CCL3 is produced by aged neutrophils across cancers and promotes tumor growth [0.03%]
老年中性粒细胞产生的CCL3促进多种癌症的发生发展
Evangelia Bolli,Pratyaksha Wirapati,Mehdi Hicham et al.
Evangelia Bolli et al.
Tumor-associated neutrophils (TANs) are abundant across cancers, yet their phenotypic diversity and functional states remain poorly defined. Here, we introduce a cell-type probability classifier that recovers low-transcript neutrophils from...
Turn CAR T against TAMs [0.03%]
让CAR-T对抗TAMs
Alberto Mantovani,Cecilia Garlanda
Alberto Mantovani
The diversity of tumor-associated macrophages presents a major challenge to the clinical translation of myeloid cell-targeting strategies. In this issue of Cancer Cell, Yagel et al. and Mateus-Tique et al. demonstrate that IL-12 armored CAR...
Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS [0.03%]
库普弗细胞衍生的TNF通过慢性线粒体功能障碍和ROS引发JNK介导的胆管细胞肿瘤发生
Detian Yuan,Shan Huang,Emanuel Berger et al.
Detian Yuan et al.
Published Erratum
Cancer cell. 2026 Jan 31:S1535-6108(26)00052-8. DOI:10.1016/j.ccell.2026.01.013 2026
p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors [0.03%]
p53是SMARCB1缺陷型恶性肾母细胞瘤蛋白稳态的调控主开关
Alessandro Carugo,Rosalba Minelli,Luigi Sapio et al.
Alessandro Carugo et al.
Published Erratum
Cancer cell. 2026 Jan 31:S1535-6108(26)00057-7. DOI:10.1016/j.ccell.2026.01.018 2026
Jakob M Riedl,Hiroyuki Matsubara,Reid McNeil et al.
Jakob M Riedl et al.
Alterations in KRAS, NRAS, and HRAS occur in roughly 20% of patients with cancer, making RAS one of the most intensively studied oncogenic targets. The discovery of mutant-selective KRASG12C inhibitors has provided a proof-of-concept for RA...
Lymph node colonization induces tissue remodeling via immunosuppressive fibroblast-myeloid cell niches supporting metastatic tolerance [0.03%]
淋巴结定植通过免疫抑制成纤维细胞-髓系细胞生态位诱导组织重塑，以支持转移容许性
Maximilian Haist,Marc-A Baertsch,Nathan E Reticker-Flynn et al.
Maximilian Haist et al.
Lymph node (LN) colonization in cancer is linked to poor prognosis. Evidence suggests that LN colonization induces systemic immunosuppression, facilitating distant metastasis. We investigated LN-mediated immunosuppression in patients with h...
Justin Jee,Travis Zack
Justin Jee
In this issue of Cancer Cell, Jun et al. developed a retrieval-augmented large language model linked to an academia-led molecular knowledge database, demonstrating how AI may deliver cancer treatment information without hallucination. It mu...
IFNγ-dependent metabolic reprogramming restrains an immature, pro-metastatic lymphatic state in melanoma [0.03%]
干扰素γ依赖的代谢重编限制了黑色素瘤中一种促进转移的不成熟淋巴状态
Triantafyllia Karakousi,Vanessa Cristaldi,Maria Luiza Lopes de Oliveira et al.
Triantafyllia Karakousi et al.
Lymphatic vessels activate anti-tumor immune surveillance and support metastasis. Whether there are distinct lymphatic phenotypes that govern immunity and metastasis remains unclear. Here we reveal that cytotoxic immunity normalizes lymphat...
IGSF11-VISTA is a critical and targetable immune checkpoint axis in diffuse midline glioma [0.03%]
IGSF11-VISTA是弥漫性中线胶质瘤中的关键靶点免疫检查点轴
Raphaël Collot,Cristian Ruiz-Moreno,Celina Honhoff et al.
Raphaël Collot et al.
Diffuse midline glioma (DMG) is an aggressive pediatric brain tumor with no curative treatment, and lacks a comprehensive understanding of immune-tumor cell interactions within their spatial context. Our multi-omics approach, integrating si...
Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvironment and control metastatic cancer growth [0.03%]
装甲巨噬细胞靶向的CAR-T细胞可重置和重新编程肿瘤微环境并控制转移性癌症生长
Jaime Mateus-Tique,Ashwitha Lakshmi,Bhavya Singh et al.
Jaime Mateus-Tique et al.
Tumor-associated macrophages (TAMs), which commonly express FOLR2 or TREM2, are enriched in solid tumors and keep the tumor microenvironment (TME) immunosuppressed. Here, we introduce IL-12-expressing CAR-T cells targeting FOLR2 or TREM2 to...