Energy metabolic failure drives the selective degeneration of dopaminergic neurons in Parkinson's disease [0.03%]
代谢衰竭驱动帕金森病多巴胺能神经元的选择性退变
Zhipeng Zhou
Zhipeng Zhou
Parkinson's disease (PD) is the fastest growing neurodegenerative disorder worldwide. A critical barrier to therapeutic development is the incomplete understanding of mechanisms driving the selective degeneration of substantia nigra pars co...
Bimanual isometric force control impairments in patients with Parkinson's disease [0.03%]
帕金森病患者的双侧等长力量控制异常现象
Hanall Lee,Kyeongho Byun,Kiwon Park et al.
Hanall Lee et al.
Background: Patients with Parkinson's disease in the early stage show mild onset of motor symptoms that may affect negatively on bimanual force control and interlimb coordination. This current study investigated bimanual ...
Static and dynamic alterations of local brain activity in schizophrenia and associations with clinical symptoms and cognitive function [0.03%]
精神分裂症患者局部脑活动的静态和动态改变及其与临床症状和认知功能的关系
Shuzhe Wang,Peiwen Ren,Chenghao Lu et al.
Shuzhe Wang et al.
Background and hypothesis: Most neuroimaging studies in schizophrenia (SCZ) focus on static brain activity, with limited attention to its temporal dynamics. We hypothesized that integrating static and dynamic measures of ...
Left-to-right dorsomedial prefrontal cortex interhemispheric projections mediate psychosocial stress vulnerability [0.03%]
从左侧到右侧的背侧前额叶皮层半球间投射介导心理社会压力易感性
Gessynger Morais-Silva,Beatriz Fagundes Gasques,Isabelle Lima Lugli et al.
Gessynger Morais-Silva et al.
Functional asymmetries in the medial prefrontal cortex (mPFC) are significant attributes of this brain area, implicated in its role in emotional processing and executive function. Evidence suggests that, under normal conditions, there is a ...
Yujie Long,Ping Yao,Guangyuan Zou et al.
Yujie Long et al.
Insomnia disorder (ID) is prevalent and debilitating, yet its neurophysiological basis remains unclear. Abnormalities in temporal parameters of electroencephalography (EEG) microstates have been linked to diverse neuropsychiatric disorders,...
The RBFOX1 regulatory gene network contributes to major depressive disorder, anxiety, irritability and neuroticism [0.03%]
RBFOX1调控基因网络参与抑郁症、焦虑症、易怒和神经质的发病机制
Maja R Adel,Ester Antón-Galindo,Florian Freudenberg et al.
Maja R Adel et al.
Major depressive disorder (MDD) is a complex psychiatric disorder frequently comorbid with anxiety disorders, suicide attempts, and personality traits such as irritability and neuroticism. RBFOX1, which encodes a splicing factor, is a known...
Sex-dependent endocrine, cardiovascular, nociceptive and behavioral responses in rats cohabitating with a conspecific in chronic neuropathic pain [0.03%]
共患病大鼠与同种群成员共同居住时的性别依赖性内分泌、心血管、痛觉和行为反应
Vinicius Pelarin,Lígia R R Tavares,Lilian L Reis-Silva et al.
Vinicius Pelarin et al.
This study aimed to characterize the effects of cohabitation with a same-sex conspecific experiencing chronic neuropathic pain on anxiety-like behavior, mechanical nociception, and both basal and stress-reactive levels of corticosterone, ar...
Serotonergic psychedelics for Autism spectrum disorder: Neurobiological mechanisms and translational prospects [0.03%]
血清素能迷幻剂在自闭症谱系障碍中的神经生物学机制和转化前景
Zhen Xuen Brandon Low
Zhen Xuen Brandon Low
Autism Spectrum Disorder (ASD) is characterized by persistent social-communication deficits, cognitive rigidity, and atypical sensory processing. Current pharmacological treatments, including risperidone and aripiprazole, provide only limit...
Neural correlates of late talking: A systematic review of electrophysiological and neuroimaging studies [0.03%]
有关说话迟缓的神经相关性：一项系统性的脑电和神经影像学研究回顾
Mohammad Reza Mohammadi,Hooshang Dadgar,Shahab Alaedin Baloochi et al.
Mohammad Reza Mohammadi et al.
Background: Late talking (LT), a delay in expressive vocabulary in early childhood, affects a significant minority of toddlers and can be a precursor to persistent language and literacy impairments. While behavioral profi...
The impact of perinatal opioid exposure on neuronal and glial cell development: A consideration of prenatal versus postnatal exposure in animal models [0.03%]
围产期阿片暴露对神经元和胶质细胞发育的影响：动物模型中宫内与出生后暴露的比较
Rinjani Soengkoeng,Kelly J Clemens
Rinjani Soengkoeng
Prenatal opioid exposure (POE) is associated with abnormal brain structure and functioning in affected individuals, underscoring a need for preclinical models to discover the neuro-molecular origins of such deficits. Rodent models can recre...