Pathogen-defending deubiquitinase possesses distinct specificity towards K6-polyubiquitination [0.03%]
具有降解K6多泛素化底物特异性的抗病原去泛素酶
Zhengrui Zhang,Chittaranjan Das
Zhengrui Zhang
The bacterial pathogen Legionella pneumophila encodes numerous effectors to manipulate host ubiquitin signaling. Recently, Warren et al. revealed the structural basis of K6-polyubiquitination recognition by Legionella deubiquitinase LotA, w...
Frenemies of the soil: Bacillus and Pseudomonas interspecies interactions [0.03%]
土壤中的敌友关系：芽孢杆菌和假单胞菌种间相互作用
Mark Lyng,Ákos T Kovács
Mark Lyng
Bacillus and Pseudomonas ubiquitously occur in natural environments and are two of the most intensively studied bacterial genera in the soil. They are often coisolated from environmental samples, and as a result, several studies have experi...
Advancing research on ectomycorrhizal fungal adaptation with landscape genomics [0.03%]
基于景观基因组学的外生菌根真菌适应性进化研究进展
Benjamin Dauphin,Martina Peter
Benjamin Dauphin
Ectomycorrhizal (ECM) fungi serve key functions in forest ecosystems by supplying water and nutrients to tree hosts, yet mutualistic plant-fungi interactions are jeopardised by environmental alterations. Here, we discuss the great potential...
The biosynthesis and role of phosphorylcholine in pathogenic and nonpathogenic bacteria [0.03%]
磷胆碱在致病菌和非致病菌中的生物合成及其作用
Yuan Zhang,Freda E-C Jen,Kate L Fox et al.
Yuan Zhang et al.
Phosphorylcholine (ChoP) can be found in all life forms. Although this molecule was first thought to be uncommon in bacteria, it is now appreciated that many bacteria express ChoP on their surface. ChoP is usually attached to a glycan struc...
Metallo-β-lactamase-mediated antimicrobial resistance and progress in inhibitor discovery [0.03%]
金属β-内酰胺酶介导的抗菌药物耐药性及抑制剂研究进展
Yongqiang Yang,Yu-Hang Yan,Christopher J Schofield et al.
Yongqiang Yang et al.
Resistance to β-lactam antibiotics is rapidly growing, substantially due to the spread of serine-β-lactamases (SBLs) and metallo-β-lactamases (MBLs), which efficiently catalyse β-lactam hydrolysis. Combinations of a β-lactam antibiotic...
QseB/QseC: a two-component system globally regulating bacterial behaviors [0.03%]
QseB/QseC：一个全局调控细菌行为的双组分系统
Yuxiang Zhu,Qin Dou,Liangcheng Du et al.
Yuxiang Zhu et al.
QseB/QseC is a two-component system that is involved in the regulation of multiple bacterial behaviors by regulating quorum sensing, bacterial pathogenicity, and antibiotic resistance. Thus, QseB/QseC could provide a target for new antibiot...
Computational methods and challenges in analyzing intratumoral microbiome data [0.03%]
肿瘤微生物组数据分析的计算方法和挑战
Qi Wang,Zhaoqian Liu,Anjun Ma et al.
Qi Wang et al.
The human microbiome is intimately related to cancer biology and plays a vital role in the efficacy of cancer treatments, including immunotherapy. Extraordinary evidence has revealed that several microbes influence tumor development through...
Assigning cause for emerging diseases of aquatic organisms [0.03%]
assignable cause of emergent disease in aquatic organisms
Kate S Hutson,Ian C Davidson,Jerusha Bennett et al.
Kate S Hutson et al.
Resolving the cause of disease (= aetiology) in aquatic organisms is a challenging but essential goal, heightened by increasing disease prevalence in a changing climate and an interconnected world of anthropogenic pathogen spread. Emerging ...
Jorge L Mazza Rodrigues,Maeli Melotto
Jorge L Mazza Rodrigues
Nature-designed plant microbiomes may offer solutions to improve crop production and ecosystem restoration in less than optimum environments. Through a full exploration of metagenomic data, Camargo et al. showed that a previously unknown mi...
Arnaud Kengmo Tchoupa,Dorothee Kretschmer,Birgit Schittek et al.
Arnaud Kengmo Tchoupa et al.
The corneocyte layers forming the upper surface of mammalian skin are embedded in a lamellar-membrane matrix which repels harmful molecules while retaining solutes from subcutaneous tissues. Only certain bacterial and fungal taxa colonize s...