Weipeng Mo,Wange Lu,Nu Zhang
Weipeng Mo
In a recent Nature article, Koeber et al. engineer synthetic super-enhancers from glioblastoma-specific regulatory circuitry to act as precise gene switches. Combined with viral delivery of cytotoxic and immune-stimulating payloads, this ap...
Concurrent genetic and non-genetic resistance mechanisms to KRAS inhibition in colorectal cancer [0.03%]
结直肠癌并发的遗传和非遗传性抗KRAS抑制机制
Salvador Alonso,Kevan Chu,Elizabeth Granowsky et al.
Salvador Alonso et al.
KRAS is mutationally activated in 45%-50% of colorectal cancer (CRC) cases, and while KRAS-targeted therapies have shown clinical promise, drug resistance limits their efficacy. To explore the mechanisms underlying KRAS inhibitor resistance...
Krijn K Dijkstra,Roberto Vendramin,Despoina Karagianni et al.
Krijn K Dijkstra et al.
Published Erratum
Cancer cell. 2026 May 18:S1535-6108(26)00224-2. DOI:10.1016/j.ccell.2026.05.002 2026
Karam Khaddour,Patrick A Ott
Karam Khaddour
Personalized cancer neoantigen vaccines (PCV) represent an individualized form of immunotherapy. Neoantigens encoded by individual tumor mutations offer precise targets for robust, tumor-specific immunity. Next-generation sequencing and adv...
Dendritic cell redundancy enables priming of anti-tumor CD4+ T cells in pancreatic cancer [0.03%]
树突状细胞冗余可使胰腺癌中抗肿瘤CD4+t细胞活化诱导
Courtney T S Kureshi,Michael J Walsh,Rakeeb Kureshi et al.
Courtney T S Kureshi et al.
Pancreatic ductal adenocarcinoma (PDAC) is resistant to current immunotherapies and lacks effective anti-tumor CD8+ T cells, which is potentially due to insufficient cross-presentation by cDC1s. Here, we combine a STING agonist with anti-CT...
Cancer stem cells orchestrate immune evasion through extracellular vesicle-mediated non-canonical signaling pathways [0.03%]
癌细胞通过外泌体介导的非经典信号通路调控免疫逃逸
Guangjian Fan,Juan Jin,Jie Wang et al.
Guangjian Fan et al.
Tumor cells evade anti-tumor immunity by reprogramming tumor microenvironment (TME). Using multiplexed single-cell proteomics to analyze 50 TME-associated proteins across treatment-naive triple-negative breast cancer (TNBC) specimens, we di...
Whole-genome doubling drives immune evasion by silencing antigen presentation [0.03%]
全基因组加倍通过抑制抗原呈递来逃避免疫攻击
Pierre Foidart,Zheqi Li,Xinran Cai et al.
Pierre Foidart et al.
Whole-genome doubling (WGD) is a common yet poorly understood event associated with poor clinical outcomes. Here, we characterize mechanisms by which WGD drives tumor evolution, utilizing mouse mammary tumor models of WGD established throug...
Minh Truong Do,Ferdinandos Skoulidis
Minh Truong Do
Despite progress in elucidating the molecular landscape and actionable vulnerabilities of cholangiocarcinoma, clinical outcomes for patients with advanced disease remain dismal. In this issue of Cancer Cell, Entrialgo-Cadierno et al. raise ...
An Hendrix,Olivier De Wever
An Hendrix
Cancer stem cells (CSCs) shape immunosuppressive tumor microenvironments through diverse mechanisms. In this issue of Cancer Cell, Fan et al. demonstrate that CSC-derived extracellular vesicles promote regulatory T cell expansion and facili...
Nicole Cruz-Reyes,Derek C Radisky
Nicole Cruz-Reyes
In this issue of Cancer Cell, Hayward et al. show that fibrotic tissue tension creates a mechanically organized mutagenic niche. A stiff stroma activates epithelial STAT3, recruits macrophages, and drives NOX-dependent lipid peroxidation, g...