Tumor-restraining fibroblasts emerge after chemotherapy specifically in responders [0.03%]
化疗后仅在有效患者体内出现的肿瘤抑制成纤维细胞
Krishnan K Mahadevan,Raghu Kalluri
Krishnan K Mahadevan
In this issue of Cancer Cell, Ma et al. identify a neoadjuvant chemotherapy-induced population of PTGER3+ cancer-associated fibroblasts (CAFs) in patients with bladder cancer.1 These CAFs undergo lipid oxidation reprogramming and enhance CD...
Felix Clemens Richter,Joel Xu En Wong,Andreas Bergthaler
Felix Clemens Richter
Cancer-associated cachexia is a complex metabolic syndrome leading to sustained body weight loss and tissue wasting. In this issue of Cancer Cell, Shi et al. identify a novel GDF15-driven tumor-immune-brain crosstalk, resulting in altered s...
Xiaoqi Sun,Matthew D Park,Miriam Merad et al.
Xiaoqi Sun et al.
Tumor-associated macrophages (TAM) are among the most abundant immune cells in tumors and exhibit striking functional plasticity, enabling them to either promote tumor progression or mediate malignant cell elimination. This paradox arises f...
Candida albicans synergizes with Fusobacteriumnucleatum in colorectal cancer progression via the Flo9-RadD interaction [0.03%]
白色念珠菌通过Flo9-RadD相互作用与福氏耐危厌氧菌协同促进结直肠癌进展
Jialu Li,Chenyi Zhang,Xinhua Huang et al.
Jialu Li et al.
Fusobacterium nucleatum tumor infiltration is a hallmark of colorectal cancer (CRC) progression. However, whether and how other microbes influence F. nucleatum in CRC remains unclear. Here, we discover that the commensal fungus Candida albi...
Overcoming functional and translational challenges of cellular immunotherapies for solid tumors [0.03%]
细胞免疫治疗应对实体肿瘤的功能性和转化性挑战
Yi-Ching Chen,Kok-Siong Chen,Bruce L Levine et al.
Yi-Ching Chen et al.
In recent years, immunotherapy has revolutionized the landscape of cancer treatment, offering promising avenues for patients with otherwise limited outcomes. Among the most promising modalities are cell-based therapies, including autologous...
Nathan Dangle,Andy J Minn
Nathan Dangle
Lymphatic vessels assume two-faced roles in cancer, functioning as facilitators of both immune surveillance and metastasis. In this issue of Cancer Cell, Karakousi et al. establish IFNγ as a key phenotypic and metabolic switch in tumor-ass...
Gianmarco Piccinno,Robin Mjelle,Nicola Segata
Gianmarco Piccinno
Detecting the presence of microbial organisms within the tumor microenvironment may have biomedical relevance but presents serious technical challenges. In this issue of Cancer Cell, Ghaddar et al. develop a computational framework for the ...
Joren Brunekreef,Jonas Teuwen
Joren Brunekreef
In this issue of Cancer Cell, Zhou et al. present KEEP, a vision-language foundation model that incorporates hierarchical disease knowledge into pre-training via a structured disease graph. The knowledge-guided learning shapes semantic repr...
Dissecting genetic and immune drivers of heterogeneous responses to neoadjuvant immunochemotherapy in gastric cancer [0.03%]
胃癌新辅助免疫化疗异质性反应的遗传和免疫驱动因素解析
Qi Zhao,Runjie Huang,Chaoye Wang et al.
Qi Zhao et al.
Although neoadjuvant immunochemotherapy (nICT) improves gastric cancer (GC) outcomes, resistance remains a challenge, highlighting the need for better patient selection and strategies to overcome resistance. Here, we analyze 110 patients wi...
Knowledge-enhanced pretraining for vision-language pathology foundation model on cancer diagnosis [0.03%]
知识增强的视觉-语言病理基础模型癌症诊断预训练
Xiao Zhou,Luoyi Sun,Dexuan He et al.
Xiao Zhou et al.
Vision-language foundation models have shown great promise in computational pathology but remain primarily data-driven, lacking explicit integration of medical knowledge. We introduce KnowledgE-Enhanced Pathology (KEEP), a foundation model ...