Exploiting cAMP signaling in Mycobacterium tuberculosis for drug discovery [0.03%]
挖掘结核分枝杆菌中的cAMP信号通路以用于药物发现
Dipak Kathayat,Brian C VanderVen
Dipak Kathayat
Mycobacterium tuberculosis (Mtb) replicates within host macrophages by adapting to the stressful and nutritionally constrained environments in these cells. Exploiting these adaptations for drug discovery has revealed that perturbing cAMP si...
Dmitry A Filatov,Mark Kirkpatrick
Dmitry A Filatov
Marine phytoplankton play crucial roles in the Earth's ecological, chemical, and geological processes. They are responsible for about half of global primary production and drive the ocean biological carbon pump. Understanding how plankton s...
Ying-Qi Lu,Han Qiao,Xi-Rong Tan et al.
Ying-Qi Lu et al.
The microbiota of solid tumors was identified >100 years ago; however, heterogeneous composition and diversity have been revealed only recently. Growing evidence has suggested that several functional mechanisms of the intratumoral microbiot...
Sergio A Muñoz-Gómez
Sergio A Muñoz-Gómez
The evolutionary history of cells has been marked by drastic increases in complexity. Some hypothesize that such cellular complexification requires a massive energy flux as the origin of new features is hypothetically more energetically cos...
Chemosynthesis: a neglected foundation of marine ecology and biogeochemistry [0.03%]
化能合成作用：被忽视的海洋生态学和生物地球化学基础
Francesco Ricci,Chris Greening
Francesco Ricci
Chemosynthesis is a metabolic process that transfers carbon to the biosphere using reduced compounds. It is well recognised that chemosynthesis occurs in much of the ocean, but it is often thought to be a negligible process compared to phot...
Chuwen Zhang,Yongyi Peng,Xinyue Liu et al.
Chuwen Zhang et al.
Deep-sea ecosystems are home to a diverse community of microorganisms. These microbes are not only fundamental to ecological processes but also a treasure trove of natural products and enzymes with significant scientific and industrial appl...
Subham Mridha,Michael C Abt
Subham Mridha
Iron is an essential nutrient for bacterial pathogenesis. In their study, Skaar and colleagues (Pi et al.) discovered and determined the detailed structure of ferrosomes within Clostridioides difficile, the iron-storage organelles that form...
Katarzyna Bialas,Felipe Diaz-Griffero
Katarzyna Bialas
Cleavage and polyadenylation specificity factor subunit 6 (CPSF6, also known as CFIm68) is a 68 kDa component of the mammalian cleavage factor I (CFIm) complex that modulates mRNA alternative polyadenylation (APA) and determines 3' untransl...
Breaking bad nucleotides: understanding the regulatory mechanisms of bacterial small alarmone hydrolases [0.03%]
破坏不良核苷酸：理解细菌小型报警激素水解酶的调控机制
Adriana Chrenková,Francesco Bisiak,Ditlev E Brodersen
Adriana Chrenková
Guanosine tetra- and pentaphosphate nucleotides, (p)ppGpp, function as central secondary messengers and alarmones in bacterial cell biology, signalling a range of stress conditions, including nutrient starvation and exposure to cell-wall-ta...
Projecting global biological N2 fixation under climate warming across land and ocean [0.03%]
气候变暖背景下陆地和海洋的全球生物固氮预测
Curtis Deutsch,Keisuke Inomura,Ya-Wei Luo et al.
Curtis Deutsch et al.
Biological N2 fixation sustains the global inventory of nitrogenous nutrients essential for the productivity of terrestrial and marine ecosystems. Like most metabolic processes, rates of biological N2 fixation vary strongly with temperature...