Dynamic neural trajectories of emotion bias processing in treatment-resistant depression: A novel perspective and computational approach [0.03%]
治疗抵抗性抑郁情绪偏差处理的动态神经轨迹：一个新的视角和计算方法
Weizhuang Kong,Zhe Sun,Wenhao Zhang et al.
Weizhuang Kong et al.
Emotional bias processing may serve as a core underpinning of the onset and persistence of treatment-resistant depression (TRD). However, its neural mechanisms remain unclear. A comprehensive understanding of the mechanisms requires elucida...
Metformin attenuates propylthiouracil-induced depressive-like behavior in rats: Involvement of AMPK-BDNF-PI3K Signaling and hippocampal redox homeostasis [0.03%]
二甲双胍通过AMPK-BDNF-PI3K信号传导和海马红氧化物稳态参与丙硫氧嘧啶诱导的大鼠抑郁样行为的缓解作用
Dalia G Elsayed,Eman M Sweed,Asmaa Sh Mohammed et al.
Dalia G Elsayed et al.
Background: Hypothyroidism is frequently associated with depressive disorders that are often refractory to conventional antidepressant therapy. Disruption of brain energy metabolism, neurotrophic signaling, and redox home...
Lipid dysregulation is associated with anxiety symptoms and left frontopolar cortical network alterations in overt hypothyroidism [0.03%]
脂质失调与显性甲状腺功能减退症的焦虑症状和左前顶叶皮层网络改变有关
Jiancang Cao,Quan Zou,Xingqi Liu et al.
Jiancang Cao et al.
Purpose: Neuropsychiatric symptoms persist in overt hypothyroidism (OH) despite hormone replacement. This study examined whether cortical morphometric similarity network alterations are associated with lipid dysregulation...
Cajanine protects against menopausal mood disorders and concomitant metabolic dysfunctions in ovariectomized mice via ERβ-mediated pathways [0.03%]
Cajanine通过ERβ介导的途径保护卵巢切除小鼠免受更年期情绪障碍和并发代谢功能障碍的影响
Qizhi Yan,Fan Wu,Pengtao Xu et al.
Qizhi Yan et al.
Menopausal mood disorders (MMD) are common neuropsychiatric symptoms in postmenopausal women, often accompanied by metabolic dysfunctions. This study aimed to investigate the therapeutic effect of cajanine on MMD and its underlying mechanis...
Clozapine and obsessive-compulsive symptoms: Integrating clinical outcomes, mechanisms, and precision psychiatry approaches [0.03%]
氯氮平与强迫症状：整合临床结果、机制和精准精神病学方法
Gamze Gürcan,Ravza Zeynep Sılay
Gamze Gürcan
Clozapine remains the gold-standard treatment for treatment-resistant schizophrenia owing to its superior antipsychotic efficacy and anti-suicidal properties, yet it is frequently associated with the emergence of obsessive-compulsive sympto...
Beyond categorical boundaries: Common molecular and cellular pathways in autism spectrum disorder and schizophrenia [0.03%]
超越分类界限自闭症光谱障碍和精神分裂症的分子和细胞通路的共性
Nahi Sabih Alruwaili,Hayder M Al-Kuraishy,Ali I Al-Gareeb et al.
Nahi Sabih Alruwaili et al.
Historically, ASD and schizophrenia have been classified as two distinct disorders, one being a neurodevelopmental disorder and the other a psychotic disorder. Recent studies, however, suggest that there may be substantial overlap between t...
The interplay between microbiota and the gut-brain axis in treatment-resistant depression [0.03%]
微生态系统和肠-脑轴在难治性抑郁治疗中的相互作用
Amanda Gollo Bertollo,Camila Ferreira Puntel,Giselli Scaini et al.
Amanda Gollo Bertollo et al.
Major depressive disorder (MDD) is a common psychiatric condition, and many patients do not respond to standard antidepressant treatments, developing what is known as treatment-resistant depression (TRD). The microbiota-gut-brain axis (MGBA...
Elevated serum glycogen synthase kinase-3β and brain-derived neurotrophic factor in pediatric obsessive-compulsive disorder [0.03%]
儿童强迫症患者血清糖原合成酶激酶-3β和脑源性神经营养因子水平升高
Hatice Alarslan,E Yildirim Demirdogen,M Akif Akinci et al.
Hatice Alarslan et al.
Objectives: Obsessive-compulsive disorder (OCD) is a multifactorial condition in which inflammation is increasingly implicated. The WNT/β-catenin signaling pathway, involved in inflammatory regulation and circadian mecha...
Canagliflozin attenuates cognitive deficits in the streptozotocin-induced mouse model of sporadic Alzheimer's disease via modulating PINK1/Parkin signaling pathway and miR-34a expression [0.03%]
卡格列净通过调节PINK1/Parkin信号通路和miR-34a表达缓解链脲佐菌素诱导的小鼠散发型阿尔茨海默病认知缺陷
Rania I Nadeem,Rabab H Sayed,Eman M Elbaz et al.
Rania I Nadeem et al.
Mitochondrial deficits and impairments in mitophagy, a specialized form of mitochondrial degradation by autophagy, contribute to Alzheimer's disease (AD). Furthermore, dysregulated miR-34a was reported to contribute to AD progression. Sodiu...
Fara Tabrizi,Hampus Grönvall,Sylvia Adbelhalim et al.
Fara Tabrizi et al.
Acute psychological stress triggers rapid physiological adjustments, but the full scope of associated metabolic changes in humans remains poorly characterized. Prior studies have typically examined a limited set of candidate metabolites or ...