TldR: TnpB's evolutionary shift from transposon nucleases to RNA-guided transcriptional regulators [0.03%]
TldR：TnpB的进化转变——从转座酶核酸酶到RNA引导的转录调节因子
Prarthana Mohanraju,Wen Y Wu
Prarthana Mohanraju
TnpB proteins are transposon-encoded nucleases involved in transposon DNA propagation. Wiegand et al. identified a new class of TnpB-derived proteins, called TnpB-like nuclease-dead repressors (TldRs), which function as RNA-guided transcrip...
Environmental microbiome, human fungal pathogens, and antimicrobial resistance [0.03%]
环境微生物组、人类真菌病原体和抗菌药物耐药性
Zhen-Zhen Yan,Hang-Wei Hu,Chao Xiong et al.
Zhen-Zhen Yan et al.
Traditionally, antifungal resistance (AFR) has received much less attention compared with bacterial resistance to antibiotics. However, global changes, pandemics, and emerging new fungal infections have highlighted global health consequence...
The conserved AvrE family of bacterial effectors: functions and targets during pathogenesis [0.03%]
保守的细菌效应子AvrE家族：其在致病过程中的功能及作用对象
Laura Herold,Sera Choi,Sheng Yang He et al.
Laura Herold et al.
The AvrE family of type III secreted effectors are highly conserved among many agriculturally important phytopathogenic bacteria. Despite their critical roles in the pathogenesis of phytopathogenic bacteria, the molecular functions and viru...
Charlotte Kamm,Chase L Beisel
Charlotte Kamm
The gut microbiome contains numerous bacteria tied to our health. However, genetically modifying this community remains a major challenge. Brödel et al. take a critical step by engineering bacteriophages to efficiently deliver gene editors...
Bioinformatics challenges for profiling the microbiome in cancer: pitfalls and opportunities [0.03%]
癌症中描绘微生物组的生物信息学挑战：陷阱与机遇
Nicholas A Bokulich,Michael S Robeson nd
Nicholas A Bokulich
Increasing evidence suggests that the human microbiome plays an important role in cancer risk and treatment. Untargeted 'omics' techniques have accelerated research into microbiome-cancer interactions, supporting the discovery of novel asso...
Akkermansia muciniphila [0.03%]
阿克曼氏菌黏液噬菌体
Cindy Menjivar,Emma Pagella,Indranil Biswas
Cindy Menjivar
The role of cyclic nucleotides in bacterial antimicrobial resistance and tolerance [0.03%]
环核苷酸在细菌抗微生物耐药性和忍耐性中的作用
Yi Liu,Claudia Blanco-Toral,Gerald Larrouy-Maumus
Yi Liu
Nucleotide signalling molecules - mainly cyclic 3',5'-adenosine phosphate (cAMP), bis-(3',5')-cyclic diguanosine monophosphate (c-di-GMP), and bis-(3',5')-cyclic diadenosine monophosphate (c-di-AMP) - contribute to the regulation of cellula...
Gui Araujo,José M Montoya,Torsten Thomas et al.
Gui Araujo et al.
Virtually all multicellular organisms on Earth live in symbiotic associations with complex microbial communities: the microbiome. This ancient relationship is of fundamental importance for both the host and the microbiome. Recently, the ana...
Jingyi Zhang,Heng Sun,Feng Feng et al.
Jingyi Zhang et al.
Nematodes do not merely siphon off plant resources but also sabotage the plant's mutualistic relationships with beneficial microbes. Yang and colleagues elegantly elucidated this generalizable molecular antagonism, revealing how Heterodera ...
Qing-Lin Chen,Kai Yang,Qian Xiang et al.
Qing-Lin Chen et al.
Conventional bulk molecular approaches, often limited by their destructive nature and low spatial resolution, face challenges when probing the intricate dynamics of the plastisphere. Here, we outline a framework employing Raman spectroscopy...