.Clostridioides difficile [0.03%]
难辨梭菌
Brindar K Sandhu,Shonna M McBride
Brindar K Sandhu
Clostridioides difficile is a spore-forming, anaerobic, intestinal pathogen that causes severe diarrhea that can lead to death. In 2011, C. difficile infected ∼500000 people in the USA and killed ∼29000 people. C. difficile infection (CDI...
Alexis J Bick,Janet P Hapgood
Alexis J Bick
Persistence of the latent reservoir remains a challenge to curing HIV infection. Using shRNA screening, new insights into the molecular mechanisms underlying latency regulation indicate that the estrogen receptor is a potent repressor of pr...
Luis L P daSilva,Gonzalo A Mardones
Luis L P daSilva
Nef is a major pathogenic factor of human and simian immunodeficiency viruses that hijacks protein trafficking through physical interaction with vesicle coats. This alters the subcellular localization of proteins involved in immunity and ne...
One for All, but Not All for One: Social Behavior during Bacterial Diseases [0.03%]
有损亦共享：细菌感染过程中的社会行为
Kimberly M Davis,Ralph R Isberg
Kimberly M Davis
It has been known for decades that individual cells within pathogenic bacterial populations have reduced antibiotic susceptibility, which is linked to decreased metabolic rates. A similar phenomenon occurs with virulence-associated proteins...
Nandhini Saranathan,Perumal Vivekanandan
Nandhini Saranathan
G-quadruplexes (G4s) are noncanonical nucleic acid secondary structures formed by guanine-rich DNA and RNA sequences. In this review we aim to provide an overview of the biological roles of G4s in microbial genomes with emphasis on recent d...
Shumpei Watanabe,Yuta Shirogane,Yuma Sato et al.
Shumpei Watanabe et al.
Measles virus (MeV) may persist in the brain, causing fatal neurodegenerative diseases, subacute sclerosing panencephalitis, and measles inclusion-body encephalitis. However, the mechanism of MeV propagation in the brain remains unexplained...
Hanne L P Tytgat,Franklin L Nobrega,John van der Oost et al.
Hanne L P Tytgat et al.
Bacterial communities are known to impact human health and disease. Mixed species biofilms, mostly pathogenic in nature, have been observed in dental and gastric infections as well as in intestinal diseases, chronic gut wounds and colon can...
Antonio Gregorio Dias Junior,Natalia G Sampaio,Jan Rehwinkel
Antonio Gregorio Dias Junior
Induction of interferons during viral infection is mediated by cellular proteins that recognise viral nucleic acids. MDA5 is one such sensor of virus presence and is activated by RNA. MDA5 is required for immunity against several classes of...
Can Ebola Virus Vaccines Have Universal Immune Correlates of protection? [0.03%]
埃博拉病毒疫苗能具有免疫保护相关性指标吗？
Michelle Meyer,Delphine C Malherbe,Alexander Bukreyev
Michelle Meyer
Testing vaccine efficacy against the highly lethal Ebola virus (EBOV) in humans is almost impossible due to obvious ethical reasons and the sporadic nature of outbreaks. For such situations, the 'animal rule' was established, requiring the ...
From Theory to Practice: Translating Whole-Genome Sequencing (WGS) into the Clinic [0.03%]
从理论到实践：将全基因组测序（WGS）应用于临床
Francois Balloux,Ola Brønstad Brynildsrud,Lucy van Dorp et al.
Francois Balloux et al.
Hospitals worldwide are facing an increasing incidence of hard-to-treat infections. Limiting infections and providing patients with optimal drug regimens require timely strain identification as well as virulence and drug-resistance profilin...