Novel genetic insights into causal effects of depression on non-alcoholic fatty liver diseases partially mediated by gut microbiota [0.03%]
肠道微生物介导的抑郁症对非酒精性脂肪肝疾病影响的病因作用的新遗传见解
Yong Pan,Yujing Wang,Yi Liu et al.
Yong Pan et al.
Depression and non-alcoholic fatty liver disease (NAFLD) are increasingly recognized as interconnected disorders, yet the causal mechanisms linking them remain unclear. Using univariable and multivariable Mendelian randomization (MR), we de...
The role of genetic variants and iron homeostasis in antipsychotic-induced akathisia: A systematic review and meta-analysis [0.03%]
抗精神病药物引起的不安腿综合征的遗传变异和铁稳态的作用：系统评价和meta分析
Ahmadreza Ahmadi,Mohammad Hossein Salimian,Faeze Mansouri et al.
Ahmadreza Ahmadi et al.
Background: Antipsychotic-induced akathisia (AIA) is a common and highly distressing adverse drug reaction that significantly impacts treatment adherence and quality of life. The considerable interindividual variability i...
Mutations in the three synapsin genes lead to profound social deficits and cortical dysfunctions [0.03%]
三种突触蛋白基因的突变会导致严重的社交缺陷和皮层功能障碍
Noemi Nicosia,Elena Monzani,Maria Regoni et al.
Noemi Nicosia et al.
Synapsins are presynaptic proteins that regulate synaptic vesicle trafficking and neurotransmitter release. Mutations in synapsin genes are associated with epilepsy, autism spectrum disorders, and other neurodevelopmental conditions. Syn1/S...
Emerging cell death in depression: Mechanisms and therapeutic implications [0.03%]
抑郁症中的新兴细胞死亡机制及其治疗意义
Chuang Jin,Yuhui Li
Chuang Jin
Major depressive disorder (MDD) is a highly prevalent psychiatric condition and a leading cause of disability worldwide. Despite extensive research, incomplete elucidation of its underlying pathological and pharmacological mechanisms contin...
GLP-1 receptor agonism reduces PTSD-like anxiety and alters amygdala-hippocampal activity patterns in a Chemogenetic mouse model [0.03%]
GLP-1受体激动剂减少PTSD样焦虑并改变化学遗传小鼠模型中的杏仁核-海马神经元活动模式
Kubra Akillioglu,Seda Kose Korkmaz,Meltem Donmez Kutlu et al.
Kubra Akillioglu et al.
Dysregulated glutamatergic transmission within amygdala-hippocampal circuits has been implicated in the pathophysiology of post-traumatic stress disorder (PTSD), yet pharmacological approaches targeting stress-related behavioral and molecul...
Morphine self-administration is associated with cerebellar remodeling, altered cerebello-cerebral connectivity, and changes in navigational organization in male Wistar rats [0.03%]
吗啡自我给药与雄性Wistar大鼠小脑重塑、脑-脑连接改变及导航组织变化有关
Mariana Stefania Serrano-Ramírez,Jalil Rasgado-Toledo,David Medina-Sánchez et al.
Mariana Stefania Serrano-Ramírez et al.
Opioid addiction is characterized by a strong motivational drive to obtain the drug, traditionally attributed to neuroadaptations within mesocorticolimbic reward circuits. Increasing evidence suggests that opioid-induced plasticity extends ...
Gut Microbiota from GAD patients with divergent early pharmacological responses transmits anxiety-like behaviors and distinct metabolic profiles in recipient mice [0.03%]
不同早期药理反应的GAD患者肠道微生物组在受体小鼠中传递类似焦虑的行为和不同的代谢谱型
Hong He,Li-Zhi Liu,Hui-Feng Duan et al.
Hong He et al.
The gut microbiota is implicated in the pathogenesis of generalized anxiety disorder (GAD), but whether microbial differences between GAD patients with remission (R-GAD) and those with poor early treatment response (P-GAD) causally contribu...
Shared genetic architecture of Parkinson's disease and cutaneous melanoma: Heterogeneous pleiotropy and Colocalization at the SOX6 locus [0.03%]
帕金森病和皮肤黑色素瘤共有的遗传基础：SOX6位点的异质多效性和等位基因定位共存现象
Caihong Li,Andreas Baur,Lingfeng Pan
Caihong Li
Parkinson's disease (PD) and cutaneous melanoma show epidemiological co-occurrence, but their shared genetic architecture remains unclear METHODS: We combined bidirectional time-dependent cox regression in the UK biobank (N ≈ 500,000) with...
Minkyung Park,So Young Yoo,Joon Hwan Jang et al.
Minkyung Park et al.
Aberrant resting-state functional connectivity (rsFC) within neurocognitive networks is a hallmark of alcohol use disorder (AUD). However, the spatial architecture of the central autonomic network (CAN)-the vital neural substrate governing ...
A causal inference framework to bridge association and mechanism in the gut-brain axis [0.03%]
一种因果推理框架：弥合肠道-大脑轴关联与机制之间的差距
Hevar N Barznji
Hevar N Barznji
The gut-brain axis represents a major paradigm shift in how we evaluate diseases in neuroscience, with microbial dysbiosis affecting many neurological and psychiatric disorders. However, the clinical translation of these findings into effec...