Eradicating micrometastases with immune checkpoint blockade: Strike while the iron is hot [0.03%]
趁热打铁：利用免疫检点阻断疗法消灭微转移病灶
Yelena Y Janjigian,Jedd D Wolchok,Charlotte E Ariyan
Yelena Y Janjigian
Immune checkpoint blockade (ICB) is transforming treatment for many cancers. While ICB alone initially demonstrated efficacy in patients with metastatic melanoma, it has expanded to other types and to earlier-stage cancers. We describe ICB ...
Ming O Li,Natalie Wolf,David H Raulet et al.
Ming O Li et al.
The tumor immune microenvironment (TIME) is a complex ecosystem that contains adaptive and innate immune cells that have tumor-promoting and anti-tumor effects. There is still much to learn about the diversity, plasticity, and functions of ...
Tim-4+ cavity-resident macrophages impair anti-tumor CD8+ T cell immunity [0.03%]
Tim-4+cavity-resident巨噬细胞削弱抗肿瘤CD8+t细胞免疫
Andrew Chow,Sara Schad,Michael D Green et al.
Andrew Chow et al.
Immune checkpoint blockade (ICB) has been a remarkable clinical advance for cancer; however, the majority of patients do not respond to ICB therapy. We show that metastatic disease in the pleural and peritoneal cavities is associated with p...
Claire E McCarthy,Nastaran Zahir,Mariam Eljanne et al.
Claire E McCarthy et al.
Owing to clinical success of immune-checkpoint blockade, immunotherapy is becoming a cornerstone of modern oncology, and immuno-oncology is at the forefront of basic cancer research. This commentary outlines future opportunities for immuno-...
Single-cell lineage tracing of metastatic cancer reveals selection of hybrid EMT states [0.03%]
单细胞系谱追踪揭示了上皮间质转化的混合态在癌症转移中的选择作用
Kamen P Simeonov,China N Byrns,Megan L Clark et al.
Kamen P Simeonov et al.
The underpinnings of cancer metastasis remain poorly understood, in part due to a lack of tools for probing their emergence at high resolution. Here we present macsGESTALT, an inducible CRISPR-Cas9-based lineage recorder with highly efficie...
Macrophage-tumor cell intertwine drives the transition into a mesenchymal-like cellular state of glioblastoma [0.03%]
巨噬细胞肿瘤细胞相互作用驱动胶质母细胞瘤向类似间充质的细胞状态转变
Zhihong Chen,Dolores Hambardzumyan
Zhihong Chen
Macrophages are the major non-neoplastic infiltrates in the glioblastoma microenvironment. In this issue of Cancer Cell, Hara et al. (2021) demonstrate that macrophages induce a transition of glioblastoma cells into the mesenchymal-like cel...
Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma [0.03%]
胶质母细胞瘤中癌细胞和免疫细胞间的相互作用导致上皮间叶转化现象的出现
Toshiro Hara,Rony Chanoch-Myers,Nathan D Mathewson et al.
Toshiro Hara et al.
The mesenchymal subtype of glioblastoma is thought to be determined by both cancer cell-intrinsic alterations and extrinsic cellular interactions, but remains poorly understood. Here, we dissect glioblastoma-to-microenvironment interactions...
N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation [0.03%]
mRNA上N6-甲基腺苷促进形成一种抑制髓系白血病分化的液-液相分离核小体
Yuanming Cheng,Wei Xie,Brian F Pickering et al.
Yuanming Cheng et al.
N6-Methyladenosine (m6A) on mRNAs mediates different biological processes and its dysregulation contributes to tumorigenesis. How m6A dictates its diverse molecular and cellular effects in leukemias remains unknown. We found that YTHDC1 is ...
Kathleen E Houlahan,Christina Curtis
Kathleen E Houlahan
In this issue of Cancer Cell, Bagaev et al. discover conserved relationships between immune and stroma activity that are prognostic and predictive of response to immunotherapy across cancer types. The authors develop a visualization tool, a...
The loss of RNA N6-adenosine methyltransferase Mettl14 in tumor-associated macrophages promotes CD8+ T cell dysfunction and tumor growth [0.03%]
肿瘤相关巨噬细胞中RNA N6-腺苷甲基转移酶Mettl14的丢失促进CD8+T细胞功能障碍和肿瘤生长
Lihui Dong,Chuanyuan Chen,Yawei Zhang et al.
Lihui Dong et al.
Tumor-associated macrophages (TAMs) can dampen the antitumor activity of T cells, yet the underlying mechanism remains incompletely understood. Here, we show that C1q+ TAMs are regulated by an RNA N6-methyladenosine (m6A) program and modula...