Paradigms for microbiome analysis in infectious and non-communicable diseases [0.03%]
传染病和非传染性疾病的微生物组研究范式
Ingo B Autenrieth,Laetitia Bury,Ashley M Rooney et al.
Ingo B Autenrieth et al.
Next-generation sequencing and bioinformatics paved the way in deciphering the human gut microbiome and challenged fundamental postulates on the causal role of the microbiota for health and pathogenesis of infectious and noncommunicable dis...
Powassan virus [0.03%]
波瓦桑病毒
Angélica Peña Rosado,Amelia K Pinto
Angélica Peña Rosado
Producing Trojans: hijacking of monocyte differentiation by pathogens [0.03%]
类风湿性关节炎中病原体对单核细胞分化的影响及其机制研究进展
Jawid Nazir Ahmad,Peter Sebo
Jawid Nazir Ahmad
Pathogens can exploit the plasticity of host immune cells, such as the pathway of monocyte differentiation into macrophages and dendritic cells. This review discusses how microbial pathogens hijack the monocyte fate and reprogram macrophage...
Alteromonas macleodii [0.03%]
麦氏交替单胞菌
Sydney Plummer,J Jeffrey Morris
Sydney Plummer
From global to local: rethinking the design of probiotic intervention strategies [0.03%]
从全球到局部：重新思考益生菌干预策略的设计
Pascale Vonaesch,Julian R Garneau,Maria Gloria Dominguez-Bello
Pascale Vonaesch
The human microbiome plays a crucial role in maintaining homeostasis and influencing disease development, yet its composition varies across geography, age, and lifestyle. These differences challenge the efficacy of universal probiotic treat...
Cellular and viral RNA polymerases: evolutionary insights into eukaryotic origins [0.03%]
细胞和病毒RNA聚合酶：对真核生物起源的进化见解
Kuan Yee Wong,Xiaoyuan Feng,Xiaojun Wang et al.
Kuan Yee Wong et al.
Nucleocytoplasmic large DNA viruses (NCLDVs) encode multi-subunit RNA polymerases (msRNAPs) that challenge conventional views of viral evolution. Phylogenetic and structural studies reveal that NCLDV RNAP catalytic cores share deep evolutio...
Opportunities and challenges in applying microbiota to clinical cancer immunotherapy [0.03%]
微生物组在临床肿瘤免疫治疗中应用的机遇与挑战
Dingjiacheng Jia,Liangjing Wang
Dingjiacheng Jia
Fundamental research has elucidated the indispensable role of gut microbiota in modulating cancer immunotherapy efficacy. Despite promising preclinical findings, few related approaches have reached clinical trials. In this opinion, we provi...
Kevin Yang,Aviram Rasouly,Evgeny Nudler
Kevin Yang
Antibiotic combination therapy has a critical role in limiting emergent antibiotic resistance in bacterial pathogens. Collateral sensitivity (CS), resistance to one antibiotic that is inextricable from sensitivity to another antibiotic, pre...
John Klironomos,Junling Zhang,Guangzhou Wang
John Klironomos
Johnson and Marín's paper presents functional team selection (FTS) as a major conceptual advance in plant-microbiome ecology. FTS explains how limiting resources and/or stress selects cooperative microbial teams that promote plant adaptati...
Caden W Munson,Deepak Kaushal
Caden W Munson
Mycobacterium tuberculosis (Mtb) remains an epidemiological concern due to heterogeneous outcomes in tuberculosis (TB) pathology and the lack of mechanistic understanding of early immune events. Type I interferons (IFNs) in TB are generally...