Immunometabolic gatekeeping: How tissue metabolism conditions tumor immunity [0.03%]
免疫代谢控制：组织代谢如何决定肿瘤免疫反应
Naomi Iris van den Berg,Matouš Elphick,Kevin Mulder et al.
Naomi Iris van den Berg et al.
Why the link between immune infiltration and tumor control varies so strongly across tissues remains unresolved. We propose the "immunometabolic gatekeeping" framework, whereby tissue-intrinsic metabolic activity and waste-handling capacity...
Myofibroblast programming blocks differentiation of TLS-organizing fibroblastic reticular cells in pancreatic cancer [0.03%]
胰腺癌中肌纤维母细胞编程阻止TLS组织原代网状成纤维细胞分化
Elijah Kirschstein,Olivia Harder,Jordan Krull et al.
Elijah Kirschstein et al.
Pancreatic ductal adenocarcinoma (PDAC) is strongly resistant to immunotherapy. However, recent evidence shows that some PDAC tumors contain tertiary lymphoid structures (TLSs) associated with improved survival. Why TLS forms in some tumors...
Lior Lobel
Lior Lobel
In this issue of Cancer Cell, Li et al. show that Candida albicans and Fusobacterium nucleatum form a cross-kingdom interaction through Flo9-RadD binding that accelerates colorectal cancer (CRC) progression. Disrupting this interaction with...
Radiotherapy synergizes with an inducible AAV-based immunotherapy platform to program local and systemic antitumor immunity [0.03%]
放射治疗与可诱导的AAV免疫治疗平台协同作用编程局部和全身抗肿瘤免疫反应
Sonia Marco,Myriam Fernández,Beatriz Honorato et al.
Sonia Marco et al.
Radiotherapy (RT) can prime the immune system against cancer but often fails to generate effective antitumor responses due to concomitant induction of immunosuppressive factors. To overcome this limitation, we built upon the observation tha...
Stefan M Pfister,Lena M Kutscher
Stefan M Pfister
In this issue of Cancer Cell, Gudenas et al. reveal that Group 3 medulloblastoma, pineoblastoma, and retinoblastoma converge on a shared tumor-associated photoreceptor signature rooted in transient developmental progenitors. This work refra...
Robert Greenhalgh,Samuel W Brady,Wentao Yang et al.
Robert Greenhalgh et al.
Structural variants (SVs) account for over 60% of pediatric cancer driver variants. Pan-cancer analyses on 1,616 pediatric and 2,203 adult whole genomes show that pediatric SV burden varies ∼100-fold across cancer types, is reduced 6- to 1...
Toward a consensus on the tumor microbiota: Evidence, standards, and interpretation [0.03%]
迈向肿瘤微生物组共识：证据、标准和解读
Tingting Duan,Aviel Rosenbaum,Vidhi Chandra et al.
Tingting Duan et al.
Tumors across diverse organs harbor microbial communities that can shape cancer biology and therapeutic responses, yet the field remains polarized by technical and interpretive challenges. In this commentary, we synthesize functional and me...
HS-20093, a B7-H3-targeted antibody-drug conjugate in lung cancer: Results from the ARTEMIS-001 phase 1a/b trial [0.03%]
靶向B7-H3抗体药物偶联物HS-20093治疗肺癌ⅠA/ⅠB期临床研究ARTEMIS-001的结果
Jianchun Duan,Yuping Sun,Qiming Wang et al.
Jianchun Duan et al.
This phase 1a/b study (NCT05276609) evaluated the safety, pharmacokinetics, and efficacy of B7-H3-targeted antibody-drug conjugate HS-20093 (GSK5764227) in 306 patients with previously treated advanced solid tumors. In phase 1a, 12.0 mg/kg ...
Vascular STING activation facilitates NK cell anti-tumor immunity in small cell lung cancer [0.03%]
小细胞肺癌中血管STING活化促进NK细胞抗肿瘤免疫反应
Marco Campisi,Tatsuya Osaki,Ian Dryg et al.
Marco Campisi et al.
Small cell lung cancer (SCLC) typically displays a "cold" tumor microenvironment with a paucity of immune infiltrate. Neuroendocrine SCLC cells also profoundly repress MHC-I expression, rendering them vulnerable to NK cell-mediated cytotoxi...
A tumor-associated photoreceptor signature unifies distinct central nervous system malignancies [0.03%]
与肿瘤相关的视网膜受体谱系统一了不同的中枢神经系统恶性肿瘤
Brian L Gudenas,Shiekh Tanveer Ahmad,Bernhard Englinger et al.
Brian L Gudenas et al.
Pineoblastoma is a clinically aggressive childhood brain tumor composed of distinct molecular subgroups with divergent driver genes, demographics, and clinical outcomes. To identify developmental origins and mechanisms governing disease pat...