The influence of the estrous cycle in preclinical models that mimic key features of post-traumatic stress disorder: A systematic review [0.03%]
模拟创伤后应激障碍关键特征的临床前模型中月经周期的影响：系统评价
Eliza McCann,Thiago H Almeida-Souza,Paula N Brandão-Lima et al.
Eliza McCann et al.
Similar to other mood and anxiety conditions, post-traumatic stress disorder (PTSD) appears to be more prevalent and have a more protracted course in females. In the clinic, PTSD symptoms have been shown to worsen during phases of the menst...
Cell-type-specific gene regulation in migraine and its subtypes links genetic risk to brain structure [0.03%]
与偏头痛及其亚型特异性基因调控相关的遗传风险和大脑结构之间的联系
Haoyang Dong,Mengge Liu,Qian Wu et al.
Haoyang Dong et al.
Migraine is a highly prevalent and disabling neurological disorder characterized by marked clinical heterogeneity, particularly between migraine with aura (MA) and migraine without aura (MO). Although genome-wide association studies (GWASs)...
Elevated medial prefrontal GABA/Glx ratio in preschool autistic children: A 1H-MRS study of cognitive and behavioral correlates [0.03%]
学龄前儿童自闭症中GABA/Glx水平升高的研究：一种认知和行为关联的1H-MRS研究方法
Tianyi Zhao,Pu Tian,Zhuohang Liu et al.
Tianyi Zhao et al.
Background: The excitation/inhibition (E/I) imbalance theory posits that altered GABAergic signaling underlies the pathophysiology of autism. However, findings regarding GABA levels in early childhood remain inconsistent....
Roles of cytoskeleton-associated genes in radial migration and ASD during mouse neocortex development [0.03%]
小胶质细胞活化在精神分裂症和双相情感障碍中的性别差异及其相关遗传风险变异的影响研究
Xiaomei He,Mei Liu
Xiaomei He
In mammals, the neocortex consists of six distinct neuronal layers, each with specialized morphology and functions. Neuronal migration plays a pivotal role in the development of functional neural circuits. The migrating neurons primarily in...
NMDA receptor subtype differential affinity as a key enabler for precision neuropsychiatry [0.03%]
N-甲基-D-天冬氨酸 (NMDA) 受体亚型亲和力差异是精准神经精神病学的关键因素
Aline Freyssin,Reina Benabou,Hanna Zoe Müller et al.
Aline Freyssin et al.
Despite recent advances in neuropsychiatry, translational development for many targets remains challenging, particularly when receptors exist as families with complex subunit-dependent pharmacology and safety concerns. This is the case for ...
Decision-making impairments according to history of suicide attempt in depression: A computational model analysis [0.03%]
基于抑郁症患者自杀史的决策损伤的计算模型分析
R M Moret,A Alacreu-Crespo,F Molins et al.
R M Moret et al.
Background: It is well-established that individuals who have attempted suicide present decision-making impairments. However, the underlying constructs that constitute decision-making are still being explored. ...
Multi-level pathways linking personality and mood to problematic smartphone use: A behavioral and neuroimaging study [0.03%]
个性与情绪影响智能手机成瘾的多水平路径：行为和神经影像学研究
Xiang Li,Jinlian Wang,Hanbing Li et al.
Xiang Li et al.
Problematic smartphone use (PSU) is shaped by personality traits and emotional states, yet its neural and molecular underpinnings remain unclear. Guided by the I-PACE model, we combined behavioral assessment, task-based fMRI, and whole-brai...
Stanley Lyndon
Stanley Lyndon
Despite being the mainstay of treatment for major depressive disorder (MDD), antidepressants have highly variable efficacy, with fewer than a third of patients achieving remission after a first-line trial. This has fuelled a decades-long se...
Meta-analysis of blood metabolomics reveals dysregulated amino acid, neurotransmitter, and energy pathways in depression [0.03%]
血代谢组学的荟萃分析揭示了抑郁症中氨基酸、神经递质和能量途径的失调
Aleksandra Panina,Aleksandr V Sokolov,Mikhail M Khandokhin et al.
Aleksandra Panina et al.
Background: Depression is a major psychiatric illness with a global burden, poor treatment response, and limited biological markers, leaving diagnosis reliant on behavioral rather than biological methods. While there is a...
The cooccurrence of psychosis and emergent cognitive impairment/decline in rare genetic disorders: A scoping review [0.03%]
罕见遗传病中精神病和认知功能并发障碍/下降的共现：一项范围综述
Mark A Colijn
Mark A Colijn
Objective: Cognitive impairment is a core feature of schizophrenia, and psychosis can occur in numerous types of dementia. Although rare genetic variation may underlie the development of psychosis or dementia in some indi...