William W Hay
William W Hay
Protein and amino acids derived from protein digestion in the gastrointestinal tract or from intravenous infusions are fundamental for normal metabolism, growth, and neurodevelopmental outcomes in the fetus and the preterm infant of the sam...
Nicholas D Embleton,Chris H P van den Akker,Mark Johnson
Nicholas D Embleton
Parenteral nutrition (PN) has been a key component of neonatal care for preterm infants since the 1980's and provides macronutrients for growth, along with electrolytes, minerals, vitamins and trace elements. In this article we consider com...
Catalina Bazacliu,Juan Carlos Roig,Josef Neu
Catalina Bazacliu
The GI tract-lung-brain axis refers to the communication network linking the gastrointestinal tract, central nervous system, and respiratory system. This axis is particularly significant in preterm neonates because their immune and nervous ...
Exclusive enteral nutrition in preterm infants: How early is too early? [0.03%]
早产儿早期使用全肠外营养的最佳时机是什么时候？
Ariel A Salas,Shalini Ojha
Ariel A Salas
With the growing availability of maternal and donor milk, neonatal feeding practices are undergoing significant transformation. Increasingly, neonatal units are prioritizing exclusive enteral nutrition soon after birth, a shift that represe...
Valeria Cortesi,Enrico Lopriore,Susanna Fustolo-Gunnink
Valeria Cortesi
In neonatal patients, bleeding is a multifactorial event in which several factors may play a pathogenic role. Among these, thrombocytopenia is often considered a risk factor for bleeding, although a causal relationship has never been demons...
Kimberly A Moyle
Kimberly A Moyle
Iron deficiency is a highly prevalent nutritional deficiency and the most common cause of anemia worldwide. Pregnant individuals are particularly susceptible due to increased demands to support expanding maternal blood volume and fetal grow...
Severe anemia predisposes very premature infants to transfusion-associated necrotizing enterocolitis [0.03%]
严重贫血使极早产婴儿易于发生输血相关的坏死性小肠结肠炎
Akhil Maheshwari
Akhil Maheshwari
Necrotizing enterocolitis (NEC) is a catastrophic inflammatory bowel necrosis of premature infants. The etiology is unknown, but 25-40 % of cases have a history of red blood cell (RBC) transfusions in the preceding 48 h. This association ha...
Patricia Davenport,Martha Sola-Visner
Patricia Davenport
Health and societal infant mortality burden of neonatal hemolytic disorders [0.03%]
新生儿溶血性疾病对健康和社会的婴儿死亡率负担
Ramesh Vidavalur,Vinod K Bhutani
Ramesh Vidavalur
Hemolytic disorders in neonates, once exceedingly common causes of infant mortality, have become increasingly rare and now largely non-fatal. Global advancements in neonatal care and deeper understanding of the mechanisms of neonatal hemoly...
Should granulocyte transfusion therapy for septic neutropenic neonates be resurrected? [0.03%]
粒细胞输注治疗是否应该用于有感染倾向的粒细胞缺乏的新生儿？
Shelley M Lawrence
Shelley M Lawrence
Nearly half a century ago, granulocyte transfusions were trialed in critically ill, septic, neutropenic neonates and showed improved survival when used concurrently with antimicrobials. Benefits were particularly noteworthy for Gram-negativ...