Tumor-immune-neural circuit disrupts energy homeostasis in cancer cachexia [0.03%]
肿瘤免疫神经回路破坏癌症恶病质的能量平衡
Xiuhui Shi,Alex X Arreola,Zhijun Zhou et al.
Xiuhui Shi et al.
Cancer-induced cachexia and anorexia are debilitating complications across many cancers, yet effective treatments remain limited due to a poor understanding of the underlying mechanisms. Here, we identify an uncharacterized tumor-immune-neu...
Mehmet Kemal Samur,Nikhil C Munshi
Mehmet Kemal Samur
In this issue of Cancer Cell, Rade et al. report a longitudinal single-cell atlas of multiple myeloma patients receiving BCMA-directed chimeric antigen receptor (CAR) T cell therapy (ide-cel or cilta-cel) and identifiy features linked to lo...
Lipid oxidation reprogramming in cancer-associated fibroblasts enhances CD8+ T cell cytotoxicity and therapeutic response [0.03%]
癌相关成纤维细胞的脂质氧化重新编程增强CD8+t细胞的细胞毒性和治疗反应
Zikun Ma,Yuzhao Wang,Weikai Wang et al.
Zikun Ma et al.
Cancer-associated fibroblasts (CAFs) are major stromal components of the tumor microenvironment, yet how their metabolic states shift during therapy and influence anti-tumor immunity remains unclear. By integrating clinical cancer samples, ...
Zheng Jin,Haixia Long,Bo Zhu
Zheng Jin
In this issue of Cancer Cell, Bolli et al. leverage a newly developed neutrophil analysis framework to identify CCL3 as a conserved marker for tumor-associated neutrophils (TANs) across human and murine cancers. Using complementary genetic ...
Chemotherapy triggers immune evasion by fostering LEPR+ Kupffer cell differentiation in liver metastases [0.03%]
化疗通过促进肝脏转移灶中LEPR+枯否细胞分化触发免疫逃避
Xuege Wang,Qiang Pan,Yaqi Li et al.
Xuege Wang et al.
Conventional chemotherapy achieves clinical efficacy not only through its cytotoxic effects but also by reactivating immune surveillance. However, whether chemotherapy can inversely suppress antitumor immunity remains largely unexplored. He...
Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth [0.03%]
BNIP3L的表达受到缺氧条件下p53诱导，并发现其敲低促进肿瘤生长
Peiwen Fei,Wenge Wang,Seok-Hyun Kim et al.
Peiwen Fei et al.
Ubiquitin control of cytosolic DNA sets immune responses to DNA damage [0.03%]
泛素对胞质DNA的调控设定针对DNA损伤的免疫应答
Samuel F Bakhoum,Ashley M Laughney
Samuel F Bakhoum
In this issue of Cancer Cell, Li et al. uncover a novel SPOP-USP7-TREX1 axis that controls cytosolic DNA clearance after DNA damage, thereby gating tumor-cell-intrinsic cyclic GMP-AMP synthase (cGAS)-STING activation and response to radioim...
Enhancing therapeutic outcomes with artificial intelligence for HR-positive, HER2-negative metastatic breast cancer [0.03%]
人工智能在HR阳性、HER2阴性转移性乳腺癌治疗中的应用以增强疗效
Juan Luis Gomez Marti,Elena Michaels,Azadeh Nasrazadani et al.
Juan Luis Gomez Marti et al.
Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) are an integral first-line treatment for hormone receptor-positive metastatic breast cancer, though resistance eventually develops. In this issue of Cancer Cell, Fan et al. report results fro...
Reliable detection of Host-Microbe Signatures in cancer using PRISM [0.03%]
基于PRISM的癌症相关宿主微生物标志物的识别方法
Bassel Ghaddar,Martin J Blaser,Subhajyoti De
Bassel Ghaddar
Recent controversy in the cancer microbiome field highlights the need for more reliable microbial detection from human genomic data. Here, we develop PRISM, an efficient computational framework for precise microorganism identification and d...
Male-biased Yap1-Cd276/B7-H3 axis for immune evasion in medulloblastoma [0.03%]
小脑瘤中偏向男性的Yap1-Cd276 / B7-H3轴免疫逃逸路径
Nourhan Abdelfattah,Sivaraman Natarajan,Han Nhat Tran et al.
Nourhan Abdelfattah et al.
Molecular mechanisms underlying sex-specific differences in cancer incidence and therapy responses are under intense investigation. Here, we report sex-biased functions of Yap1 in multiple cancer types in human and mouse. Through integrated...