B cells disrupt tertiary lymphoid structure formation and suppress anti-tumor immunity [0.03%]
B细胞破坏三级淋巴组织结构的形成并抑制抗肿瘤免疫反应
Changhao Chen,Mingjie An,Hanhao Zheng et al.
Changhao Chen et al.
Tertiary lymphoid structures (TLSs) promote antigen-specific anti-tumor immunity, but the regulators of TLSs homeostasis in cancer remain unclear. Using single-cell RNA-sequencing and spatial transcriptomics, we identify an IGLL5+ B cell su...
Ubiquitination-directed cytosolic DNA degradation governs cGAS-STING-mediated immune response to DNA damage [0.03%]
泛素介导的细胞质DNA降解调控cGAS-STING介导的DNA损伤免疫应答
Lei Li,Qi Ye,Jinlu Ma et al.
Lei Li et al.
Activation of cGAS-STING signaling in cancer cells requires cytosolic DNA produced by intrinsic or treatment-induced DNA damage. However, clinical efforts to exploit this pathway to improve immunotherapy have yielded limited success, highli...
Antigen-specific profiling identifies T-bet+ melanoma-specific CD8+ T cells associated with response to neoadjuvant PD-1 blockade [0.03%]
抗原特异性谱分析鉴定出T-bet+黑色素瘤特异性CD8+T细胞与新辅助PD-1阻断反应相关性
Guanning Wang,Daniel Yoon,Ajeya Nandi et al.
Guanning Wang et al.
Despite widespread immune profiling in cancer immunotherapy, the antigen-specific responses that drive clinical outcomes remain poorly defined. In a prospective neoadjuvant trial (NCT04013854) of a single-dose anti-PD-1 (nivolumab) in stage...
Spatial omics at the forefront: emerging technologies, analytical innovations, and clinical applications [0.03%]
空间组学前沿：新兴技术、分析创新及临床应用
Yunhe Liu,Yibo Dai,Linghua Wang
Yunhe Liu
Spatial omics transforms our understanding of cancer by revealing how tumor cells and the microenvironment are organized, interact, and evolve within tissues. Here, we synthesize advances in spatial technologies that map tumor ecosystems wi...
Lorenzo Galluzzi,Oliver Kepp,Laurence Zitvogel et al.
Lorenzo Galluzzi et al.
Regulated cell death (RCD) shapes neoplastic transformation, tumor progression, and response to treatment. While apoptosis was long viewed as the only RCD variant, additional modalities, including necroptosis, pyroptosis, and ferroptosis, h...
Vito Amodio,Giorgio Patelli,Alberto Bardelli
Vito Amodio
In this issue of Cancer Cell, Zhang et al. show that dual KRAS-EGFR inhibition induces a reversible Paneth-like transition in colorectal cancer, sustaining mitogen-activated protein kinase (MAPK) reactivation through a SMAD1-FGFR3 axis. Thi...
Houtan Noushmehr
Houtan Noushmehr
DNA methylation patterns stratify tumors into distinct biological, prognostic, and therapeutic response features. In this issue of Cancer Cell, Sill et al. expand the Heidelberg CNS Tumor Methylation Classifier from 91 to 184 subclasses usi...
Epitranscriptomic control of cancer hallmarks: Functions, mechanisms, and therapeutics of RNA modifications [0.03%]
癌症标志的表转录组调控：RNA修饰的功能、机制和治疗作用
Xiaolan Deng,Dong Wu,Yingqi Zhao et al.
Xiaolan Deng et al.
The epitranscriptome, comprising over 170 distinct RNA modifications, represents a dynamic and multifaceted layer of gene regulation. These chemical marks such as N6-methyladenosine (m6A), 5-methylcytosine (m5C), and pseudouridine (Ψ) modu...
Caroline G Fahey,Anthony F Cordova,Patrick C Gedeon et al.
Caroline G Fahey et al.
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway bridges cytosolic DNA sensing with type I interferon activation in cancer. Despite promising preclinical results, generating clinically meaningful anti-tumor ...
Circulating tumor DNA as a biomarker in early phase clinical trials [0.03%]
循环肿瘤DNA在早期临床试验中的作用 Biomarker还是Surrogate？
Harold N Tan,Mitchell J Elliott,Ian M Silverman et al.
Harold N Tan et al.
The clinical development of novel cancer therapeutics is rapidly evolving with the integration of molecular biomarkers to advance precision medicine. Circulating tumor DNA (ctDNA) represents a versatile tool to detect targetable alterations...