Neonatal skin: barrier, immunity and infection prevention in the NICU [0.03%]
新生儿皮肤：NICU 中的屏障、免疫和感染预防
Tobias Strunk,Jakob Steer,Andrew Currie
Tobias Strunk
The neonatal skin is central to early survival and immune development. Far from being a passive mechanical barrier, it integrates physical, chemical, and microbial defences that together protect the infant in the immediate postnatal period....
Juanita Lishman,Lars Naver,Helena Rabie
Juanita Lishman
Vertical transmission of HIV to newborns and infants during pregnancy, labour and delivery, and breastfeeding ranges from 15 % to 45 % without intervention. The most important risk factor for transmission is a high maternal viral load. Prev...
Charline Schmitt,Sybelle Goedicke-Fritz,Ingmar Fortmann et al.
Charline Schmitt et al.
Preterm infants, who represent around 10 % of births worldwide, are at markedly increased risk of infections due to their immunological immaturity and reduced maternal antibody transfer. Although international guidelines recommend immunizat...
"Gentle" cardio-respiratory management in congenital diaphragmatic hernia: Time for a precision-medicine approach? [0.03%]
先天性膈疝的"温和"心肺管理：精准医学时代来临？
Anna Foth,David Tingay,Florian Kipfmueller
Anna Foth
Congenital diaphragmatic hernia (CDH) remains one of the most challenging conditions to manage in neonatal intensive care, with outcomes determined by the complex interplay between pulmonary hypoplasia, pulmonary vascular remodeling, and ve...
Kia Hee Schultz Dungu,Emma Louise Malchau Carlsen,Olav Bjørn Petersen et al.
Kia Hee Schultz Dungu et al.
Neonatal herpes simplex virus (HSV) infection remains a life-threatening condition with high morbidity and mortality despite advances in diagnostics and therapy. Transmission occurs predominantly during delivery and the three main clinical ...
Nestor E Vain,Paolo Manzoni,Kee Thai Yeo
Nestor E Vain
Prevention of RSV lower respiratory tract infections (LRTI) in infants has been limited to general measures and palivizumab, a monoclonal antibody indicated for the highest risk groups. Recently developed RSV vaccines used during pregnancy ...
Central line-associated blood stream infections in newborns: From vulnerability to prevention [0.03%]
新生儿中央导管相关性血流感染：从易感性到可预防性
Varvara Dimopoulou,Kirsten Glaser,Eric Giannoni
Varvara Dimopoulou
Newborns, especially preterm infants, are vulnerable to invasive infections due to their developing immune system and frequent need for central venous catheters. Central line-associated bloodstream infections (CLABSI) are among the most com...
Yarlini Vipulanandan,Suresh Boppana,Karen B Fowler et al.
Yarlini Vipulanandan et al.
Congenital cytomegalovirus (CMV) infection is a large contributor to neurodevelopmental delay and non-genetic sensorineural hearing loss, which can often be delayed in onset. While a majority of CMV infections are asymptomatic in healthy ch...
Antibiotic stewardship in the neonatal intensive care unit and prevention of antimicrobial resistance [0.03%]
新生儿重症监护病房的抗生素管理和抗菌药物耐药性的预防
Ashraf Kharrat,Najla Tabbara,Prakesh S Shah
Ashraf Kharrat
Antimicrobial resistance is an evolving threat to infants admitted to the neonatal intensive care unit. Antibiotic-resistant organisms may colonize infants, cause infections, or contribute to nosocomial outbreaks, and are associated with in...
Probiotic supplementation - does it prevent or cause neonatal sepsis? [0.03%]
益生菌补充剂能预防新生儿败血症吗？还是会导致新生儿败血症？
Nicholas D Embleton,Chris H P van den Akker,Belal N Alshaikh
Nicholas D Embleton
Probiotic supplementation in preterm infants is one of the most extensively studied interventions in neonatal medicine, with over 50 randomised controlled trials. This paper examines the relationship between probiotic supplementation and la...