Linking macro-scale structural-functional networks to micro-scale neurotransmitter architectures in first-episode, drug-naïve OCD [0.03%]
首发、未用药OCD患者五羟色胺大型功能连接与小型神经递质结构的关联研究
Zihan Li,Xiaopan Zhang,Jin Sun et al.
Zihan Li et al.
We investigated the multimodal neuroimaging alterations and their neurochemical underpinnings in obsessive-compulsive disorder (OCD). Structural and resting-state functional MRI (rs-fMRI) data were collected from 61 first-episode, medicatio...
Clinical and quality of life predictors in patients with schizophrenia with and without substance use disorder [0.03%]
精神分裂症伴或不伴有物质使用障碍患者的临床和生活质量预测因素
Álvaro González-Sánchez,José Francisco Navarro,Erika Y Bedoya et al.
Álvaro González-Sánchez et al.
The comorbidity of schizophrenia (SZ) and substance use disorder (SUD), also known as dual schizophrenia (SZ+), represents a clinical challenge due to its high prevalence and impact on prognosis and quality of life. However, evidence of its...
Comparative network pharmacology analysis of ketamine and xanomeline in major depressive disorder: Shared and distinct molecular mechanisms [0.03%]
氯胺酮和氙诺明在抑郁症中分子机制的比较网络药理学分析：相同点与不同点
Xin Ding,Kenji Hashimoto,Jian-Jun Yang
Xin Ding
Major depressive disorder (MDD) is a leading cause of disability worldwide, and currently available antidepressants remain limited by delayed onset of action, incomplete response, and adverse effects. Ketamine is a rapid-acting antidepressa...
Astrocytic extracellular matrix proteins in ADHD: The role of thrombospondin-1, sparc, and sparcl-1 [0.03%]
ADHD中的星形胶质细胞外基质蛋白：血小板反应蛋白-1、酸性神经鞘蛋白和唾液酸化的星形胶质细胞蛋白质的调节因子的作用
Nilüfer Yıldız Kısmet,Selen Sezen Gökçearslan,Serenay Elgün Ülkar et al.
Nilüfer Yıldız Kısmet et al.
Astrocyte-derived extracellular matrix (ECM) proteins are critical for synaptic development and glutamatergic signaling, yet their role in attention deficit hyperactivity disorder (ADHD) remains poorly understood. This study examined serum ...
Brain state dynamics and working memory in patients with major depressive disorder and bipolar disorder [0.03%]
抑郁症及双相情感障碍患者的脑动力学和工作记忆
Feiwen Wang,Zhening Liu,Danqing Huang et al.
Feiwen Wang et al.
Background: Working memory (WM) deficits are common in major depressive disorder (MDD) and bipolar disorder (BD) and may reflect disrupted transitions between latent brain states during cognitive engagement. Using a robus...
Structural brain network alterations in schizophrenia and ultra-high risk populations: Linking olfactory dysfunction to clinical symptoms [0.03%]
精神分裂症和高危人群的脑结构网络改变：嗅觉功能障碍与临床症状的关系
Huiqing Peng,Ying He,Xiaogang Chen et al.
Huiqing Peng et al.
Background: Olfactory dysfunction is an early feature of schizophrenia, but its structural brain network basis remains unclear, especially in ultra-high risk (UHR) individuals. ...
Cognition in the time of dysbiosis: Sleep disruption and the gut-brain dialogue [0.03%]
肠道菌群失调时期的认知：睡眠紊乱与肠-脑对话
Monica L Andersen,Tathiana A Alvarenga,Sergio Tufik
Monica L Andersen
The gut microbiota plays an important role in the regulation of physiological and behavioral functions, including cognition. Growing evidence suggests that alterations in microbial composition can disrupt memory processes, in part through b...
Deep brain stimulation: A narrative review of its applicability for major depressive disorder [0.03%]
深部脑刺激治疗难治性抑郁症的研究进展及临床应用挑战：叙述性综述
Sandra S Meirelles,Lucas C Pedro,Karla F Zocatelli et al.
Sandra S Meirelles et al.
Objectives: This article reviews the existing literature on DBS in the context of MDD, with particular attention to treatment-resistant depression (TRD), and provides a comprehensive, up-to-date overview of its mechanisms...
Therapeutic effects of TRPC4/5 antagonism in a rat model of bipolar disorder [0.03%]
针对双相情感障碍大鼠模型的TRPC4/5拮抗剂治疗效应研究
Bahadır Demir,Sena Çevik,Saadet Bekerecioğlu et al.
Bahadır Demir et al.
Bipolar disorder, a chronic neuropsychiatric condition, is characterized by alternating episodes of mania and depression. Although acute manic episodes have become increasingly manageable with the advent of third-generation neuroleptics, th...
Aberrant effective connectivity in gray matter volume-altered brain regions in males with tobacco use disorder: A multimodal study combining meta-analysis and spectral DCM [0.03%]
结合多模态meta分析和谱DCM在烟草使用障碍男性患者灰质体积改变脑区的有效连接异常研究
Guohao Lu,Yichen Guo,Longyao Ma et al.
Guohao Lu et al.
Background and objective: Tobacco use disorder (TUD) is associated with widespread structural alterations and functional dysregulation in the brain. However, the dynamic causal interactions among structurally abnormal reg...