PurFect timing: revisiting purine metabolism for tuberculosis treatment [0.03%]
完美时机：重新审视嘌呤代谢与结核病治疗的关系
Richard J Wall,Valerie Mizrahi,Dirk A Lamprecht
Richard J Wall
Eradication of tuberculosis requires new drugs targeting novel pathways. Although purine metabolism represents an essential antitubercular target, concerns about host nucleobase rescue limited its exploration. New data demonstrate that nucl...
David A Good,Simone Renwick,Hortensia Caballero-Arias et al.
David A Good et al.
This paper proposes an ethical framework for microbiome research with the Yanomami, an Indigenous Amazonian people, grounded in collaboration, reciprocity, and relational accountability. Key elements include dedicated funding for community-...
Yong-Guan Zhu,Qing-Lin Chen,Si-Yu Zhang et al.
Yong-Guan Zhu et al.
Soils are critical reservoirs of antibiotic-resistance genes (ARGs) and antibiotic-resistant bacteria (ARB), serving as interfaces among human, animal, plant, and environmental microbiomes. While many studies have profiled soil ARGs, most r...
Romain Villa,Camille Martin-Gallausiaux,Simonetta Gribaldo et al.
Romain Villa et al.
Chennan Yang,Xiaobo Zhong,Dennis Claessen
Chennan Yang
Cellulose, a ubiquitous polysaccharide with critical roles in life, provides structural integrity to cells in plants and aids biofilm formation in many bacteria. Although bacterial cellulose biosynthesis is well studied in certain groups, i...
Revisiting the order Nitrospirales: phylogeny, habitat range, metabolism [0.03%]
重访氧化氮螺菌目：系统发育、栖息地和代谢特性
Hirotsugu Fujitani
Hirotsugu Fujitani
Nitrification is a key process in the nitrogen cycle performed by several functional groups of chemolithoautotrophic microorganisms. The order Nitrospirales plays a central role in this process. Comprehensive genomic analysis conducted by K...
Argentine microbiology: between scientific legacy and systemic fragility [0.03%]
阿根廷微生物学：在科学遗产与系统脆弱性之间
Eleonora García Véscovi,Andrea M Smania,Diego Omar Serra
Eleonora García Véscovi
Argentina's microbiology, born from 19th-century public health challenges, built enduring institutions and contributed globally to the fight against infectious diseases, to agriculture, and to biotechnology. Yet chronic underfunding, politi...
Guanwang Shen,Yu Guo,Min Wu et al.
Guanwang Shen et al.
Bacteria and viruses have coevolved for billions of years. Recently, Zhang et al. identified the Kiwa defense system as a membrane-embedded sensor that detects early phage invasion and coordinates antiviral response; it collaborates with Re...
Pradeepa Pushparaj,Gunilla B Karlsson Hedestam
Pradeepa Pushparaj
While often overlooked in studies of influenza antibody responses, the virally encoded neuraminidase (NA) is emerging as an attractive vaccine target due to its comparably high sequence conservation. Recent studies by Jo et al., Lederhofer ...
From structure to immunity: how skin shapes age-related vulnerability to Chikungunya virus infections [0.03%]
从结构到免疫：皮肤如何塑造对 Chicungunya病毒感染的年龄相关脆弱性
Vanessa Kexin Neo,Siew-Wai Fong,Lisa F P Ng
Vanessa Kexin Neo
Arboviral diseases are resurging globally, with Chikungunya virus (CHIKV) demonstrating a troubling capacity for large-scale outbreaks. In 2024, CHIKV re-emerged in Réunion Island with 47 500 cases and 12 deaths reported by May 2025. Notab...