Tumor-antigen-independent targeting of solid tumors by armored macrophage-directed anti-TREM2 CAR T cells [0.03%]
装甲巨噬细胞引导的抗 TREM2 单克隆抗体 T 细胞对实体瘤的非肿瘤抗原依赖性靶向作用
Gal Yagel,Dana Rimini,Michelle von Locquenghien et al.
Gal Yagel et al.
Chimeric antigen receptor (CAR) T cell therapy has shown remarkable success in hematologic malignancies and autoimmune diseases but remains limited in solid tumors due to antigen heterogeneity, escape, and an immunosuppressive tumor microen...
Boya Wang,George Wright,Julius C Enssle et al.
Boya Wang et al.
Genetic and gene expression subtypes of diffuse large B cell lymphoma (DLBCL) have been defined using bulk tumor analysis. To explore their biology, we derived single-cell RNA and ATAC sequencing data from 103 DLBCL biopsies and identified ...
Single-cell screens identify ADAM12 as a fibroblast checkpoint impeding anti-tumor immunity [0.03%]
单细胞筛选识别出ADAM12作为阻碍抗肿瘤免疫的成纤维细胞检查点
Jianan Li,Huilan Liu,Qile Guo et al.
Jianan Li et al.
Clinical trials targeting cancer-associated fibroblasts (CAFs)-crucial pro-tumoral factors in cancer-have almost all failed. This may be ascribed to their intrinsic functional plasticity and the opaque regulatory circuits underlying their h...
Multiomic integration reveals tumoral heterogeneity of lipid dependence within lethal group 3 medulloblastoma [0.03%]
多组学整合揭示致命性3型髓母细胞瘤内依赖脂质的异质性
Flavia Bernardi,Jacob Torrejon,Irene Basili et al.
Flavia Bernardi et al.
Medulloblastoma, the most common malignant brain tumor of childhood, exhibits significant biological complexity that demands deeper exploration. Here, we present a large multiomics dataset integrating data from 384 primary medulloblastoma p...
A context-augmented large language model for accurate precision oncology medicine recommendations [0.03%]
一种上下文增强的大语言模型，用于精确的肿瘤学医学推荐
Hyeji Jun,Yutaro Tanaka,Shreya Johri et al.
Hyeji Jun et al.
The rapid expansion of molecularly informed therapies in oncology, coupled with evolving regulatory food and drug administration (FDA) approvals, poses a challenge for oncologists seeking to integrate precision oncology medicine into patien...
Single-cell integration and multi-modal profiling reveals phenotypes and spatial organization of neutrophils in colorectal cancer [0.03%]
单细胞整合和多模态谱型分析揭示结直肠癌中中性粒细胞的表型及空间分布特征
Valentin Marteau,Niloofar Nemati,Kristina Handler et al.
Valentin Marteau et al.
The immune composition of the tumor microenvironment has a major impact on the therapy response in patients with colorectal cancer. Here, we built an atlas with 4.27 million single cells from 1,670 patient samples and complemented it with s...
Characterization of a pathogenic subpopulation of human glioma associated macrophages linked to glioma progression [0.03%]
人胶质瘤相关巨噬细胞致病亚群的特征化与胶质瘤进展的关系
Kenny Kwok Hei Yu,Zaki Abou-Mrad,Kristof Törkenczy et al.
Kenny Kwok Hei Yu et al.
Primary de novo high grade gliomas, such as glioblastoma and lower grade gliomas both converge on a common aggressive phenotype, and the basis for this progression is unknown. Glioma associated macrophages (GAM) have been strongly implicate...
The ADAPT learning cancer treatment system: ARPA-H's initiative to revolutionize cancer therapy [0.03%]
ADAPT癌症治疗系统：ARPA-H发起的革命性癌症疗法倡议
Andrea H Bild,Michelle C Sangar,Jasmine A McQuerry et al.
Andrea H Bild et al.
ADAPT is a nationwide initiative to transform cancer care by detecting and responding to tumor evolution in real time. Integrating multimodal data, interpretable AI, and an evolutionary clinical trial platform, ADAPT predicts emerging resis...
Integrative proteogenomic analysis provides molecular insights and clinical significance in gallbladder cancer [0.03%]
整合蛋白质组分析为胆囊癌的分子机制和临床意义提供新的见解
Zile Fu,Yuanli Song,Fen Liu et al.
Zile Fu et al.
Gallbladder cancer (GBC) is a highly aggressive malignancy with dismal outcomes. To dissect its molecular characteristics and identify potential therapeutic avenues, we performed proteogenomic characterization of 195 tumors and 135 adjacent...
Framework for cancer evolution profiling and interception in colorectal cancer: ASCEND-CRC program [0.03%]
结直肠癌进化分析和阻断的框架：ASCEND-CRC项目
Salvador Alonso,Kanwal Raghav,Van K Morris et al.
Salvador Alonso et al.
Cancer evolution is a complex and dynamic process, yet most treatment strategies remain static. Infrequent tumor sampling has limited our ability to counteract the transient adaptive states that precede resistance. To address this gap, ARPA...