB epidemics [0.03%]
牵线连点：人类活动对结核病流行的影响机制探究
Tyler S Brown,D Ashley Robinson,Caroline O Buckee et al.
Tyler S Brown et al.
Tuberculosis (TB) remains a leading infectious cause of death worldwide. Reducing TB infections and TB-related deaths rests ultimately on stopping forward transmission from infectious to susceptible individuals. Critical to this effort is u...
Ulrich G Mueller,Timothy A Linksvayer
Ulrich G Mueller
Microbiome breeding is a new artificial selection technique that seeks to change the genetic composition of microbiomes in order to benefit plant or animal hosts. Recent experimental and theoretical analyses have shown that microbiome breed...
Insights into endogenous Bifidobacterium species in the human gut microbiota during adulthood [0.03%]
人类肠道微生物群中双歧杆菌属内源物种在成人期的特征分析
Muriel Derrien,Francesca Turroni,Marco Ventura et al.
Muriel Derrien et al.
Bifidobacteria are among the earliest and most abundant bacterial colonizers of the neonatal gut in many mammals, where they elicit purported host health benefits. While early life-associated dynamics and diversity, as well as the metabolic...
Unearthing terrestrial extreme microbiomes for searching terrestrial-like life in the Solar System [0.03%]
挖掘地球极端微生物群以寻找太阳系类地生命形式
Claudia Coleine,Manuel Delgado-Baquerizo
Claudia Coleine
The possibility of life elsewhere in the universe has fascinated humankind for ages. To the best of our knowledge, life, as we know it, is limited to planet Earth; yet current investigation suggests that life might be more common than previ...
Bag it, tag it: ubiquitin ligases and host resistance to Mycobacterium tuberculosis [0.03%]
包起来，标出来：泛素连接酶与宿主抵抗结核杆菌感染
Priscila C Campos,Danielle T Cunha,Luiz P Souza-Costa et al.
Priscila C Campos et al.
Infection with Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB), remains a significant global epidemic. Host resistance to Mtb depends on both adaptive and innate immunity mechanisms, including development of ant...
Antibacterial contact-dependent proteins secreted by Gram-negative cystic fibrosis respiratory pathogens [0.03%]
细胞间接触依赖型抗菌蛋白的分泌是囊性纤维化呼吸系统病原菌的一种革兰氏阴性菌特征
Cristian V Crisan,Joanna B Goldberg
Cristian V Crisan
Cystic fibrosis (CF) is a genetic disease that affects almost 100 000 people worldwide. CF patients suffer from chronic bacterial airway infections that are often polymicrobial and are the leading cause of mortality. Interactions between pa...
William B Ludington
William B Ludington
The complexity of microbial communities suggests prevalent interactions involving more than just pairs of species. These so-called higher-order interactions may reveal new molecules that enable bacteria to deal with complex environments. Th...
CRISPR-Cas and restriction-modification team up to achieve long-term immunity [0.03%]
CRISPR-Cas和限制修饰系统联手实现长期免疫
Jean Cury,Aude Bernheim
Jean Cury
Bacteria have been shown to harbor a growing arsenal of various defense systems against phages. Maguin et al. have uncovered how two of the most frequent defense systems interact: the clustered regularly interspaced short palindromic repeat...